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Fibrous Hamartoma of Infancy: Eight Additional Cases and a Review of the Literature

Fibrous Hamartoma of Infancy: Eight Additional Cases and a Review of the Literature Abstract • Fibrous hamartoma of infancy is a benign but persistent soft-tissue tumor that appears during the first two years of life. Although the lesion is not distinctive clinically, histopathologic examination of affected tissue reveals the three characteristic elements: fibrous, adipose, and myxoid mesenchymal tissue. Sixty-seven patients with fibrous hamartoma of infancy have been described previously, few in the dermatologic literature. In this report, we describe eight additional patients and present a compilation of the clinical statistics of all 75 cases. (Arch Dermatol 1989;125:88-91) References 1. Reye RDK: A consideration of certain subdermal `fibromatous tumours' of infancy . J Pathol 1956;72:149-154.Crossref 2. Mayayo Artal E, Mestres Caldentey M, Baeta Capellera J, et al: Hamartoma fibroso de la infancia, tumor de peculiar presentación a nivel escrotal . An Esp Pediatr 1986;25:136-138. 3. Enziger FM: Fibrous hamartoma of infancy . Cancer 1965;18:241-248.Crossref 4. Stout AP: Juvenile fibromatoses . Cancer 1954;7:953-978.Crossref 5. Allen AC: The Skin: A Clinicopathologic Treatise . St Louis, CV Mosby Co, 1954, p 943. 6. Greco MA, Schinella RA, Vuletin JC: Fibrous hamartoma of infancy: An ultrastructural study . Hum Pathol 1984;15:717-723.Crossref 7. Mitchell ML, Di Sant'Agnese PA, Gerber JE: Fibrous hamartoma of infancy . Hum Pathol 1982;13:586-588.Crossref 8. King DF, Barr RJ, Hirose FM: Fibrous hamartoma of infancy . J Dermatol Surg Oncol 1979;5:482-483.Crossref 9. Gang DL: Case 3: Fibrous hamartoma of infancy . Pediatr Pathol 1984;2:339-344.Crossref 10. Robbins LB, Hoffman S, Kahn S: Fibrous hamartoma of infancy . Plast Reconstr Surg 1970;46:197-200.Crossref 11. Gupta JC, Salgia KM, Sharma HSD: Fibrous hamartoma of infancy: A case report . Indian J Med Sci 1966;20:507-508. 12. Shimada K, Oomori M, Kobayashi S, et al: A case of fibrous hamartoma of infancy and review of the Japanese literature . Gan No Rinsho 1986;32:293-298. 13. Maung R, Lindsay R, Trevener C, et al: Fibrous hamartoma of infancy . Hum Pathol 1987;18:652-653.Crossref 14. Albukerk J, Wexler H, Dana M, et al: A case of fibrous hamartoma of infancy . J Pediatr Surg 1979;14:80-82.Crossref 15. Baarsma EA: Juvenile fibrous hamartoma of the pharynx . J Laryngol Otol 1979;93:75-79.Crossref 16. Goldstein SA, Imbriglia JE: Fibrous hamartoma of the wrist in infancy . J Hand Surg 1986;11A:847-849.Crossref 17. Harris CJ, Das S, Vogt PJ: Fibrous hamartoma of infancy in the scrotum . J Urol 1982;127:781-782. 18. Mehregan AH: Superficial fibrous tumors in childhood . J Cutan Pathol 1981;8:321-334.Crossref 19. Baselga C, Lario A, López MJ, et al: Hamartoma fibroso de pared costal: A propósito de un caso . An Esp Pediatr 1984;20:130-134. 20. Rosenberg HS, Stenback WA, Spjut HJ: The fibromatoses of infancy and childhood , in Rosenberg HS, Bolande RP (eds): Perspectives in Pediatric Pathology . Chicago, Year Book Medical Publishers Inc, 1978, pp 269-348. 21. Dehner LP (ed): Pediatric Surgical Pathology . St Louis, CV Mosby Co, 1975, p 698. 22. Giacomoni MA, Volpi ML, Barberis M, et al: L'amartoma fibroso dell'infanzia . Minerva Chir 1986;41:1543-1545. 23. Napolitano L: The differentiation of white adipose cells: An electron microscopic study . J Cell Biol 1963;18:663-679.Crossref 24. Benjamin SP, Mercer RD, Hawk WA: Myofibroblastic contraction in spontaneous regression of multiple congenital mesenchymal hamartomas . Cancer 1977;40:2343-2352.Crossref 25. Enziger FM, Weiss SW: Fibrous proliferations of infancy and childhood , in Soft Tissue Tumors . St Louis, CV Mosby Co, 1983, pp 75-102. 26. Jennings TA, Duray PH, Collins FS, et al: Infantile myofibromatosis: Evidence for an autosomal dominant disorder . Am J Surg Pathol 1984;8:529-538.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Fibrous Hamartoma of Infancy: Eight Additional Cases and a Review of the Literature

