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Fatal Disseminated Cytomegalovirus Infection in an Apparently Normal Adult

Fatal Disseminated Cytomegalovirus Infection in an Apparently Normal Adult Abstract • An ostensibly normal 43-year-old man had intermittent fever, erythema multiforme, and leukopenia that evolved into fulminant hepatic and bone marrow necrosis. The cause of his illness was compatible with cytomegalovirus (CMV) infection since there was a fourfold increase in immunofluorescent antibody titer. This report suggests that CMV can produce a rapidly progressive and overwhelming infection in an apparently healthy adult. (Arch Intern Med 1983;143:372-373) References 1. Jordan MC, Rousseau WE, Stewart JA, et al: Spontaneous cytomegalovirus mononucleosis. Ann Intern Med 1973;79:153-160.Crossref 2. Stern H: Isolation of cytomegalovirus and clinical manifestations at different ages. Br Med J 1968;1:665-669.Crossref 3. Clark J, Craig RM, Saffro R, et al: Cytomegalovirus granulomatous hepatitis. Am J Med 1979;66:264-269.Crossref 4. Waris E, Räsänen O, Kreus K, et al: Fatal cytomegalovirus disease in a previously healthy adult. Scand J Infect Dis 1972;4:61-67. 5. Shusterman N, Frauenhoffer C, Kinsey MD: Fatal massive hepatic necrosis in cytomegalovirus mononucleosis. Ann Intern Med 1978;88:810-812.Crossref 6. Prescott LF, Wright N, Rosco P, et al: Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdose. Lancet 1971; 1:519-522.Crossref 7. Recknagle RO, Glende EA: Carbon tetrachloride hepatotoxicity: An example of lethal cleavage. CRC Crit Rev Toxicol 1973;2:263-297.Crossref 8. Henson DE, Grimley PM, Strauss AJ: Postnatal cytomegalovirus hepatitis. Hum Pathol 1974;5:93-103.Crossref 9. Hilty MD, Romshe CA, Delamaster PV: Reye's syndrome and hyperaminoacidemia. J Pediatr 1974;84:362-365.Crossref 10. Gottlieb MS, Schroff R, Schanker, HM, et al: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med 1981;305:1425-1431.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Fatal Disseminated Cytomegalovirus Infection in an Apparently Normal Adult

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020198039
Publisher site
See Article on Publisher Site

Abstract

Abstract • An ostensibly normal 43-year-old man had intermittent fever, erythema multiforme, and leukopenia that evolved into fulminant hepatic and bone marrow necrosis. The cause of his illness was compatible with cytomegalovirus (CMV) infection since there was a fourfold increase in immunofluorescent antibody titer. This report suggests that CMV can produce a rapidly progressive and overwhelming infection in an apparently healthy adult. (Arch Intern Med 1983;143:372-373) References 1. Jordan MC, Rousseau WE, Stewart JA, et al: Spontaneous cytomegalovirus mononucleosis. Ann Intern Med 1973;79:153-160.Crossref 2. Stern H: Isolation of cytomegalovirus and clinical manifestations at different ages. Br Med J 1968;1:665-669.Crossref 3. Clark J, Craig RM, Saffro R, et al: Cytomegalovirus granulomatous hepatitis. Am J Med 1979;66:264-269.Crossref 4. Waris E, Räsänen O, Kreus K, et al: Fatal cytomegalovirus disease in a previously healthy adult. Scand J Infect Dis 1972;4:61-67. 5. Shusterman N, Frauenhoffer C, Kinsey MD: Fatal massive hepatic necrosis in cytomegalovirus mononucleosis. Ann Intern Med 1978;88:810-812.Crossref 6. Prescott LF, Wright N, Rosco P, et al: Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdose. Lancet 1971; 1:519-522.Crossref 7. Recknagle RO, Glende EA: Carbon tetrachloride hepatotoxicity: An example of lethal cleavage. CRC Crit Rev Toxicol 1973;2:263-297.Crossref 8. Henson DE, Grimley PM, Strauss AJ: Postnatal cytomegalovirus hepatitis. Hum Pathol 1974;5:93-103.Crossref 9. Hilty MD, Romshe CA, Delamaster PV: Reye's syndrome and hyperaminoacidemia. J Pediatr 1974;84:362-365.Crossref 10. Gottlieb MS, Schroff R, Schanker, HM, et al: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med 1981;305:1425-1431.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References