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First Metastasis of Breast Cancer

First Metastasis of Breast Cancer Abstract Few will find fault with the recent statement of Burnet3 that "the understanding and control of cancer is the most urgent problem in medicine today." Yet it is discouraging to realize that over 50 years have elapsed since the first exciting experimental discovery that it was possible to transplant a mammary tumor from one animal to another. Although the patient with breast cancer is assured of receiving treatment which combines the cumulative experience of over half a century, both in surgery and in radiotherapy, nonetheless, in many instances the patient's survival is brief despite the best efforts of the most skilled surgeon. Ultimately the problem must be solved by the continual pooling of knowledge from both clinical and biological fields. As an organ prone to cyclic changes and to enlargement on physiological demand, the breast is endowed with a copious blood supply, derived from the subclavian and axillary vessels. References 1. Anderson, E.; Reed, S. C.; Huseby, R. A., and Oliver, C. P.: Possible Relationship Between Menopause and Age at Onset of Breast Cancer , Cancer 3:410-414, 1950.Crossref 2. Berg, J. W.: Significance of Axillary Node Levels in the Study of Breast Carcinoma , Cancer 8:776-778, 1955.Crossref 3. Burnet, M.: Cancer—a Biological Approach , Brit. M. J. 1:779-786, 1957.Crossref 4. Collins, V. P.: Breast Cancer: The Influence of Treatment That Fails to Cure , Cancer 9:1177-1181, 1956.Crossref 5. Ewing, J.: Neoplastic Diseases , Ed. 4, Philadelphia, W. B. Saunders Company, 1940. 6. Gray, J. H.: Relation of Lymphatic Vessels to the Spread of Cancer , Brit. J. Surg. 26:462-495, 1938.Crossref 7. Hadfield, G.: The Dormant Cancer Cell , Brit. M. J. 2:607-610, 1954.Crossref 8. Handley, W. S.: Cancer of the Breast and Its Operative Treatment , Ed. 2, London, G. Murray, 1922. 9. Hultborn, K. A.; Larsson, L. G., and Ragnhult, I.: The Lymph Drainage from the Breast to the Axillary and Parasternal Lymph Nodes, Studied with the Aid of Colloidal Au198 , Acta radiol. 43:52-64, 1955.Crossref 10. Kolodny, A.: Relation of the Bone Marrow to the Lymphatic System: Its Role in the Spreading of Carcinomatous Metastases Throughout the Skeleton , Arch. Surg. 11:690-707, 1925.Crossref 11. Moore, O. S., Jr., and Foote, F. W., Jr.: The Relatively Favorable Prognosis of Medullary Carcinoma of the Breast , Cancer 2:635-642, 1949.Crossref 12. Paget, S.: The Distribution of Secondary Growths in Cancer of the Breast , Lancet 1:571573, 1889. 13. Price, P. B.: Spread of Mammary Carcinoma , J. A. M. A. 159:1345-1347, 1955.Crossref 14. Rigby-Jones, P.: The Influence of Various Factors on Metastases in Carcinoma of the Breast , Brit. J. Cancer 7:431-437, 1953.Crossref 15. Saphir, O., and Amromin, G. D.: Obscure Axillary Lymph-Node Metastasis in Carcinoma of the Breast , Cancer 1:238-241, 1948.Crossref 16. Williams, I. G.: The Role of Radiotherapy and Surgery in the Treatment of Cancer of the Breast , Brit. J. Radiol. 30:505-515, 1957.Crossref 17. Willis, R. A.: The Spread of Tumours in the Human Body , Ed. 2, London, Butterworth & Co., Ltd., 1952. 18. Zeidman, I., and Buss, J. M.: Experimental Studies on Spread of Cancer in Lymphatic System: The Effectiveness of the Lymph Node as a Barrier to the Passage of Embolic Tumor Cells , Cancer Res. 14:403-405, 1954. 19. Zeidman, I.: Metastasis: A Review of Recent Advances , Cancer Res. 17:157-162, 1957. 20. Colles, A.: Treatise on Surgical Anatomy , Dublin, Gilbert & Hodges, 1811. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1959.04320040114025
Publisher site
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Abstract

