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Fatal Pneumonia Associated With Adenovirus Type 7

Fatal Pneumonia Associated With Adenovirus Type 7 Abstract THE ASSOCIATION of adenoviruses with fatal disease in children has been noted in many parts of the world by several investigators.1-10 In view of the ability of this group of viruses to establish latent infection in various body tissues, including the lung,11 Sohier et al have recently proposed12 that even the recovery of these viruses from postmortem material is not definitive in establishing an etiological association with the patient's death. These workers would also require evidence of viral multiplication in affected organs. Such criteria have been fulfilled in the case we are presenting of a 10-month-old girl who died of severe pneumonia. Adenovirus type 7 was isolated not only from her stool, but also in high titer from her lungs and pericardial fluid. Histopathological changes consistent with adenovirus infection were observed in postmortem lung tissue. In addition, by the use of electron microscopy, viral particles morphologically consistent References 1. Pereira, H.G., and Kelly, B.: Studies on Natural and Experimental Infections by Adenovirus , Proc Roy Soc 50:755, 1957. 2. Chany, C., et al: Severe and Fatal Pneumonia in Infants and Young Children Associated With Adenovirus Infections , Amer J Hyg 67:367, 1958. 3. Osada, R., and Hanayama, R.: A Fatal Case of Infantile Pneumonia Due to Adenovirus; Clinical Findings , Jap J Exp Med 28:293, 1958. 4. Deinhardt, F., et al: The Isolation of Adenovirus Type 1 From a Fatal Case of Viral "Pneumonitis," Arch Intern Med 102:816, 1958.Crossref 5. Dreizin, R.S., et al: Outbreaks of Adenovirus Infections , Prob Virol 5:196, 1960. 6. Parker, W.L.; Wilt, J.C.; and Stackiw, W.: Adenovirus Infections , Canad J Public Health 52:246, 1961. 7. Jen, K.F., et al: The Role of Adenovirus in the Etiology of Infantile Pneumonia and Pneumonia Complicating Measles , Chin Med J 81:141, 1962. 8. Benyesh-Melnick, M., and Rosenberg, H.S.: The Isolation of Adenovirus Type 7 From a Fatal Case of Pneumonia and Disseminated Disease , J Pediat 64:83, 1964.Crossref 9. Patzer, von H., and Braun, W.: Die Adenoviruspneumonie , Munchen Med Wschr 107:( (2) )1985, 1965. 10. Collier, A.M.; Connor, J.D.; and Irving, W.R.: Generalized Type 5 Adenovirus Infection Associated With the Pertussis Syndrome , J Pediat 69:1073, 1966.Crossref 11. Evans, A.S.: Latent Adenovirus Infections of the Human Respiratory Tract , Amer J Hyg 67:256, 1958. 12. Sohier, R.; Chardonnet, Y.; and Prunieras, M.: Adenoviruses: Status of Current Knowledge , Progr Med Virol 7:263, 1965. 13. Enders, J.: " Measles Virus ," in Lennette, E.H., and Schmidt, N.J. (eds.): Diagnostic Procedures for Viral and Rickettsial Diseases , New York: The American Public Health Association, Inc., 1964, p 534. 14. Boyer, G.S.; Leuchtenberger, C.; and Ginsberg, H.S.: Cytological and Cytochemical Studies of Hela Cells Infected With Adenoviruses , J Exp Med 105:192, 1957a.Crossref 15. Cabanel, G., et al: Acute Pericarditis With Reaction of Positive Complement Fixation to Adenoviruses , J Med Lyon 47:83, 1966. 16. Von Guthert, H.; Wockel, W.; and Meerbach, W.: Die adenoviruspneumonia: pathologische anatomie , Munchen Med Wschr 107( (2) ):1990, 1965. 17. Naib, Z.M., et al: Cytological Features of Viral Respiratory Tract Infections, Acta Cytologica, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Fatal Pneumonia Associated With Adenovirus Type 7

