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Fingerprint Dystrophy of the Cornea: A Histologic Study

Fingerprint Dystrophy of the Cornea: A Histologic Study Abstract A case of fingerprint corneal dystrophy with epithelial cysts has been studied histologically, using ultrathin sections for light and electron microscopy. Fingerprint lines that are ensheathed in normal basement membrane consist of a fibrillogranular protein apparently a product of the corneal epithelium. They are continuous with a subepithelial seam of similar, friable material thus accounting for the ready dehiscence and recurrent breakdown of the epithelium. Moribund cells stimulate fusion of epithelial cells to form multinucleate giant cells. These seclude degenerating cells that thus sequestered are taken by centripetal cell movement toward the tear film where they are discharged. The histologic evidence suggests that fingerprint dystrophy, the microcystic dystrophy of Cogan, and the recurrent erosion syndrome are closely related disorders. References 1. Bron AJ, Brown NA: Some superficial corneal disorders . Trans Ophthalmol Soc UK 91:13-29, 1971. 2. Cogan DG, et al: Microcystic dystrophy of the corneal epithelium . Trans Am Ophthalmol Soc 62:213-225, 1964. 3. Guerry D: Observations on Cogan's microcystic dystrophy of the corneal epithelium . Trans Am Ophthalmol Soc 63:320-334, 1965. 4. Kaufman HE: Epithelial erosion syndrome: Metaherpetic keratitis . Am J Ophthalmol 57:983-987, 1964. 5. Tripathi RC, Bron AJ: Ultrastructural study of nontraumatic recurrent corneal erosion . Br J Ophthalmol 56:73-85, 1972.Crossref 6. Franceschetti A, et al: Clinical and social aspects of heredity in ophthalmology . Acta XVI Concilium Ophthalmologicum Britannia . London, British Medical Association, 1951, vol 1, pp 157-299. 7. Trobe JD, Laibson PR: Dystrophic changes in the anterior cornea . Arch Ophthalmol 87:378-382, 1972.Crossref 8. De Voe AG: Certain abnormalities of Bowman's membrane with particular reference to fingerprint lines in the cornea . Tr Am Ophthalmol Soc 60:195-201, 1962. 9. Chandler PA: Recurrent erosions of the cornea . Am J Ophthalmol 28:355-363, 1945. 10. Kaufman HE, Clower JW: Irregularities of Bowman's membrane . Am J Ophthalmol 61:227-230, 1966. 11. Guerry D: Fingerprint-like lines in the cornea . Am J Ophthalmol 33:724-727, 1950. 12. Graves B: A bilateral chronic affection of the endothelial face of the cornea of elderly persons with an account of the technical and clinical principles of its slitlamp observation . Br J Ophthalmol 8:502-544, 1924.Crossref 13. Zander E, Weddell G: Reaction of corneal nerve fibres . Br J Ophthalmol 35:61-88, 1951.Crossref 14. Dark AJ: Formed elements in the human lens capsule . Br J Ophthalmol 45:298-306, 1961.Crossref 15. Bertelson TI, Drablos PA, Flood PR: The so-called senile exfoliation (pseudoexfoliation) of the anterior lens capsule . Acta Ophthalmol 42:1096-1113, 1964.Crossref 16. Ashton N, et al: Electron microscopic study of pseudoexfoliation of the lens capsule . Invest Ophthalmol 4:141-161, 1965. 17. Dark AJ, Streeten BW, Jones D: Accumulation of fibrillar protein in the aging human lens capsule: With special reference to the pathogenesis of pseudoexfoliative disease of the lens . Arch Ophthalmol 82:815-821, 1969.Crossref 18. Henkind P, Prose P: Anterior polar cataract: Electron microscopic evidence of collagen . Am J Ophthalmol 63:768-771, 1967. 19. Goldsmith M: The anatomy of cell death . J Cell Biol 31:41, 1966. 20. Klion FM, Schaffner F: The ultrastructure of acidophilic councilman-like bodies in the liver . Am J Pathol 48:758-767, 1966. 21. Wilgram GF, et al: Sunburn effect on keratinosomes . Arch Dermatol 101:505-519, 1970.Crossref 22. Kerr JFR, Wyllie AH, Currie AR: Aproptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics . Br J Cancer 26:239-255, 1972.Crossref 23. Kuwabara T, Ciccarelli EC: Meesmann's corneal dystrophy: A pathological study . Arch Ophthalmol 71:676-682, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Fingerprint Dystrophy of the Cornea: A Histologic Study

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1974.01010010497006
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Abstract

