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Fish Oil Consumption Reduces Hypertriglyceridemia in Psoriatic Patients Receiving Etretinate Therapy

Fish Oil Consumption Reduces Hypertriglyceridemia in Psoriatic Patients Receiving Etretinate Therapy Abstract To the Editor.— Etretinate has been shown to be effective in severe types of psoriasis.1 Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in both normolipidemic and hyperlipidemic subjects.2 The effects of fish oil on serum lipids in 11 psoriatic patients with drug-induced hyperlipidemia from etretinate (aromatic retinoid) therapy were investigated (Table). These patients received 3 g of omega-3 fatty acids (1.8 g of eicosapentaenoic acid, EPA 20:5w3; 1.2 g of docosahexaenoic acid, DHA 22:6w3; Pharmavite, Los Angeles) and continued to consume their normal diet for four weeks. The fish oil supplementation led to a significant decrease in mean plasma triglyceride concentration from 3.31 ± 1.64 mmol/L (293 ± 145 mg/dL) (SD) to 2.32 ± 1.14 mmol/L (206 ± 101 mg/ dL) (-30%, P <.001), and a significant increase in both high-density lipoprotein cholesterol from 1.01 ± 0.28 References 1. Kaplan RP, Russell DH, Lowe NJ: Etretinate therapy for psoriasis: Clinical responses, remission times, epidermal DNA, and polyamine responses . J Am Acad Dermatol 1983;8:95-102.Crossref 2. Simopoulos AP: Summary of the conference on the health effects of polyunsaturated fatty acids in seafoods . J Nutr 1986; 116:2350-2354. 3. Marsden J: Hyperlipidaemia due to isotretinoin and etretinate: Possible mechanisms and consequences . Br J Dermatol 1986;114:401-407.Crossref 4. Marsden JR: Reduction of retinoid hyperlipidaemia with MaxEPA . Br J Dermatol 1987;116:450 5. Ziboh VA, Cohen KA, Ellis CN, et al: Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids . Arch Dermatol 1986;122:1277-1282.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Fish Oil Consumption Reduces Hypertriglyceridemia in Psoriatic Patients Receiving Etretinate Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670020009003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Etretinate has been shown to be effective in severe types of psoriasis.1 Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in both normolipidemic and hyperlipidemic subjects.2 The effects of fish oil on serum lipids in 11 psoriatic patients with drug-induced hyperlipidemia from etretinate (aromatic retinoid) therapy were investigated (Table). These patients received 3 g of omega-3 fatty acids (1.8 g of eicosapentaenoic acid, EPA 20:5w3; 1.2 g of docosahexaenoic acid, DHA 22:6w3; Pharmavite, Los Angeles) and continued to consume their normal diet for four weeks. The fish oil supplementation led to a significant decrease in mean plasma triglyceride concentration from 3.31 ± 1.64 mmol/L (293 ± 145 mg/dL) (SD) to 2.32 ± 1.14 mmol/L (206 ± 101 mg/ dL) (-30%, P <.001), and a significant increase in both high-density lipoprotein cholesterol from 1.01 ± 0.28 References 1. Kaplan RP, Russell DH, Lowe NJ: Etretinate therapy for psoriasis: Clinical responses, remission times, epidermal DNA, and polyamine responses . J Am Acad Dermatol 1983;8:95-102.Crossref 2. Simopoulos AP: Summary of the conference on the health effects of polyunsaturated fatty acids in seafoods . J Nutr 1986; 116:2350-2354. 3. Marsden J: Hyperlipidaemia due to isotretinoin and etretinate: Possible mechanisms and consequences . Br J Dermatol 1986;114:401-407.Crossref 4. Marsden JR: Reduction of retinoid hyperlipidaemia with MaxEPA . Br J Dermatol 1987;116:450 5. Ziboh VA, Cohen KA, Ellis CN, et al: Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids . Arch Dermatol 1986;122:1277-1282.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1988

References