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Fibrosis Cure?

Fibrosis Cure? Fibrosis in the liver can be stopped and even reversed in mice by giving them a peptide that blocks a protein associated with overproduction of scar tissue in the liver, according to research conducted at the University of California at San Diego School of Medicine and the Veterans Affairs San Diego Healthcare System (Buck M and Chojkier M. PLoS ONE. 2007;2[12]:e1372). The investigators discovered that the progression of liver fibrosis in mice depends on activation of a protein called ribosomal S6 kinase (RSK). They found that blocking RSK with an inhibitory peptide not only stopped the progression of fibrosis, it reversed some of the cell damage that had already occurred. The researchers discovered a similar activation of RSK in livers from patients with severe liver fibrosis but not in livers from healthy individuals. They noted that their data indicate that RSK is essential to the development of liver fibrosis and suggest a potential therapeutic target. The findings may be useful for treating conditions that lead to excessive liver scarring, such as viral hepatitis, fatty liver disease, and cirrhosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Fibrosis Cure?

Hampton, Tracy
JAMA , Volume 299 (5) – Feb 6, 2008
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Fibrosis Cure?

Abstract

Fibrosis in the liver can be stopped and even reversed in mice by giving them a peptide that blocks a protein associated with overproduction of scar tissue in the liver, according to research conducted at the University of California at San Diego School of Medicine and the Veterans Affairs San Diego Healthcare System (Buck M and Chojkier M. PLoS ONE. 2007;2[12]:e1372). The investigators discovered that the progression of liver fibrosis in mice depends on activation of a protein called...
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Publisher
American Medical Association
Copyright
Copyright © 2008 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.5.513-d
Publisher site
See Article on Publisher Site

Abstract

Fibrosis in the liver can be stopped and even reversed in mice by giving them a peptide that blocks a protein associated with overproduction of scar tissue in the liver, according to research conducted at the University of California at San Diego School of Medicine and the Veterans Affairs San Diego Healthcare System (Buck M and Chojkier M. PLoS ONE. 2007;2[12]:e1372). The investigators discovered that the progression of liver fibrosis in mice depends on activation of a protein called ribosomal S6 kinase (RSK). They found that blocking RSK with an inhibitory peptide not only stopped the progression of fibrosis, it reversed some of the cell damage that had already occurred. The researchers discovered a similar activation of RSK in livers from patients with severe liver fibrosis but not in livers from healthy individuals. They noted that their data indicate that RSK is essential to the development of liver fibrosis and suggest a potential therapeutic target. The findings may be useful for treating conditions that lead to excessive liver scarring, such as viral hepatitis, fatty liver disease, and cirrhosis.

Journal

JAMA – American Medical Association

Published: Feb 6, 2008

Keywords: fibrosis

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