Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Fatigue in Multiple Sclerosis

Fatigue in Multiple Sclerosis Abstract • Fatigue is a frequent symptom in multiple sclerosis (MS) that can interfere with a patient's daily functioning. The cause of MS fatigue, its clinical characteristics, and its relationship to other symptoms remain poorly understood. Structured interviews were conducted with 32 patients with MS and 33 normal healthy adults. Fatigue proved to be both more frequent and more severe among the patients with MS. Multiple sclerosis fatigue was unrelated to either depression or global impairment. Multiple sclerosis fatigue appears to be a distinct clinical entity, often disabling, that can be distinguished from normal fatigue, affective disturbance, and neurologic impairment. References 1. Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis . Arch Phys Med Rehabil 1984;65:135-138. 2. Murray TJ: Amantadine therapy for fatigue in multiple sclerosis . Can J Neurol Sci 1985;12:251-254. 3. Schumacher GA, Beebe G, Kibler RF, et al: Problems of experimental trials of therapy in multiple sclerosis: Report by the panel of the evaluation of experimental trials in multiple sclerosis . Ann NY Acad Sci 1965;122:552-568.Crossref 4. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS) . Neurology 1983;11:1444-1452.Crossref 5. Scott PJ, Huskisson EC: Measurement of functional capacity with visual analogue scales . Rheumatol Rehabil 1977;16:257-259.Crossref 6. Radloff LS: CES-D scale: A self-report depression scale for research in the general population . Appl Psychol Meas 1977;1:385-401.Crossref 7. Whitlock FA, Siskind MM: Depression as a major symptom of multiple sclerosis . J Neurol Neurosurg Psychiatry 1980;43:861-865.Crossref 8. Rabins PV, Brooks BR, O'Donnel P, et al: Structural brain correlates of emotional disorder in multiple sclerosis . Brain 1986;109:585-587.Crossref 9. Joffe RT, Lippert GP, Gray TA, et al: Mood disorder and multiple sclerosis . Arch Neurol 1987;44:376-378.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Loading next page...
 
/lp/american-medical-association/fatigue-in-multiple-sclerosis-jD8qmJsN6r
Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1988.00520280085020
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fatigue is a frequent symptom in multiple sclerosis (MS) that can interfere with a patient's daily functioning. The cause of MS fatigue, its clinical characteristics, and its relationship to other symptoms remain poorly understood. Structured interviews were conducted with 32 patients with MS and 33 normal healthy adults. Fatigue proved to be both more frequent and more severe among the patients with MS. Multiple sclerosis fatigue was unrelated to either depression or global impairment. Multiple sclerosis fatigue appears to be a distinct clinical entity, often disabling, that can be distinguished from normal fatigue, affective disturbance, and neurologic impairment. References 1. Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis . Arch Phys Med Rehabil 1984;65:135-138. 2. Murray TJ: Amantadine therapy for fatigue in multiple sclerosis . Can J Neurol Sci 1985;12:251-254. 3. Schumacher GA, Beebe G, Kibler RF, et al: Problems of experimental trials of therapy in multiple sclerosis: Report by the panel of the evaluation of experimental trials in multiple sclerosis . Ann NY Acad Sci 1965;122:552-568.Crossref 4. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS) . Neurology 1983;11:1444-1452.Crossref 5. Scott PJ, Huskisson EC: Measurement of functional capacity with visual analogue scales . Rheumatol Rehabil 1977;16:257-259.Crossref 6. Radloff LS: CES-D scale: A self-report depression scale for research in the general population . Appl Psychol Meas 1977;1:385-401.Crossref 7. Whitlock FA, Siskind MM: Depression as a major symptom of multiple sclerosis . J Neurol Neurosurg Psychiatry 1980;43:861-865.Crossref 8. Rabins PV, Brooks BR, O'Donnel P, et al: Structural brain correlates of emotional disorder in multiple sclerosis . Brain 1986;109:585-587.Crossref 9. Joffe RT, Lippert GP, Gray TA, et al: Mood disorder and multiple sclerosis . Arch Neurol 1987;44:376-378.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Apr 1, 1988

References