Key PointsQuestionWhat is the family history rate and inheritance pattern of cluster headache? FindingsIn a systematic review of articles published between 1985 and 2016, which included 22 large cohort studies, cluster headache has a family history rate of 0% to 22%, with a median of 8.2%. A total of 67 pedigrees were identified, and the inheritance pattern of cluster headache was consistent with an autosomal dominant pattern in 69% of participants and an autosomal recessive pattern in 28%. MeaningPer this systematic review, cluster headache is an inherited disorder in a subset of patients, and the pattern of inheritance could be the result of multiple susceptibility genes as well as environmental factors.
JAMA Neurology – American Medical Association
Published: Jul 20, 2020
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