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Fibrinogen in Liver Disease-Reply

Fibrinogen in Liver Disease-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—Dr. Fine and I would seem to agree that research should be directed at the endotoxin detoxifying capacity of the Kupffer cells of the liver. I am sure that my own results were performed on platelet-poor plasma, except where a platelet assay was being deliberately used, as in Fig 4 of my article. We also have looked into the report by Das et al and have found that it is the chloroform extraction technique that often gives a positive assay with platelet-rich plasma, whereas this is not so when the extraction of euglobulins and endotoxin inhibitors is performed by the acidification technique of Reinhold and Fine. We have therefore abandoned chloroform but still get similar assay levels in platelet-poor plasma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Fibrinogen in Liver Disease-Reply

Archives of Surgery , Volume 110 (7) – Jul 1, 1975

Fibrinogen in Liver Disease-Reply

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—Dr. Fine and I would seem to agree that research should be directed at the endotoxin detoxifying capacity of the Kupffer cells of the liver. I am sure that my own results were performed on platelet-poor plasma, except where a platelet assay was being deliberately used, as in Fig 4 of my article. We also have looked into the report by...
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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360130080025
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—Dr. Fine and I would seem to agree that research should be directed at the endotoxin detoxifying capacity of the Kupffer cells of the liver. I am sure that my own results were performed on platelet-poor plasma, except where a platelet assay was being deliberately used, as in Fig 4 of my article. We also have looked into the report by Das et al and have found that it is the chloroform extraction technique that often gives a positive assay with platelet-rich plasma, whereas this is not so when the extraction of euglobulins and endotoxin inhibitors is performed by the acidification technique of Reinhold and Fine. We have therefore abandoned chloroform but still get similar assay levels in platelet-poor plasma.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jul 1, 1975

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