Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Fatal Melanoma Arising in a Zosteriform Speckled Lentiginous Nevus

Fatal Melanoma Arising in a Zosteriform Speckled Lentiginous Nevus Abstract To the Editor.— The development of a cutaneous melanoma within a nevus spilus, or speckled lentiginous nevus, was recently reported in the Archives.1 A unique feature in that case was the presence histologically of intraepidermal melanocytic dysplasia within the "speckled" or hyperpigmented areas. The possibility that the melanocytic dysplasia was a predisposing factor for the development of the melanoma was considered. In the following case report, a melanoma developed within a zosteriform speckled lentiginous nevus that had histologic features that were similar to those described by Rhodes and Mihm.1 However, in contrast to previously reported cases,1-5 this patient subsequently developed metastatic disease that proved to be fatal. Report of a Case.— The patient was a 43-year-old white man with a history of a stage I cutaneous melanoma (Clark level III; Breslow depth, 1.6 mm) of the left posterior aspect of the neck diagnosed in 1986. His medical References 1. Rhodes A, Mihm MC Jr. Origin of cutaneous melanoma in a congenital dysplastic nevus spilus . Arch Dermatol. 1990;126:500-505.Crossref 2. Kopf AW, Levine LJ, Rigel DS, Friedman RJ, Levenstein M. Congenital-nevus-like-nevi, nevi spili, and café-au-lait spots in patients with malignant melanoma . J Dermatol Surg Oncol. 1985;11:275-280.Crossref 3. Vion B, Belaich S, Grossin M, Préaux J. Les aspects évolutifs du naevus sur naevus . Ann Dermatol Venereol. 1985;112:813-819. 4. Rhodes A. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes . In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austin KF, eds. Dermatology in General Medicine . 3rd ed. New York, NY: McGraw— Hill International Book Co; 1987;877-946. 5. Wagner RF, Cottel WI. In situ malignant melanoma arising in a speckled lentiginous nevus . J Am Acad Dermatol. 1989;20:125-126.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Fatal Melanoma Arising in a Zosteriform Speckled Lentiginous Nevus

Archives of Dermatology , Volume 127 (8) – Aug 1, 1991

Loading next page...
 
/lp/american-medical-association/fatal-melanoma-arising-in-a-zosteriform-speckled-lentiginous-nevus-rfq0Xz8wN1
Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680070142027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The development of a cutaneous melanoma within a nevus spilus, or speckled lentiginous nevus, was recently reported in the Archives.1 A unique feature in that case was the presence histologically of intraepidermal melanocytic dysplasia within the "speckled" or hyperpigmented areas. The possibility that the melanocytic dysplasia was a predisposing factor for the development of the melanoma was considered. In the following case report, a melanoma developed within a zosteriform speckled lentiginous nevus that had histologic features that were similar to those described by Rhodes and Mihm.1 However, in contrast to previously reported cases,1-5 this patient subsequently developed metastatic disease that proved to be fatal. Report of a Case.— The patient was a 43-year-old white man with a history of a stage I cutaneous melanoma (Clark level III; Breslow depth, 1.6 mm) of the left posterior aspect of the neck diagnosed in 1986. His medical References 1. Rhodes A, Mihm MC Jr. Origin of cutaneous melanoma in a congenital dysplastic nevus spilus . Arch Dermatol. 1990;126:500-505.Crossref 2. Kopf AW, Levine LJ, Rigel DS, Friedman RJ, Levenstein M. Congenital-nevus-like-nevi, nevi spili, and café-au-lait spots in patients with malignant melanoma . J Dermatol Surg Oncol. 1985;11:275-280.Crossref 3. Vion B, Belaich S, Grossin M, Préaux J. Les aspects évolutifs du naevus sur naevus . Ann Dermatol Venereol. 1985;112:813-819. 4. Rhodes A. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes . In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austin KF, eds. Dermatology in General Medicine . 3rd ed. New York, NY: McGraw— Hill International Book Co; 1987;877-946. 5. Wagner RF, Cottel WI. In situ malignant melanoma arising in a speckled lentiginous nevus . J Am Acad Dermatol. 1989;20:125-126.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1991

References