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Fetal AIDS Syndrome Score: Correlation Between Severity of Dysmorphism and Age at Diagnosis of Immunodeficiency

Fetal AIDS Syndrome Score: Correlation Between Severity of Dysmorphism and Age at Diagnosis of... Abstract • To objectively evaluate the fetal acquired immunodeficiency syndrome, we have developed a scoring system based on the presence of the characteristic features that we have previously reported. Using this scoring system, 37 children seropositive for the human immunodeficiency virus were classified into three groups: (1) dysmorphologically severely affected (12 children); (2) moderately affected (15 children); and (3) mildly affected (ten children). There was a statistically significant correlation between the severity of the dysmorphic features and both the presence of opportunistic infections within the first year of life and the age at onset of symptoms associated with immune dysfunction, with the more severely stigmatized children manifesting symptoms at a younger age. There was no correlation, however, between severity of the dysmorphic features and presence of opportunistic infections at the time of our examination. We conclude that this scoring system may be useful in presymptomatic identification of severely dysmorphic human immunodeficiency virus—infected infants. (AJDC 1987;141:429-431) References 1. Marion RW, Wiznia AA, Hutcheon RG, et al: Human T-cell lymphotropic virus type III (HTLV-III) embryopathy . AJDC 1986;140: 638-640. 2. Sarngadharan MG, Popovic M, Bruch L, et al: antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS . Science 1984;224:506-508.Crossref 3. Schuepbach J, Sarngadharan MG, Gallo R, et al: Antigens on HTLV-III infected cells recognized by leukemia and AIDS sera are related to HTLV viral glycoprotein . Science 1984;224:607-609.Crossref 4. Update: Acquired immunodeficiency syndrome (AIDS)—United States . MMWR 1984;32: 688-691. 5. Rubinstein A, Morecki R, Silverman B, et al: Pulmonary disease in children with AIDS and ARC . J Pediatr 1986;108:498-502.Crossref 6. Rubinstein A: Acquired immunodeficiency syndrome in infants . AJDC 1983;137:825-827. 7. Scott GB, Buck BE, Leterman JG, et al: Acquired immunodeficiency syndrome in infants . N Engl J Med 1984;310:76-81.Crossref 8. Logothetis J, Economidu J, Constantoulakis S, et al: Cephalofacial deformities in thalassemia major (Cooley's anemia) . AJDC 1971;121:300-304. 9. Spranger J, Bernischke K, Hall JG, et al: Errors of morphogenesis: Concepts and terms . J Pediatr 1982;100:160-165.Crossref 10. Warkany J, Kalter H: Congenital malformations . N Engl J Med 1961;265:993-999.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Fetal AIDS Syndrome Score: Correlation Between Severity of Dysmorphism and Age at Diagnosis of Immunodeficiency

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460040087022
Publisher site
See Article on Publisher Site

Abstract

Abstract • To objectively evaluate the fetal acquired immunodeficiency syndrome, we have developed a scoring system based on the presence of the characteristic features that we have previously reported. Using this scoring system, 37 children seropositive for the human immunodeficiency virus were classified into three groups: (1) dysmorphologically severely affected (12 children); (2) moderately affected (15 children); and (3) mildly affected (ten children). There was a statistically significant correlation between the severity of the dysmorphic features and both the presence of opportunistic infections within the first year of life and the age at onset of symptoms associated with immune dysfunction, with the more severely stigmatized children manifesting symptoms at a younger age. There was no correlation, however, between severity of the dysmorphic features and presence of opportunistic infections at the time of our examination. We conclude that this scoring system may be useful in presymptomatic identification of severely dysmorphic human immunodeficiency virus—infected infants. (AJDC 1987;141:429-431) References 1. Marion RW, Wiznia AA, Hutcheon RG, et al: Human T-cell lymphotropic virus type III (HTLV-III) embryopathy . AJDC 1986;140: 638-640. 2. Sarngadharan MG, Popovic M, Bruch L, et al: antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS . Science 1984;224:506-508.Crossref 3. Schuepbach J, Sarngadharan MG, Gallo R, et al: Antigens on HTLV-III infected cells recognized by leukemia and AIDS sera are related to HTLV viral glycoprotein . Science 1984;224:607-609.Crossref 4. Update: Acquired immunodeficiency syndrome (AIDS)—United States . MMWR 1984;32: 688-691. 5. Rubinstein A, Morecki R, Silverman B, et al: Pulmonary disease in children with AIDS and ARC . J Pediatr 1986;108:498-502.Crossref 6. Rubinstein A: Acquired immunodeficiency syndrome in infants . AJDC 1983;137:825-827. 7. Scott GB, Buck BE, Leterman JG, et al: Acquired immunodeficiency syndrome in infants . N Engl J Med 1984;310:76-81.Crossref 8. Logothetis J, Economidu J, Constantoulakis S, et al: Cephalofacial deformities in thalassemia major (Cooley's anemia) . AJDC 1971;121:300-304. 9. Spranger J, Bernischke K, Hall JG, et al: Errors of morphogenesis: Concepts and terms . J Pediatr 1982;100:160-165.Crossref 10. Warkany J, Kalter H: Congenital malformations . N Engl J Med 1961;265:993-999.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1987

References