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Family History of Cluster Headache

Family History of Cluster Headache Key PointsQuestionWhat is the family history rate and inheritance pattern of cluster headache? FindingsIn a systematic review of articles published between 1985 and 2016, which included 22 large cohort studies, cluster headache has a family history rate of 0% to 22%, with a median of 8.2%. A total of 67 pedigrees were identified, and the inheritance pattern of cluster headache was consistent with an autosomal dominant pattern in 69% of participants and an autosomal recessive pattern in 28%. MeaningPer this systematic review, cluster headache is an inherited disorder in a subset of patients, and the pattern of inheritance could be the result of multiple susceptibility genes as well as environmental factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2020.0682
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the family history rate and inheritance pattern of cluster headache? FindingsIn a systematic review of articles published between 1985 and 2016, which included 22 large cohort studies, cluster headache has a family history rate of 0% to 22%, with a median of 8.2%. A total of 67 pedigrees were identified, and the inheritance pattern of cluster headache was consistent with an autosomal dominant pattern in 69% of participants and an autosomal recessive pattern in 28%. MeaningPer this systematic review, cluster headache is an inherited disorder in a subset of patients, and the pattern of inheritance could be the result of multiple susceptibility genes as well as environmental factors.

Journal

JAMA NeurologyAmerican Medical Association

Published: Jul 20, 2020

References