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First-Episode Schizophrenia and Diabetes Risk

First-Episode Schizophrenia and Diabetes Risk Letters 4,5 addictions including GD. Neuroimaging studies could shed Because long-term antipsychotic use increases the risk for light on the sensibility of such an approach and could poten- type 2 diabetes, this is a confounding factor in the association tially guide future treatment development for substance and of impaired glucose homeostasis and schizophrenia. Being behavioral addictions. able to remove this bias by analyzing individuals with first- In conclusion, we fully agree with van Holst et al that more episode schizophrenia allows observation of early alterations studies investigating reward processing in behavioral addic- in glucose homeostasis in this subgroup. This finding of tions are needed to further advance our understanding of abnormal glucose homeostasis at disease onset supports the shared and distinct neural mechanisms contributing to SUD concept that bioenergetic dysregulation driven by mitochon- and behavioral addictions. drial dysfunction may represent a common molecular mecha- nism that underpins both schizophrenia and type 2 diabetes, Arnt F. Schellekens, MD, PhD and explains, at least in part, their frequent co-occurrence. Maartje Luijten, PhD In summary, Pillinger and colleagues’ study creates an im- Guillaume Sescousse, PhD perative for new research to determine the molecular mecha- nism(s) defining the potentially overlapping relationship Author Affiliations: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

First-Episode Schizophrenia and Diabetes Risk

JAMA Psychiatry , Volume 74 (7) – Jul 24, 2017

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2017.0760
Publisher site
See Article on Publisher Site

Abstract

Letters 4,5 addictions including GD. Neuroimaging studies could shed Because long-term antipsychotic use increases the risk for light on the sensibility of such an approach and could poten- type 2 diabetes, this is a confounding factor in the association tially guide future treatment development for substance and of impaired glucose homeostasis and schizophrenia. Being behavioral addictions. able to remove this bias by analyzing individuals with first- In conclusion, we fully agree with van Holst et al that more episode schizophrenia allows observation of early alterations studies investigating reward processing in behavioral addic- in glucose homeostasis in this subgroup. This finding of tions are needed to further advance our understanding of abnormal glucose homeostasis at disease onset supports the shared and distinct neural mechanisms contributing to SUD concept that bioenergetic dysregulation driven by mitochon- and behavioral addictions. drial dysfunction may represent a common molecular mecha- nism that underpins both schizophrenia and type 2 diabetes, Arnt F. Schellekens, MD, PhD and explains, at least in part, their frequent co-occurrence. Maartje Luijten, PhD In summary, Pillinger and colleagues’ study creates an im- Guillaume Sescousse, PhD perative for new research to determine the molecular mecha- nism(s) defining the potentially overlapping relationship Author Affiliations:

Journal

JAMA PsychiatryAmerican Medical Association

Published: Jul 24, 2017

References