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Fertility Prospects for Children With Cryptorchidism

Fertility Prospects for Children With Cryptorchidism Abstract • One hundred forty-five men had undergone surgical correction of cryptorchid testes between 1936 and 1968. Eighty percent of 100 patients with unilateral cryptorchidism and 35% (16/45) of patients with bilateral cryptorchidism had reported fertility after 12 or more years of follow-up. There was no significant difference between the fertility rates of patients treated with or without preoperative human chorionic gonadotropin. These data serve to challenge other published series and the popular assumption that there is an inherent bilateral testicular defect in most patients with unilateral cryptorchidism. (AJDC 1984;138:940-943) References 1. Lipshultz LI: Cryptorchidism in the subfertile male . Fertil Steril 1976;27:609-620. 2. Hansen TS: Fertility in operatively treated and untreated cryptorchidism . Proc R Soc Med 1949;42:645-665. 3. Hellinga G: Fertility after hormonal or surgical treatment for bilateral cryptorchidism . Organorama 1966;3:4-6. 4. Mack WS: Discussion of male fertility . Proc R Soc Med 1953;46:840-843. 5. Schirren C: The spermatogram of hormonetreated patients and of surgical treated patients with maldescended testicles . Bull Osaka Med Schl 1964;10:120-128. 6. Retief PJM: Fertility in undescended testes . S Afr Med J 1977;52:610-613. 7. Ludwig G, Potempa J: Der optimale Zeitpunkt der Behandlung des Kryptorchismus . Dtsch Med Wochenschr 1975;100:680-683.Crossref 8. Richter W, Proschold M, Butenandt O, et al: Die fertilitat nach HCG: Behandlung des maldescensus testes . Klin Wochenschr 1976;54:467-473.Crossref 9. Hecker WC, Heinz HA: Cryptorchidism and fertility . J Pediatr Surg 1967;2:513-517.Crossref 10. Gross RE, Jewett TC: Surgical experiences from 1,222 operations for undescended testes . JAMA 1956;160:634-664.Crossref 11. Brunet J, DeMowbray RR, Bishop PMF: Management of the undescended testes . Br Med J 1958;1:1367-1370.Crossref 12. Charney CW: The spermatogenic potential of the undescended testis before and after treatment . J Urol 1960;83:697-705. 13. Atkinson PM: A follow up study of surgically treated cryptorchid patients . J Pediatr Surg 1975;10:115-119.Crossref 14. Fertility of American Women: June 1977 . US Dept of Commerce Bureau of the Census, series 20, No. (325) , September 1978, p 32. 15. Kiesewetter WB, Shull WR, Fetterman GH: Histologic changes in the testes following anatomically successful orchiopexy . J Pediatr Surg 1969;4:59-65.Crossref 16. Scott LS: Fertility in cryptorchidism . Proc R Soc Med 1962;55:1047-1050. 17. Nicole R, Spindler B: Prognosis as to fertility following operations for cryptorchidism in children . Organorama 1966;3:6-8. 18. Giarola A: The undescended testicle: Therapeutical aspects from the standpoint of reproductive life . Organorama 1966;3:9-10. 