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670130090013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fibrous hamartoma of infancy is a benign but persistent soft-tissue tumor that appears during the first two years of life. Although the lesion is not distinctive clinically, histopathologic examination of affected tissue reveals the three characteristic elements: fibrous, adipose, and myxoid mesenchymal tissue. Sixty-seven patients with fibrous hamartoma of infancy have been described previously, few in the dermatologic literature. In this report, we describe eight additional patients and present a compilation of the clinical statistics of all 75 cases. (Arch Dermatol 1989;125:88-91) References 1. Reye RDK: A consideration of certain subdermal `fibromatous tumours' of infancy . J Pathol 1956;72:149-154.Crossref 2. Mayayo Artal E, Mestres Caldentey M, Baeta Capellera J, et al: Hamartoma fibroso de la infancia, tumor de peculiar presentación a nivel escrotal . An Esp Pediatr 1986;25:136-138. 3. Enziger FM: Fibrous hamartoma of infancy . Cancer 1965;18:241-248.Crossref 4. Stout AP: Juvenile fibromatoses . Cancer 1954;7:953-978.Crossref 5. Allen AC: The Skin: A Clinicopathologic Treatise . St Louis, CV Mosby Co, 1954, p 943. 6. Greco MA, Schinella RA, Vuletin JC: Fibrous hamartoma of infancy: An ultrastructural study . Hum Pathol 1984;15:717-723.Crossref 7. Mitchell ML, Di Sant'Agnese PA, Gerber JE: Fibrous hamartoma of infancy . Hum Pathol 1982;13:586-588.Crossref 8. King DF, Barr RJ, Hirose FM: Fibrous hamartoma of infancy . J Dermatol Surg Oncol 1979;5:482-483.Crossref 9. Gang DL: Case 3: Fibrous hamartoma of infancy . Pediatr Pathol 1984;2:339-344.Crossref 10. Robbins LB, Hoffman S, Kahn S: Fibrous hamartoma of infancy . Plast Reconstr Surg 1970;46:197-200.Crossref 11. Gupta JC, Salgia KM, Sharma HSD: Fibrous hamartoma of infancy: A case report . Indian J Med Sci 1966;20:507-508. 12. Shimada K, Oomori M, Kobayashi S, et al: A case of fibrous hamartoma of infancy and review of the Japanese literature . Gan No Rinsho 1986;32:293-298. 13. Maung R, Lindsay R, Trevener C, et al: Fibrous hamartoma of infancy . Hum Pathol 1987;18:652-653.Crossref 14. Albukerk J, Wexler H, Dana M, et al: A case of fibrous hamartoma of infancy . J Pediatr Surg 1979;14:80-82.Crossref 15. Baarsma EA: Juvenile fibrous hamartoma of the pharynx . J Laryngol Otol 1979;93:75-79.Crossref 16. Goldstein SA, Imbriglia JE: Fibrous hamartoma of the wrist in infancy . J Hand Surg 1986;11A:847-849.Crossref 17. Harris CJ, Das S, Vogt PJ: Fibrous hamartoma of infancy in the scrotum . J Urol 1982;127:781-782. 18. Mehregan AH: Superficial fibrous tumors in childhood . J Cutan Pathol 1981;8:321-334.Crossref 19. Baselga C, Lario A, López MJ, et al: Hamartoma fibroso de pared costal: A propósito de un caso . An Esp Pediatr 1984;20:130-134. 20. Rosenberg HS, Stenback WA, Spjut HJ: The fibromatoses of infancy and childhood , in Rosenberg HS, Bolande RP (eds): Perspectives in Pediatric Pathology . Chicago, Year Book Medical Publishers Inc, 1978, pp 269-348. 21. Dehner LP (ed): Pediatric Surgical Pathology . St Louis, CV Mosby Co, 1975, p 698. 22. Giacomoni MA, Volpi ML, Barberis M, et al: L'amartoma fibroso dell'infanzia . Minerva Chir 1986;41:1543-1545. 23. Napolitano L: The differentiation of white adipose cells: An electron microscopic study . J Cell Biol 1963;18:663-679.Crossref 24. Benjamin SP, Mercer RD, Hawk WA: Myofibroblastic contraction in spontaneous regression of multiple congenital mesenchymal hamartomas . Cancer 1977;40:2343-2352.Crossref 25. Enziger FM, Weiss SW: Fibrous proliferations of infancy and childhood , in Soft Tissue Tumors . St Louis, CV Mosby Co, 1983, pp 75-102. 26. Jennings TA, Duray PH, Collins FS, et al: Infantile myofibromatosis: Evidence for an autosomal dominant disorder . Am J Surg Pathol 1984;8:529-538.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1989

References