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Febrile Convulsions and Later Development of Epilepsy

Febrile Convulsions and Later Development of Epilepsy Abstract • A group of 172 epileptic children who had had prior febrile convulsions was compared with a group of 674 who had not. Children with epilepsy and prior febrile convulsions were similar in some respects (sex ratio, positive family history for seizures) to children with pure febrile convulsions and in most respects (type of epilepsy, mental status, initial EEG, and two- and four-year remission rates in the long-term outcome) to epileptic children without prior febrile convulsions. Our data do not support the current view that febrile convulsions, per se, are the main cause of mesial temporal sclerosis, ie, temporal lobe epilepsy. Thus, our clinical findings support previously expressed doubts on the role of febrile seizures in temporal lobe epilepsy that were based on pathohistologic findings. (Am J Dis Child 1983;137:123-126) References 1. Buchanan D: Convulsions in infancy and childhood . Med Clin North Am 1946;30:163-172. 2. Bridge EM: Epilepsy and Convulsive Disorders in Children . New York, McGraw-Hill Book Co, 1949. 3. Lennox WG: Significance of febrile convulsions . Pediatrics 1953;11:341-357. 4. Bjerglund R, Brandt S: Electroencefalografiske Fund hos Børn med 'Febrile Cramper.' Ugeskr Laeger 1954;116:1423-1431. 5. Gibbs FA, Low NL: Electroencephalography in children . Pediatr Clin North Am 1955;2: 291-303. 6. Breg W, Yannet H: The child in a convulsion . Pediatr Clin North Am 1962;9:101-114. 7. Gastaut H: Classification of the epilepsies . Epilepsia 1969;10( (suppl) ):14-21. 8. Aicardi J, Chevrie J-J: Febrile convulsions: Neurological sequelae and mental retardation , in Brazier MAB, Coceani F (eds): Brain Disfunction in Infantile Febrile Convulsions . New York, Raven Press, 1976, pp 247-257. 9. Nelson KB, Ellenberg JH: Predictors of epilepsy in children who have experienced febrile seizures . New Engl J Med 1976;295:1029-1033.Crossref 10. Lennox M: Febrile convulsions in childhood: Their relationship to adult epilepsy . J Pediatr 1949;35:427-435.Crossref 11. Pascual R, McGovern JP: Febrile convulsions in childhood . Clin Proc Child Hosp Natl Med Cntr 1952;8:92-98. 12. Millichap GJ: Febrile convulsions . New York, McMillan Publishing Co Inc, 1968. 13. Thorn I: Round table discussion on febrile convulsions . Epilepsia 1971;12:191-194.Crossref 14. Ouellette EM: The child who convulses with fever . Pediatr Clin North Am 1974;21: 467-481. 15. Hrbek A: Fieberkrämpfe im Kindesalter . Ann Pediatr 1957;188:162-182. 16. Stevens A: Données electroencephalographiques dans les convulsions febriles essentielles du jeune enfant . Rev Med Liege 1957;12: 675-681. 17. Millichap JG, Madsen JA, Aledort LM: Studies in febrile seizures: V. A clinical and electroencephalographic study in unselected patients . Neurology 1960;10:643-653.Crossref 18. Oller-Daurella L, Marquez J: Las crisis febriles y los status hipertermicos . Rev Esp Pediatr 1968;139:1-26. 19. Lennox-Buchthal M: Febrile convulsions: A reappraisal . Electroencephalographr Clin Neurophysiol Suppl 1973;32:1-132. 20. Wallace JS: Spontaneous fits after convulsions with fever . Arch Dis Child 1977;52:192-196.Crossref 21. Falconer MA, Serafinides EA, Corsellis JAN: Etiology and pathogenesis of temporal lobe epilepsy . Arch Neurol 1964;10:233-248.Crossref 22. Ounsted C, Lindsay J, Norman R: Biological Factors in Temporal Lobe Epilepsy , London, William Heinemann Medical Books, 1966. 