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Familial Corneal Hypesthesia

Familial Corneal Hypesthesia Abstract • A 4-year-old boy with severe, diffuse, asymptomatic, punctate, epithelial corneal erosions had bilateral sharply decreased corneal sensation with normal skin sensation in the distribution of the trigeminal nerves. Subsequent family studies disclosed five family members with similar corneal changes and decreased corneal sensation and no punctate erosions. None had decreased skin sensation in the distribution of the fifth cranial nerve. No environmental factors or evidence of local or systemic disease accounted for these findings. References 1. Hewsen GE: Congenital trigeminal anesthaesia . Br J Ophthalmol 47:308-311, 1963.Crossref 2. Anseth A: Congenital bilateral corneal anesthesia . Acta Ophthalmol 46:909-911, 1968.Crossref 3. Walsh FB, Hoyt WF: Clinical Neuroophthalmology . Baltimore, Williams & Wilkins Co, 1969, vol 1, pp 383-385, 1206. 4. Stewart HL, Wind CA, Kaufman, HE: Unilateral congenital corneal anesthesia . Am J Ophthalmol 74:334-335, 1972. 5. Lawford JB: Bilateral (congenital) anesthaesia of conjunctiva and cornea: Neuroparalytic keratitis . Trans Ophthalmol Soc UK 27:80, 1907. 6. Verrey A, Jequier M: Keratitis neuroparalytiques familiales . Bull Soc Fr Ophtalmol 62:171-177, 1949. 7. Schenk H: Hornhautbefunde bei idiopathischer Anästhesie der Hornhaut . Klin Monatsbl Augenheilkd 133:506-518, 1958. 8. Carpel EF: Congenital corneal anesthesia . Am J Ophthalmol 85:357-359, 1978. 9. Riley CM, Moore RH: Familial dysautonomia differentiated from related disorders: Case reports and discussion of current concepts . Pediatrics 37:435-446, 1966. 10. Bowen R: Hereditary ectodermal dysplasia of the anhidrotic type . South Med J 50:1018-1021, 1957.Crossref 11. Ford FK, Wilkins L: Congenital universal insensitivity to pain . Bull J Hopkins Hosp 62:448-466, 1938. 12. MoHandessan MM, Romano PE: Neuroparalytic keratitis in Goldenhar-Gorlin syndrome . Am J Ophthalmol 85:111-113, 1978. 13. Shields JA, Waring GO, Monte LG: Ocular findings in leprosy . Am J Ophthalmol 77:880-890, 1974. 14. Schirmer KE, Mellor LD: Corneal sensitivity after cataract extraction . Arch Ophthalmol 65:433-436, 1961.Crossref 15. Goldberg MF: Genetic and Metabolic Eye Disease . Boston, Little Brown & Co, 1974, pp 281-323. 16. Schwartz DE: Corneal sensitivity in diabetes . Arch Ophthalmol 91:174-178, 1974.Crossref 17. McDonald R: Carbon disulfide poisoning . Arch Ophthalmol 20:839-845, 1938.Crossref 18. Sjögren H: A contribution to our knowledge of the ocular changes induced by sulphurated hydrogen . Acta Ophthalmol 17:166-171, 1939.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1979.01020010430005
Publisher site
See Article on Publisher Site

Abstract

Abstract • A 4-year-old boy with severe, diffuse, asymptomatic, punctate, epithelial corneal erosions had bilateral sharply decreased corneal sensation with normal skin sensation in the distribution of the trigeminal nerves. Subsequent family studies disclosed five family members with similar corneal changes and decreased corneal sensation and no punctate erosions. None had decreased skin sensation in the distribution of the fifth cranial nerve. No environmental factors or evidence of local or systemic disease accounted for these findings. References 1. Hewsen GE: Congenital trigeminal anesthaesia . Br J Ophthalmol 47:308-311, 1963.Crossref 2. Anseth A: Congenital bilateral corneal anesthesia . Acta Ophthalmol 46:909-911, 1968.Crossref 3. Walsh FB, Hoyt WF: Clinical Neuroophthalmology . Baltimore, Williams & Wilkins Co, 1969, vol 1, pp 383-385, 1206. 4. Stewart HL, Wind CA, Kaufman, HE: Unilateral congenital corneal anesthesia . Am J Ophthalmol 74:334-335, 1972. 5. Lawford JB: Bilateral (congenital) anesthaesia of conjunctiva and cornea: Neuroparalytic keratitis . Trans Ophthalmol Soc UK 27:80, 1907. 6. Verrey A, Jequier M: Keratitis neuroparalytiques familiales . Bull Soc Fr Ophtalmol 62:171-177, 1949. 7. Schenk H: Hornhautbefunde bei idiopathischer Anästhesie der Hornhaut . Klin Monatsbl Augenheilkd 133:506-518, 1958. 8. Carpel EF: Congenital corneal anesthesia . Am J Ophthalmol 85:357-359, 1978. 9. Riley CM, Moore RH: Familial dysautonomia differentiated from related disorders: Case reports and discussion of current concepts . Pediatrics 37:435-446, 1966. 10. Bowen R: Hereditary ectodermal dysplasia of the anhidrotic type . South Med J 50:1018-1021, 1957.Crossref 11. Ford FK, Wilkins L: Congenital universal insensitivity to pain . Bull J Hopkins Hosp 62:448-466, 1938. 12. MoHandessan MM, Romano PE: Neuroparalytic keratitis in Goldenhar-Gorlin syndrome . Am J Ophthalmol 85:111-113, 1978. 13. Shields JA, Waring GO, Monte LG: Ocular findings in leprosy . Am J Ophthalmol 77:880-890, 1974. 14. Schirmer KE, Mellor LD: Corneal sensitivity after cataract extraction . Arch Ophthalmol 65:433-436, 1961.Crossref 15. Goldberg MF: Genetic and Metabolic Eye Disease . Boston, Little Brown & Co, 1974, pp 281-323. 16. Schwartz DE: Corneal sensitivity in diabetes . Arch Ophthalmol 91:174-178, 1974.Crossref 17. McDonald R: Carbon disulfide poisoning . Arch Ophthalmol 20:839-845, 1938.Crossref 18. Sjögren H: A contribution to our knowledge of the ocular changes induced by sulphurated hydrogen . Acta Ophthalmol 17:166-171, 1939.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1979

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