Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Failure of Oral Inosiplex Treatment of Recurrent Herpes Simplex Virus Infections

Failure of Oral Inosiplex Treatment of Recurrent Herpes Simplex Virus Infections Abstract • A compound, a mixture of acedoben, dimepranol, and inosine (inosiplex) was used to treat recurrent local herpes simplex virus (HSV) infections in a double-blind placebo-controlled crossover study. Altogether, 58 patients with a history of frequently recurrent HSV infections were examined. Eighteen selected patients participated in the drug trial. Ten patients received both inosiplex and placebo, three received only inosiplex, and five received only the placebo. Three patients received both placebo and inosiplex twice. No substantial differences between the treatments with inosiplex or placebo could be seen in the frequency of occurrence or healing of the local lesions, nor in the results of these patients' immunologic studies. An evident placebo effect was observed, since only 15 (26%) of the 58 subjects examined continued to have an often relapsing form of the disease when followed up regularly. (Arch Dermatol 1983;119:463-467) References 1. Curry SS: Cutaneous herpes simplex infections and their treatment . Cutis 1980;26:41-58. 2. Jarrat M, Smith R, Knox JM: Therapy of herpes simplex infection . Int J Dermatol 1979;18:357-361. 3. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy proved herpes simplex encephalitis . N Engl J Med 1977;297:289-294.Crossref 4. Muldoon RL, Mezny L, Jackson GG: Effect of isoprinosine against influenza and some other viruses causing respiratory diseases . Antimicrob Agents Chemother 1972;2:224-228.Crossref 5. Simon ZN, Glasky AJ: Isoprinosine: An overview . Cancer Treat Rep 1978;62:1963-1969. 6. Wicket WH Jr, Bradshaw JL: Clinical effectiveness of the immunopotentiating agent inosiplex in herpes virus infections, abstracted . Am Soc Microbiol 1976; p 78. 7. Bradshaw LJ, Sumner HL: In vitro studies on cell-mediated immunity in patients treated with inosiplex for herpes simplex virus infection . Ann NY Acad Sci 1977;284:190-196.Crossref 8. Chang TW, Weinstein L: Antiviral activity of isoprinosine in vivo and in vitro . Am J Med Sci 1973;265:143-148.Crossref 9. Hadden JW, Hadden EM, Coffey RG: Isoprinosine augmentation of phytohemagglutinin induced lymphocyte proliferation . Infect Immun 1976;13:382-387. 10. Böyum A: A one-stage procedure for isolation of granulocytes and lymphocytes for human blood . Scand J Clin Lab Invest 1968;97( (suppl 21) ):51-76. 11. Kalimo K, Joronen I, Havu V: Cell-mediated immunity against herpes simplex virus envelope, capsid, excreted and crude antigens . Infect Immun , in press. 12. Wybran J, Carr MC, Fudenberg HH: Effect of serum on human rosette forming cells in fetuses and adult blood . Clin Immunol Immunopathol 1973;1:408-413.Crossref 13. Pettersson D, Mellstedt H, Holm H: IgG on human blood lymphocytes studied by immunofluorescence . Scand J Immunol 1978;8:535-538.Crossref 14. Kalimo KOK, Marttila RJ, Granfors K, et al: Solid-phase radioimmunoassay of human immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope and excreted antigens . Infect Immun 1977;15:883-889. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Failure of Oral Inosiplex Treatment of Recurrent Herpes Simplex Virus Infections

Loading next page...
 
/lp/american-medical-association/failure-of-oral-inosiplex-treatment-of-recurrent-herpes-simplex-virus-ye09gcMt03
Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650300017008
Publisher site
See Article on Publisher Site

Abstract

Abstract • A compound, a mixture of acedoben, dimepranol, and inosine (inosiplex) was used to treat recurrent local herpes simplex virus (HSV) infections in a double-blind placebo-controlled crossover study. Altogether, 58 patients with a history of frequently recurrent HSV infections were examined. Eighteen selected patients participated in the drug trial. Ten patients received both inosiplex and placebo, three received only inosiplex, and five received only the placebo. Three patients received both placebo and inosiplex twice. No substantial differences between the treatments with inosiplex or placebo could be seen in the frequency of occurrence or healing of the local lesions, nor in the results of these patients' immunologic studies. An evident placebo effect was observed, since only 15 (26%) of the 58 subjects examined continued to have an often relapsing form of the disease when followed up regularly. (Arch Dermatol 1983;119:463-467) References 1. Curry SS: Cutaneous herpes simplex infections and their treatment . Cutis 1980;26:41-58. 2. Jarrat M, Smith R, Knox JM: Therapy of herpes simplex infection . Int J Dermatol 1979;18:357-361. 3. Whitley RJ, Soong SJ, Dolin R, et al: Adenine arabinoside therapy of biopsy proved herpes simplex encephalitis . N Engl J Med 1977;297:289-294.Crossref 4. Muldoon RL, Mezny L, Jackson GG: Effect of isoprinosine against influenza and some other viruses causing respiratory diseases . Antimicrob Agents Chemother 1972;2:224-228.Crossref 5. Simon ZN, Glasky AJ: Isoprinosine: An overview . Cancer Treat Rep 1978;62:1963-1969. 6. Wicket WH Jr, Bradshaw JL: Clinical effectiveness of the immunopotentiating agent inosiplex in herpes virus infections, abstracted . Am Soc Microbiol 1976; p 78. 7. Bradshaw LJ, Sumner HL: In vitro studies on cell-mediated immunity in patients treated with inosiplex for herpes simplex virus infection . Ann NY Acad Sci 1977;284:190-196.Crossref 8. Chang TW, Weinstein L: Antiviral activity of isoprinosine in vivo and in vitro . Am J Med Sci 1973;265:143-148.Crossref 9. Hadden JW, Hadden EM, Coffey RG: Isoprinosine augmentation of phytohemagglutinin induced lymphocyte proliferation . Infect Immun 1976;13:382-387. 10. Böyum A: A one-stage procedure for isolation of granulocytes and lymphocytes for human blood . Scand J Clin Lab Invest 1968;97( (suppl 21) ):51-76. 11. Kalimo K, Joronen I, Havu V: Cell-mediated immunity against herpes simplex virus envelope, capsid, excreted and crude antigens . Infect Immun , in press. 12. Wybran J, Carr MC, Fudenberg HH: Effect of serum on human rosette forming cells in fetuses and adult blood . Clin Immunol Immunopathol 1973;1:408-413.Crossref 13. Pettersson D, Mellstedt H, Holm H: IgG on human blood lymphocytes studied by immunofluorescence . Scand J Immunol 1978;8:535-538.Crossref 14. Kalimo KOK, Marttila RJ, Granfors K, et al: Solid-phase radioimmunoassay of human immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope and excreted antigens . Infect Immun 1977;15:883-889.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1983

References