23. Falconer MA: Genetic and related aetiological factors in temporal lobe epilepsy: A review . Epilepsia 1971;12:13-31.Crossref 24. Lindsay JMM: Genetics and epilepsy: A model from critical path analysis . Epilepsia 1971;12:47-54.Crossref 25. Taylor DC, Ounsted C: Biological mechanism influencing the outcome of seizures in response to fever . Epilepsia 1971;12:33-45.Crossref 26. Meldrum BS, Brierley JB: Prolonged epileptic seizures in primates: Ischemic cell change and its relation to ictal physiological events . Arch Neurol 1973;28:10-17.Crossref 27. Davidson S, Falconer MA: Outcome of surgery in 400 children with temporal lobe epilepsy . Lancet 1975;1:1260-1263.Crossref 28. Meldrum BS: Secondary pathology of febrile and experimental convulsions , in Brazier MAB, Coceani F (eds): Brain Disfunction in Infantile Febrile Convulsions . New York, Raven Press, 1976, pp 213-222. 29. Lindsay J, Ounstedt C, Richards P: Long-term outcome in children with temporal lobe seizures: IV. Genetic factors, febrile convulsions and the remission of seizures . Dev Med Child Neurol 1980;22:429-439.Crossref 30. Scheibel AB: Seizure related changes in brain structure , in Wada JA, Penry JK (eds): Advances in Epileptology: The Tenth Epilepsy International Symposium . New York, Raven Press, 1980, pp 19-26. 31. Ellenberg JH, Nelson KB: Febrile seizures and later intellectual performance . Arch Neurol 1978;35:17-21.Crossref 32. Nelson KB, Ellenberg JH: Prognosis in children with febrile seizures . Pediatrics 1978;61: 720-727. 33. NIH consensus development conference summary: Consensus statement on febrile seizures , in Nelson KB, Ellenberg JH (eds): Febrile Seizures . New York, Raven Press, pp 301-306. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Febrile Convulsions and Later Development of Epilepsy

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References (38)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1983.02140280021006
Publisher site
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Abstract

Abstract • A group of 172 epileptic children who had had prior febrile convulsions was compared with a group of 674 who had not. Children with epilepsy and prior febrile convulsions were similar in some respects (sex ratio, positive family history for seizures) to children with pure febrile convulsions and in most respects (type of epilepsy, mental status, initial EEG, and two- and four-year remission rates in the long-term outcome) to epileptic children without prior febrile convulsions. Our data do not support the current view that febrile convulsions, per se, are the main cause of mesial temporal sclerosis, ie, temporal lobe epilepsy. Thus, our clinical findings support previously expressed doubts on the role of febrile seizures in temporal lobe epilepsy that were based on pathohistologic findings. (Am J Dis Child 1983;137:123-126) References 1. Buchanan D: Convulsions in infancy and childhood . Med Clin North Am 1946;30:163-172. 2. Bridge EM: Epilepsy and Convulsive Disorders in Children . New York, McGraw-Hill Book Co, 1949. 3. Lennox WG: Significance of febrile convulsions . Pediatrics 1953;11:341-357. 4. Bjerglund R, Brandt S: Electroencefalografiske Fund hos Børn med 'Febrile Cramper.' Ugeskr Laeger 1954;116:1423-1431. 5. Gibbs FA, Low NL: Electroencephalography in children . Pediatr Clin North Am 1955;2: 291-303. 6. Breg W, Yannet H: The child in a convulsion . Pediatr Clin North Am 1962;9:101-114. 7. Gastaut H: Classification of the epilepsies . Epilepsia 1969;10( (suppl) ):14-21. 