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Familial Occurrence of Drug-Induced Hearing Loss

Familial Occurrence of Drug-Induced Hearing Loss Abstract A sensorineural hearing loss was found in two members of a single family. Both mother and son had previously received streptomycin therapy. Although other causes of hearing loss in the son could not be eliminated, evidence is presented that supports streptomycin toxicity as the cause. To our knowledge, this represents the eighth such family in which a hearing loss secondary to streptomycin therapy has been described. It is believed that in these cases there is an increased sensitivity to this drug. References 1. Prazic M, Salaj B, Subotic R: Familial sensitivity to streptomycin . J Laryngol Otol 78:1037-1043, 1964.Crossref 2. Podvinec PS, Stefanovic P: Surdité par la streptomycine et prédisposition familiale , J Fr Otorhinolaryng 15:61-67, 1966. 3. Johnsonbaugh RE, et al: Audiometric study of streptomycin-treated infants . Am J Dis Child 112:43-45, 1966. 4. Robinson GC, Cambon KG: Hearing loss in infants of tuberculous mothers treated with streptomycin during pregnancy . N Engl J Med 271:949-951, 1964.Crossref 5. Varpela E, Hietalahti J, Aro MJT: Streptomycin and dihydrostreptomycin medication during pregnancy and their effect on the child's inner ear . Scand J Resp Dis 50:101-109, 1969. 6. Vuori M, Lahikainen EA, Peltonen T: Perceptive deafness in connection with mumps . Acta Otolaryngol 55:231-236, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Familial Occurrence of Drug-Induced Hearing Loss

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1974.02110210095014
Publisher site
See Article on Publisher Site

Abstract

Abstract A sensorineural hearing loss was found in two members of a single family. Both mother and son had previously received streptomycin therapy. Although other causes of hearing loss in the son could not be eliminated, evidence is presented that supports streptomycin toxicity as the cause. To our knowledge, this represents the eighth such family in which a hearing loss secondary to streptomycin therapy has been described. It is believed that in these cases there is an increased sensitivity to this drug. References 1. Prazic M, Salaj B, Subotic R: Familial sensitivity to streptomycin . J Laryngol Otol 78:1037-1043, 1964.Crossref 2. Podvinec PS, Stefanovic P: Surdité par la streptomycine et prédisposition familiale , J Fr Otorhinolaryng 15:61-67, 1966. 3. Johnsonbaugh RE, et al: Audiometric study of streptomycin-treated infants . Am J Dis Child 112:43-45, 1966. 4. Robinson GC, Cambon KG: Hearing loss in infants of tuberculous mothers treated with streptomycin during pregnancy . N Engl J Med 271:949-951, 1964.Crossref 5. Varpela E, Hietalahti J, Aro MJT: Streptomycin and dihydrostreptomycin medication during pregnancy and their effect on the child's inner ear . Scand J Resp Dis 50:101-109, 1969. 6. Vuori M, Lahikainen EA, Peltonen T: Perceptive deafness in connection with mumps . Acta Otolaryngol 55:231-236, 1962.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Feb 1, 1974

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