Abstract Few will find fault with the recent statement of Burnet3 that "the understanding and control of cancer is the most urgent problem in medicine today." Yet it is discouraging to realize that over 50 years have elapsed since the first exciting experimental discovery that it was possible to transplant a mammary tumor from one animal to another. Although the patient with breast cancer is assured of receiving treatment which combines the cumulative experience of over half a century, both in surgery and in radiotherapy, nonetheless, in many instances the patient's survival is brief despite the best efforts of the most skilled surgeon. Ultimately the problem must be solved by the continual pooling of knowledge from both clinical and biological fields. As an organ prone to cyclic changes and to enlargement on physiological demand, the breast is endowed with a copious blood supply, derived from the subclavian and axillary vessels. References 1. Anderson, E.; Reed, S. C.; Huseby, R. A., and Oliver, C. P.: Possible Relationship Between Menopause and Age at Onset of Breast Cancer , Cancer 3:410-414, 1950.Crossref 2. Berg, J. W.: Significance of Axillary Node Levels in the Study of Breast Carcinoma , Cancer 8:776-778, 1955.Crossref 3. Burnet, M.: Cancer—a Biological Approach , Brit. M. J. 1:779-786, 1957.Crossref 4. Collins, V. P.: Breast Cancer: The Influence of Treatment That Fails to Cure , Cancer 9:1177-1181, 1956.Crossref 5. Ewing, J.: Neoplastic Diseases , Ed. 4, Philadelphia, W. B. Saunders Company, 1940. 6. Gray, J. H.: Relation of Lymphatic Vessels to the Spread of Cancer , Brit. J. Surg. 26:462-495, 1938.Crossref 7. Hadfield, G.: The Dormant Cancer Cell , Brit. M. J. 2:607-610, 1954.Crossref 8. Handley, W. S.: Cancer of the Breast and Its Operative Treatment , Ed. 2, London, G. Murray, 1922. 9. Hultborn, K. A.; Larsson, L. G., and Ragnhult, I.: The Lymph Drainage from the Breast to the Axillary and Parasternal Lymph Nodes, Studied with the Aid of Colloidal Au198 , Acta radiol. 43:52-64, 1955.Crossref 10. Kolodny, A.: Relation of the Bone Marrow to the Lymphatic System: Its Role in the Spreading of Carcinomatous Metastases Throughout the Skeleton , Arch. Surg. 11:690-707, 1925.Crossref 11. Moore, O. S., Jr., and Foote, F. W., Jr.: The Relatively Favorable Prognosis of Medullary Carcinoma of the Breast , Cancer 2:635-642, 1949.Crossref 12. Paget, S.: The Distribution of Secondary Growths in Cancer of the Breast , Lancet 1:571573, 1889. 13. Price, P. B.: Spread of Mammary Carcinoma , J. A. M. A. 159:1345-1347, 1955.Crossref 14. Rigby-Jones, P.: The Influence of Various Factors on Metastases in Carcinoma of the Breast , Brit. J. Cancer 7:431-437, 1953.Crossref 15. Saphir, O., and Amromin, G. D.: Obscure Axillary Lymph-Node Metastasis in Carcinoma of the Breast , Cancer 1:238-241, 1948.Crossref 16. Williams, I. G.: The Role of Radiotherapy and Surgery in the Treatment of Cancer of the Breast , Brit. J. Radiol. 30:505-515, 1957.Crossref 17. Willis, R. A.: The Spread of Tumours in the Human Body , Ed. 2, London, Butterworth & Co., Ltd., 1952. 18. Zeidman, I., and Buss, J. M.: Experimental Studies on Spread of Cancer in Lymphatic System: The Effectiveness of the Lymph Node as a Barrier to the Passage of Embolic Tumor Cells , Cancer Res. 14:403-405, 1954. 19. Zeidman, I.: Metastasis: A Review of Recent Advances , Cancer Res. 17:157-162, 1957. 20. Colles, A.: Treatise on Surgical Anatomy , Dublin, Gilbert & Hodges, 1811.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Apr 1, 1959

References