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H. Eagle (1941)
On the Specificity of Serologic Tests for Syphilis as Determined by 40,545 Tests in a College-Student Population.American Journal of Syphilis, 25
S. Epstein (1979)
Limitations of electrocardiographic exercise testing.The New England journal of medicine, 301 5
E. Garson (1959)
Recent developments in the laboratory diagnosis of syphilis.Annals of internal medicine, 51
R. Jones (1979)
Bayes' theorem, the exercise ECG, and coronary artery disease.JAMA, 242 10
ALMOST simultaneously two important journals have called editorial attention to the limitations of the stress ECG in the diagnosis of coronary artery disease.1,2 It is said that there are excessive numbers of false-positive tests in patients at low risk of disease and false-negatives in those at high risk. Both discussions invoke a concept from probability theory known as Bayes' theorem, which one writer explicitly advises the clinician to master. False-positive Tests for Syphilis The issue is reminiscent of what was called "the false-positive problem" in syphilis about which much was written 30 years ago. This article briefly reviews that subject, a matter of historic interest, since the Wassermann test and its modifications were the first important tests acknowledged to possess an inherent tendency to false reactivity. It also furnishes an instructive example of the connection between the value of a test and the prevalence of the disease sought, which
JAMA – American Medical Association
Published: Jun 13, 1980
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