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Fibroblast Development and Fibrogenesis: A Histochemical and Electron Microscope Study

Fibroblast Development and Fibrogenesis: A Histochemical and Electron Microscope Study Abstract Study of cultured fibroblasts on consecutive days of growth demonstrated them to be polymorphic cells capable of many forms and functions. On the fourth day of growth there is the formation of a well-developed endoplasmic reticulum and a marked folding of the cell membrane. Subsequently, filaments form intracellularly and are later released from the cell through the folds in the cell membrane. Following this, the filaments line up laterally and longitudinally in the extracellular space, thus giving rise to the striated collagen fibers. References 1. The supplier of Vestopal is Martin Jaeger, Spécialités pour Laboratoires, Vésenaz, Geneva, Switzerland. 2. Highberger, J. H.: Recent Advances in Knowledge of the Collagen Fibril and of the Properties of the Tropocollagen Macromolecule , J Amer Leather Chem Ass 56:422, 1961. 3. Chapman, J. A.: Morphological and Chemical Studies of Collagen Formation: I. The Fine Structure of Guinea Pig Granulomata , J Biophys Biochem Cytol 9:639, 1961.Crossref 4. Karrer, H. H.: Electron Microscope Study of Developing Chick Embryo Aorta , J Ultrastruct Res 4:420, 1960.Crossref 5. Yardley, J. H.; Heaton, M. W.; Gaines, M.; and Shulman, L. E.: Collagen Formation by Fibroblasts: Preliminary Electron Microscopic Observations Using Thin Sections of Tissue Cultures , Bull Hopkins Hosp 106:381, 1960. 6. Porter, K. E., and Pappas, G. D.: Collagen Formation by Fibroblasts of Chick Embryo Dermis , J Biophys Biochem Cytol 5:153, 1959.Crossref 7. Montagna, W.: The Structure and Function of Skin , New York: Academic Press, Inc., 1962. 8. Brachet, J., and Mirsky, A. E.: The Cell , New York: Academic Press, Inc., 1961, vol 2. 9. Palade, G. E.: The Endoplasmic Reticulum , J Biophys Biochem Cytol ( (suppl) ) 2:85, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Fibroblast Development and Fibrogenesis: A Histochemical and Electron Microscope Study

Archives of Dermatology , Volume 88 (5) – Nov 1, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590230005001
Publisher site
See Article on Publisher Site

Abstract

Abstract Study of cultured fibroblasts on consecutive days of growth demonstrated them to be polymorphic cells capable of many forms and functions. On the fourth day of growth there is the formation of a well-developed endoplasmic reticulum and a marked folding of the cell membrane. Subsequently, filaments form intracellularly and are later released from the cell through the folds in the cell membrane. Following this, the filaments line up laterally and longitudinally in the extracellular space, thus giving rise to the striated collagen fibers. References 1. The supplier of Vestopal is Martin Jaeger, Spécialités pour Laboratoires, Vésenaz, Geneva, Switzerland. 2. Highberger, J. H.: Recent Advances in Knowledge of the Collagen Fibril and of the Properties of the Tropocollagen Macromolecule , J Amer Leather Chem Ass 56:422, 1961. 3. Chapman, J. A.: Morphological and Chemical Studies of Collagen Formation: I. The Fine Structure of Guinea Pig Granulomata , J Biophys Biochem Cytol 9:639, 1961.Crossref 4. Karrer, H. H.: Electron Microscope Study of Developing Chick Embryo Aorta , J Ultrastruct Res 4:420, 1960.Crossref 5. Yardley, J. H.; Heaton, M. W.; Gaines, M.; and Shulman, L. E.: Collagen Formation by Fibroblasts: Preliminary Electron Microscopic Observations Using Thin Sections of Tissue Cultures , Bull Hopkins Hosp 106:381, 1960. 6. Porter, K. E., and Pappas, G. D.: Collagen Formation by Fibroblasts of Chick Embryo Dermis , J Biophys Biochem Cytol 5:153, 1959.Crossref 7. Montagna, W.: The Structure and Function of Skin , New York: Academic Press, Inc., 1962. 8. Brachet, J., and Mirsky, A. E.: The Cell , New York: Academic Press, Inc., 1961, vol 2. 9. Palade, G. E.: The Endoplasmic Reticulum , J Biophys Biochem Cytol ( (suppl) ) 2:85, 1956.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1963

References