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1967.02090220042007
Publisher site
See Article on Publisher Site

Abstract

Abstract THE ASSOCIATION of adenoviruses with fatal disease in children has been noted in many parts of the world by several investigators.1-10 In view of the ability of this group of viruses to establish latent infection in various body tissues, including the lung,11 Sohier et al have recently proposed12 that even the recovery of these viruses from postmortem material is not definitive in establishing an etiological association with the patient's death. These workers would also require evidence of viral multiplication in affected organs. Such criteria have been fulfilled in the case we are presenting of a 10-month-old girl who died of severe pneumonia. Adenovirus type 7 was isolated not only from her stool, but also in high titer from her lungs and pericardial fluid. Histopathological changes consistent with adenovirus infection were observed in postmortem lung tissue. In addition, by the use of electron microscopy, viral particles morphologically consistent References 1. Pereira, H.G., and Kelly, B.: Studies on Natural and Experimental Infections by Adenovirus , Proc Roy Soc 50:755, 1957. 2. Chany, C., et al: Severe and Fatal Pneumonia in Infants and Young Children Associated With Adenovirus Infections , Amer J Hyg 67:367, 1958. 3. Osada, R., and Hanayama, R.: A Fatal Case of Infantile Pneumonia Due to Adenovirus; Clinical Findings , Jap J Exp Med 28:293, 1958. 4. Deinhardt, F., et al: The Isolation of Adenovirus Type 1 From a Fatal Case of Viral "Pneumonitis," Arch Intern Med 102:816, 1958.Crossref 5. Dreizin, R.S., et al: Outbreaks of Adenovirus Infections , Prob Virol 5:196, 1960. 6. Parker, W.L.; Wilt, J.C.; and Stackiw, W.: Adenovirus Infections , Canad J Public Health 52:246, 1961. 7. Jen, K.F., et al: The Role of Adenovirus in the Etiology of Infantile Pneumonia and Pneumonia Complicating Measles , Chin Med J 81:141, 1962. 8. Benyesh-Melnick, M., and Rosenberg, H.S.: The Isolation of Adenovirus Type 7 From a Fatal Case of Pneumonia and Disseminated Disease , J Pediat 64:83, 1964.Crossref 9. Patzer, von H., and Braun, W.: Die Adenoviruspneumonie , Munchen Med Wschr 107:( (2) )1985, 1965. 10. Collier, A.M.; Connor, J.D.; and Irving, W.R.: Generalized Type 5 Adenovirus Infection Associated With the Pertussis Syndrome , J Pediat 69:1073, 1966.Crossref 11. Evans, A.S.: Latent Adenovirus Infections of the Human Respiratory Tract , Amer J Hyg 67:256, 1958. 12. Sohier, R.; Chardonnet, Y.; and Prunieras, M.: Adenoviruses: Status of Current Knowledge , Progr Med Virol 7:263, 1965. 13. Enders, J.: " Measles Virus ," in Lennette, E.H., and Schmidt, N.J. (eds.): Diagnostic Procedures for Viral and Rickettsial Diseases , New York: The American Public Health Association, Inc., 1964, p 534. 14. Boyer, G.S.; Leuchtenberger, C.; and Ginsberg, H.S.: Cytological and Cytochemical Studies of Hela Cells Infected With Adenoviruses , J Exp Med 105:192, 1957a.Crossref 15. Cabanel, G., et al: Acute Pericarditis With Reaction of Positive Complement Fixation to Adenoviruses , J Med Lyon 47:83, 1966. 16. Von Guthert, H.; Wockel, W.; and Meerbach, W.: Die adenoviruspneumonia: pathologische anatomie , Munchen Med Wschr 107( (2) ):1990, 1965. 17. Naib, Z.M., et al: Cytological Features of Viral Respiratory Tract Infections, Acta Cytologica, to be published.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1967

References