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Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC... Key PointsQuestionWhat is the long-term recurrence rate in patients with uncomplicated acute appendicitis treated with antibiotics? FindingsIn this 5-year observational follow-up of 257 patients initially treated with antibiotics for uncomplicated acute appendicitis, the cumulative incidence of recurrent appendicitis at 1, 2, 3, 4, and 5 years was 27.3% at 1 year, 34.0% at 2, 35.2% at 3, 37.1% at 4, and 39.1% at 5 years. MeaningLong-term follow up of patients with uncomplicated acute appendicitis suggests that initial treatment with antibiotics rather than surgery may be a feasible alternative. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.13201
pmid
30264120
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the long-term recurrence rate in patients with uncomplicated acute appendicitis treated with antibiotics? FindingsIn this 5-year observational follow-up of 257 patients initially treated with antibiotics for uncomplicated acute appendicitis, the cumulative incidence of recurrent appendicitis at 1, 2, 3, 4, and 5 years was 27.3% at 1 year, 34.0% at 2, 35.2% at 3, 37.1% at 4, and 39.1% at 5 years. MeaningLong-term follow up of patients with uncomplicated acute appendicitis suggests that initial treatment with antibiotics rather than surgery may be a feasible alternative.

Journal

JAMAAmerican Medical Association

Published: Sep 25, 2018

References