19. Scott LS: Unilateral cryptorchidism subsequent effect on fertility . J Reprod Fertil 1961;2: 54-60.Crossref 20. Woodhead DM, Pohl DR, Johnson DE: Fertility of patients with solitary testes . J Urol 1973;109:66-67. 21. Mengel W, Heinz HA, Sippe WG II, et al: Studies on cryptorchidism: A comparison of histological findings in the germinative epithelium before and after the second year of life . J Pediatr Surg 1974;9:445-450.Crossref 22. Farrington GH: Histologic observation in cryptorchidism: The congenital germinal-cell deficiency of the undescended testis . J Pediatr Surg 1969;4:606-613.Crossref 23. Markewitz M, Lattimer JK, Veenema RJ: A comparative study of germ cell kinetics in the testes of children with unilateral cryptorchidism: A preliminary report . Fertil Steril 1970;21:806-815. 24. Mininberg DT, Bingol N: Chromosomal abnormalities in undescended testes . Urology 1973;1:98-101.Crossref 25. Dewald CW, Kelalis PP, Gordon H: Chromosomal studies in cryptorchidism . J Urol 1977; 117:110-112. 26. Klugo R, van Dyke DL, Weiss L: Cytogenic studies of cryptorchid testes . Urology 1978; 11:255-266.Crossref 27. Waaler PE: Clinical and cytogenic studies in undescended testes . Acta Paediatr Scand 1976; 65:553-558.Crossref 28. Bramble FJ, Houghton AL, Eccles S, et al: Reproductive and endocrine function after surgical treatment of bilateral cryptorchidism . Lancet 1974;2:311-314.Crossref 29. Fonkalsruds EW: The undescended testes . Curr Probl Surg 1978;15:3-56. 30. Albescu JZ, Bergada C, Cullen M: Male fertility in patients treated for cryptorchidism before puberty . Fertil Steril 1971;22:829-833. 31. Czaplicki M, Bablok L, Janczewski Z: Fertility after treatment of bilateral cryptorchidism . Int Urol Nephrol 1974;6:259-261.Crossref 32. MacCollum DW: Clinical study of the spermatogenesis of undescended testicles . Arch Surg 1935;31:290-300.Crossref 33. Rea CE: Fertility in cryptorchids . Minn Med 1951;34:216-217. 34. Maitland AL: Maldescent of the testicle . Glasgow Med J 1953;34:170-179. 35. Hand JR: Undescended testes: Report of 153 cases with evaluation of clinical findings, treatment and results of follow-up to 33 years . Trans Am Assoc Genurin Surg 1955;47:9-50. 36. Carver JH: Bilateral orchiopexy and fertility . Proc R Soc Med 1958;51:328-330. 37. Bergstrand CG, Quist O: in Lenneiveh F (ed): Die Prognose Chronischer Erkrankungen . Berlin, Heidelberg, 1960, p 254. 38. Hortling H, de la Chappele A, Johansson CJ, et al: Endocrinologic follow-up study of operated cases of cryptorchidism . J Endocrinol Metabol 1967;27:120-129.Crossref 39. Wojciechowski K, Rucki T, Walzak M, et al: Long-term results of undescended testicle operative treatment . Prog Pediatr Surg 1977;10:297-304. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Fertility Prospects for Children With Cryptorchidism

