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Fetal Damage due to Aminopterin Ingestion: Follow-up at 17½ Years of Age

Fetal Damage due to Aminopterin Ingestion: Follow-up at 17½ Years of Age Abstract In 1962, a female infant was delivered at 39 weeks' gestation to a mother who had attempted to induce abortion by ingesting an unknown amount of aminopterin sodium between days 55 and 58, with profound toxic effects, including epistaxis, loss of hair, and ulcerations of the mouth and skin. Failing to abort and realizing the danger of her fetus, she demanded an abortion but was refused. Her toxic symptoms subsided before delivery. The status of the child has been reported at birth, at 33 months, and at 9 years of age.1.2 This is an update on her amazing improvement at 17½ years of age. The Patient.—At birth her weight was 1,750 g, and her appearance resembled an identically injured neonate described by Warkany et al3 who had died at 24 hours of age. Our patient was not expected to live but improved after several days. Her globular References 1. Shaw EB, Steinbach HL: Aminopterin-induced fetal malformations: Survival of infant after attempted abortion . Am J Dis Child 115:477-482, 1968.Crossref 2. Shaw EB: Fetal damage due to maternal aminopterin ingestion: Follow-up at age 9 years . Am J Dis Child 124:93-94, 1972.Crossref 3. Warkany J, Beaudry PH, Hornstein S: Attempted abortion with aminopterin (4-aminopteroylglutamic acid): Malformations of the child . Am J Dis Child 97:274-281, 1959.Crossref 4. Reich EW, Cox RP, Becker MH, et al: Recognition in adult patients of malformations induced by folic acid antagonists . Birth Defects 14:139-160, 1978. 5. Meltzer HJ: Congenital anomalies due to attempted abortion with 4-aminopteroglutamic acid . JAMA 161:1253, 1956.Crossref 6. Brandner M, Nussle D: Foetopathie due à l'aminoptérine avec sténose congénitale de l'espace médullaire des os tubulaires ongs . Ann Radiol 12:705-710, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Fetal Damage due to Aminopterin Ingestion: Follow-up at 17½ Years of Age

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130240052015
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1962, a female infant was delivered at 39 weeks' gestation to a mother who had attempted to induce abortion by ingesting an unknown amount of aminopterin sodium between days 55 and 58, with profound toxic effects, including epistaxis, loss of hair, and ulcerations of the mouth and skin. Failing to abort and realizing the danger of her fetus, she demanded an abortion but was refused. Her toxic symptoms subsided before delivery. The status of the child has been reported at birth, at 33 months, and at 9 years of age.1.2 This is an update on her amazing improvement at 17½ years of age. The Patient.—At birth her weight was 1,750 g, and her appearance resembled an identically injured neonate described by Warkany et al3 who had died at 24 hours of age. Our patient was not expected to live but improved after several days. Her globular References 1. Shaw EB, Steinbach HL: Aminopterin-induced fetal malformations: Survival of infant after attempted abortion . Am J Dis Child 115:477-482, 1968.Crossref 2. Shaw EB: Fetal damage due to maternal aminopterin ingestion: Follow-up at age 9 years . Am J Dis Child 124:93-94, 1972.Crossref 3. Warkany J, Beaudry PH, Hornstein S: Attempted abortion with aminopterin (4-aminopteroylglutamic acid): Malformations of the child . Am J Dis Child 97:274-281, 1959.Crossref 4. Reich EW, Cox RP, Becker MH, et al: Recognition in adult patients of malformations induced by folic acid antagonists . Birth Defects 14:139-160, 1978. 5. Meltzer HJ: Congenital anomalies due to attempted abortion with 4-aminopteroglutamic acid . JAMA 161:1253, 1956.Crossref 6. Brandner M, Nussle D: Foetopathie due à l'aminoptérine avec sténose congénitale de l'espace médullaire des os tubulaires ongs . Ann Radiol 12:705-710, 1969.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1980

References

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