Abstract A case of fingerprint corneal dystrophy with epithelial cysts has been studied histologically, using ultrathin sections for light and electron microscopy. Fingerprint lines that are ensheathed in normal basement membrane consist of a fibrillogranular protein apparently a product of the corneal epithelium. They are continuous with a subepithelial seam of similar, friable material thus accounting for the ready dehiscence and recurrent breakdown of the epithelium. Moribund cells stimulate fusion of epithelial cells to form multinucleate giant cells. These seclude degenerating cells that thus sequestered are taken by centripetal cell movement toward the tear film where they are discharged. The histologic evidence suggests that fingerprint dystrophy, the microcystic dystrophy of Cogan, and the recurrent erosion syndrome are closely related disorders. References 1. Bron AJ, Brown NA: Some superficial corneal disorders . Trans Ophthalmol Soc UK 91:13-29, 1971. 2. Cogan DG, et al: Microcystic dystrophy of the corneal epithelium . Trans Am Ophthalmol Soc 62:213-225, 1964. 3. Guerry D: Observations on Cogan's microcystic dystrophy of the corneal epithelium . Trans Am Ophthalmol Soc 63:320-334, 1965. 4. Kaufman HE: Epithelial erosion syndrome: Metaherpetic keratitis . Am J Ophthalmol 57:983-987, 1964. 5. Tripathi RC, Bron AJ: Ultrastructural study of nontraumatic recurrent corneal erosion . Br J Ophthalmol 56:73-85, 1972.Crossref 6. Franceschetti A, et al: Clinical and social aspects of heredity in ophthalmology . Acta XVI Concilium Ophthalmologicum Britannia . London, British Medical Association, 1951, vol 1, pp 157-299. 7. Trobe JD, Laibson PR: Dystrophic changes in the anterior cornea . Arch Ophthalmol 87:378-382, 1972.Crossref 8. De Voe AG: Certain abnormalities of Bowman's membrane with particular reference to fingerprint lines in the cornea . Tr Am Ophthalmol Soc 60:195-201, 1962. 9. Chandler PA: Recurrent erosions of the cornea . Am J Ophthalmol 28:355-363, 1945. 10. Kaufman HE, Clower JW: Irregularities of Bowman's membrane . Am J Ophthalmol 61:227-230, 1966. 11. Guerry D: Fingerprint-like lines in the cornea . Am J Ophthalmol 33:724-727, 1950. 12. Graves B: A bilateral chronic affection of the endothelial face of the cornea of elderly persons with an account of the technical and clinical principles of its slitlamp observation . Br J Ophthalmol 8:502-544, 1924.Crossref 13. Zander E, Weddell G: Reaction of corneal nerve fibres . Br J Ophthalmol 35:61-88, 1951.Crossref 14. Dark AJ: Formed elements in the human lens capsule . Br J Ophthalmol 45:298-306, 1961.Crossref 15. Bertelson TI, Drablos PA, Flood PR: The so-called senile exfoliation (pseudoexfoliation) of the anterior lens capsule . Acta Ophthalmol 42:1096-1113, 1964.Crossref 16. Ashton N, et al: Electron microscopic study of pseudoexfoliation of the lens capsule . Invest Ophthalmol 4:141-161, 1965. 17. Dark AJ, Streeten BW, Jones D: Accumulation of fibrillar protein in the aging human lens capsule: With special reference to the pathogenesis of pseudoexfoliative disease of the lens . Arch Ophthalmol 82:815-821, 1969.Crossref 18. Henkind P, Prose P: Anterior polar cataract: Electron microscopic evidence of collagen . Am J Ophthalmol 63:768-771, 1967. 19. Goldsmith M: The anatomy of cell death . J Cell Biol 31:41, 1966. 20. Klion FM, Schaffner F: The ultrastructure of acidophilic councilman-like bodies in the liver . Am J Pathol 48:758-767, 1966. 21. Wilgram GF, et al: Sunburn effect on keratinosomes . Arch Dermatol 101:505-519, 1970.Crossref 22. Kerr JFR, Wyllie AH, Currie AR: Aproptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics . Br J Cancer 26:239-255, 1972.Crossref 23. Kuwabara T, Ciccarelli EC: Meesmann's corneal dystrophy: A pathological study . Arch Ophthalmol 71:676-682, 1964.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Dec 1, 1974

References

  • Some superficial corneal disorders
    Bron AJ, Brown NA
  • Microcystic dystrophy of the corneal epithelium
    Cogan DG, et al
  • Observations on Cogan's microcystic dystrophy of the corneal epithelium
    Guerry D
  • Epithelial erosion syndrome: Metaherpetic keratitis
    Kaufman HE
  • Ultrastructural study of nontraumatic recurrent corneal erosion
    Tripathi RC, Bron AJ
  • Acta XVI Concilium Ophthalmologicum Britannia
    Franceschetti A, et al
  • Dystrophic changes in the anterior cornea
    Trobe JD, Laibson PR
  • Certain abnormalities of Bowman's membrane with particular reference to fingerprint lines in the cornea
    De Voe AG
  • Recurrent erosions of the cornea
    Chandler PA
  • Irregularities of Bowman's membrane
    Kaufman HE, Clower JW
  • Fingerprint-like lines in the cornea
    Guerry D
  • A bilateral chronic affection of the endothelial face of the cornea of elderly persons with an account of the technical and clinical principles of its slitlamp observation
    Graves B
  • Reaction of corneal nerve fibres
    Zander E, Weddell G
  • Formed elements in the human lens capsule
    Dark AJ
  • The so-called senile exfoliation (pseudoexfoliation) of the anterior lens capsule
    Bertelson TI, Drablos PA, Flood PR
  • Electron microscopic study of pseudoexfoliation of the lens capsule
    Ashton N, et al
  • Accumulation of fibrillar protein in the aging human lens capsule: With special reference to the pathogenesis of pseudoexfoliative disease of the lens
    Dark AJ, Streeten BW, Jones D
  • Anterior polar cataract: Electron microscopic evidence of collagen
    Henkind P, Prose P
  • The anatomy of cell death
    Goldsmith M
  • The ultrastructure of acidophilic councilman-like bodies in the liver
    Klion FM, Schaffner F
  • Sunburn effect on keratinosomes
    Wilgram GF, et al
  • Aproptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics
    Kerr JFR, Wyllie AH, Currie AR
  • Meesmann's corneal dystrophy: A pathological study
    Kuwabara T, Ciccarelli EC