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1984.02140480041013
Publisher site
See Article on Publisher Site

Abstract

Abstract • One hundred forty-five men had undergone surgical correction of cryptorchid testes between 1936 and 1968. Eighty percent of 100 patients with unilateral cryptorchidism and 35% (16/45) of patients with bilateral cryptorchidism had reported fertility after 12 or more years of follow-up. There was no significant difference between the fertility rates of patients treated with or without preoperative human chorionic gonadotropin. These data serve to challenge other published series and the popular assumption that there is an inherent bilateral testicular defect in most patients with unilateral cryptorchidism. (AJDC 1984;138:940-943) References 1. Lipshultz LI: Cryptorchidism in the subfertile male . Fertil Steril 1976;27:609-620. 2. Hansen TS: Fertility in operatively treated and untreated cryptorchidism . Proc R Soc Med 1949;42:645-665. 3. Hellinga G: Fertility after hormonal or surgical treatment for bilateral cryptorchidism . Organorama 1966;3:4-6. 4. Mack WS: Discussion of male fertility . Proc R Soc Med 1953;46:840-843. 5. Schirren C: The spermatogram of hormonetreated patients and of surgical treated patients with maldescended testicles . Bull Osaka Med Schl 1964;10:120-128. 6. Retief PJM: Fertility in undescended testes . S Afr Med J 1977;52:610-613. 7. Ludwig G, Potempa J: Der optimale Zeitpunkt der Behandlung des Kryptorchismus . Dtsch Med Wochenschr 1975;100:680-683.Crossref 8. Richter W, Proschold M, Butenandt O, et al: Die fertilitat nach HCG: Behandlung des maldescensus testes . Klin Wochenschr 1976;54:467-473.Crossref 9. Hecker WC, Heinz HA: Cryptorchidism and fertility . J Pediatr Surg 1967;2:513-517.Crossref 10. Gross RE, Jewett TC: Surgical experiences from 1,222 operations for undescended testes . JAMA 1956;160:634-664.Crossref 11. Brunet J, DeMowbray RR, Bishop PMF: Management of the undescended testes . Br Med J 1958;1:1367-1370.Crossref 12. Charney CW: The spermatogenic potential of the undescended testis before and after treatment . J Urol 1960;83:697-705. 13. Atkinson PM: A follow up study of surgically treated cryptorchid patients . J Pediatr Surg 1975;10:115-119.Crossref 14. Fertility of American Women: June 1977 . US Dept of Commerce Bureau of the Census, series 20, No. (325) , September 1978, p 32. 15. Kiesewetter WB, Shull WR, Fetterman GH: Histologic changes in the testes following anatomically successful orchiopexy . J Pediatr Surg 1969;4:59-65.Crossref 16. Scott LS: Fertility in cryptorchidism . Proc R Soc Med 1962;55:1047-1050. 17. Nicole R, Spindler B: Prognosis as to fertility following operations for cryptorchidism in children . Organorama 1966;3:6-8. 18. Giarola A: The undescended testicle: Therapeutical aspects from the standpoint of reproductive life . Organorama 1966;3:9-10. 19. Scott LS: Unilateral cryptorchidism subsequent effect on fertility . J Reprod Fertil 1961;2: 54-60.Crossref 20. Woodhead DM, Pohl DR, Johnson DE: Fertility of patients with solitary testes . J Urol 1973;109:66-67. 21. Mengel W, Heinz HA, Sippe WG II, et al: Studies on cryptorchidism: A comparison of histological findings in the germinative epithelium before and after the second year of life . J Pediatr Surg 1974;9:445-450.Crossref 22. Farrington GH: Histologic observation in cryptorchidism: The congenital germinal-cell deficiency of the undescended testis . J Pediatr Surg 1969;4:606-613.Crossref 23. Markewitz M, Lattimer JK, Veenema RJ: A comparative study of germ cell kinetics in the testes of children with unilateral cryptorchidism: A preliminary report . Fertil Steril 1970;21:806-815. 24. Mininberg DT, Bingol N: Chromosomal abnormalities in undescended testes . Urology 1973;1:98-101.Crossref 25. Dewald CW, Kelalis PP, Gordon H: Chromosomal studies in cryptorchidism . J Urol 1977; 117:110-112. 26. Klugo R, van Dyke DL, Weiss L: Cytogenic studies of cryptorchid testes . Urology 1978; 11:255-266.Crossref 27. Waaler PE: Clinical and cytogenic studies in undescended testes . Acta Paediatr Scand 1976; 65:553-558.Crossref 28. Bramble FJ, Houghton AL, Eccles S, et al: Reproductive and endocrine function after surgical treatment of bilateral cryptorchidism . Lancet 1974;2:311-314.Crossref 29. Fonkalsruds EW: The undescended testes . Curr Probl Surg 1978;15:3-56. 30. Albescu JZ, Bergada C, Cullen M: Male fertility in patients treated for cryptorchidism before puberty . Fertil Steril 1971;22:829-833. 31. Czaplicki M, Bablok L, Janczewski Z: Fertility after treatment of bilateral cryptorchidism . Int Urol Nephrol 1974;6:259-261.Crossref 32. MacCollum DW: Clinical study of the spermatogenesis of undescended testicles . Arch Surg 1935;31:290-300.Crossref 33. Rea CE: Fertility in cryptorchids . Minn Med 1951;34:216-217. 34. Maitland AL: Maldescent of the testicle . Glasgow Med J 1953;34:170-179. 35. Hand JR: Undescended testes: Report of 153 cases with evaluation of clinical findings, treatment and results of follow-up to 33 years . Trans Am Assoc Genurin Surg 1955;47:9-50. 36. Carver JH: Bilateral orchiopexy and fertility . Proc R Soc Med 1958;51:328-330. 37. Bergstrand CG, Quist O: in Lenneiveh F (ed): Die Prognose Chronischer Erkrankungen . Berlin, Heidelberg, 1960, p 254. 38. Hortling H, de la Chappele A, Johansson CJ, et al: Endocrinologic follow-up study of operated cases of cryptorchidism . J Endocrinol Metabol 1967;27:120-129.Crossref 39. Wojciechowski K, Rucki T, Walzak M, et al: Long-term results of undescended testicle operative treatment . Prog Pediatr Surg 1977;10:297-304.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1984

References

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