8. Aicardi J, Chevrie J-J: Febrile convulsions: Neurological sequelae and mental retardation , in Brazier MAB, Coceani F (eds): Brain Disfunction in Infantile Febrile Convulsions . New York, Raven Press, 1976, pp 247-257. 9. Nelson KB, Ellenberg JH: Predictors of epilepsy in children who have experienced febrile seizures . New Engl J Med 1976;295:1029-1033.Crossref 10. Lennox M: Febrile convulsions in childhood: Their relationship to adult epilepsy . J Pediatr 1949;35:427-435.Crossref 11. Pascual R, McGovern JP: Febrile convulsions in childhood . Clin Proc Child Hosp Natl Med Cntr 1952;8:92-98. 12. Millichap GJ: Febrile convulsions . New York, McMillan Publishing Co Inc, 1968. 13. Thorn I: Round table discussion on febrile convulsions . Epilepsia 1971;12:191-194.Crossref 14. Ouellette EM: The child who convulses with fever . Pediatr Clin North Am 1974;21: 467-481. 15. Hrbek A: Fieberkrämpfe im Kindesalter . Ann Pediatr 1957;188:162-182. 16. Stevens A: Données electroencephalographiques dans les convulsions febriles essentielles du jeune enfant . Rev Med Liege 1957;12: 675-681. 17. Millichap JG, Madsen JA, Aledort LM: Studies in febrile seizures: V. A clinical and electroencephalographic study in unselected patients . Neurology 1960;10:643-653.Crossref 18. Oller-Daurella L, Marquez J: Las crisis febriles y los status hipertermicos . Rev Esp Pediatr 1968;139:1-26. 19. Lennox-Buchthal M: Febrile convulsions: A reappraisal . Electroencephalographr Clin Neurophysiol Suppl 1973;32:1-132. 20. Wallace JS: Spontaneous fits after convulsions with fever . Arch Dis Child 1977;52:192-196.Crossref 21. Falconer MA, Serafinides EA, Corsellis JAN: Etiology and pathogenesis of temporal lobe epilepsy . Arch Neurol 1964;10:233-248.Crossref 22. Ounsted C, Lindsay J, Norman R: Biological Factors in Temporal Lobe Epilepsy , London, William Heinemann Medical Books, 1966. 23. Falconer MA: Genetic and related aetiological factors in temporal lobe epilepsy: A review . Epilepsia 1971;12:13-31.Crossref 24. Lindsay JMM: Genetics and epilepsy: A model from critical path analysis . Epilepsia 1971;12:47-54.Crossref 25. Taylor DC, Ounsted C: Biological mechanism influencing the outcome of seizures in response to fever . Epilepsia 1971;12:33-45.Crossref 26. Meldrum BS, Brierley JB: Prolonged epileptic seizures in primates: Ischemic cell change and its relation to ictal physiological events . Arch Neurol 1973;28:10-17.Crossref 27. Davidson S, Falconer MA: Outcome of surgery in 400 children with temporal lobe epilepsy . Lancet 1975;1:1260-1263.Crossref 28. Meldrum BS: Secondary pathology of febrile and experimental convulsions , in Brazier MAB, Coceani F (eds): Brain Disfunction in Infantile Febrile Convulsions . New York, Raven Press, 1976, pp 213-222. 29. Lindsay J, Ounstedt C, Richards P: Long-term outcome in children with temporal lobe seizures: IV. Genetic factors, febrile convulsions and the remission of seizures . Dev Med Child Neurol 1980;22:429-439.Crossref 30. Scheibel AB: Seizure related changes in brain structure , in Wada JA, Penry JK (eds): Advances in Epileptology: The Tenth Epilepsy International Symposium . New York, Raven Press, 1980, pp 19-26. 31. Ellenberg JH, Nelson KB: Febrile seizures and later intellectual performance . Arch Neurol 1978;35:17-21.Crossref 32. Nelson KB, Ellenberg JH: Prognosis in children with febrile seizures . Pediatrics 1978;61: 720-727. 33. NIH consensus development conference summary: Consensus statement on febrile seizures , in Nelson KB, Ellenberg JH (eds): Febrile Seizures . New York, Raven Press, pp 301-306.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Feb 1, 1983

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