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Failure of Griseofulvin to Control Experimental Systemic Mycoses in Mice

Failure of Griseofulvin to Control Experimental Systemic Mycoses in Mice Abstract Introduction Since Gentles' discovery1 that griseofulvin, an antibiotic isolated from Penicillium griseofulvum and studied 19 years before,2 was effective in shortening the severity and duration of experimental dermatophytosis in guinea pigs, this therapeutic agent has had remarkably prompt, thorough, and eminently successful clinical trials. It is an ideal specific treatment for dermatophytosis because it is nontoxic at therapeutic doses, is administered orally, and it accumulates in fungistatic concentrations in the keratinized tissues which are attacked by the dermatophytes.3 Although griseofulvin is less active in vitro against the fungi which cause systemic mycoses than against the dermatophytes, tests of its therapeutic effect upon experimental systemic mycoses were obviously indicated. Materials and Methods General purpose, female, Swiss, white mice weighing 17-20 gm. were infected by injection into a tail vein of cell or spore suspensions of fungi, using the type of mouse holder designed by Feber4 in this References 1. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature 182:476-477, 1958.Crossref 2. Oxford, A. E.; Raistrick, H., and Simonart, P.: Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin C17H17O6Cl, a Metabolic Product of Penicillium Griseofulvum Dierckx , Biochem. J. 33:240-248, 1939. 3. Blank, H., and Roth, F. J., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259-266, 1959.Crossref 4. Feder, N.: A Method of Holding Mice for Intravenous Injection , J. Lab. & Clin. Med. 51: 662-663 ( (April) ) 1958. 5. Emmons, C. W., and Ashburn, L. L.: Histoplasmosis in Wild Rats: Occurrence and Histopathology , Public Health Rep. 63:1416-1422, 1948. 6. Latapi, F.; Lavalle, P.; Novales, J., and Ortiz, Y.: Griseofulvina en micosis cutaneas profundas , Dermatologia (Méx.) 3:34-41, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Failure of Griseofulvin to Control Experimental Systemic Mycoses in Mice

A.M.A. Archives of Dermatology , Volume 81 (5) – May 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730050056010
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Since Gentles' discovery1 that griseofulvin, an antibiotic isolated from Penicillium griseofulvum and studied 19 years before,2 was effective in shortening the severity and duration of experimental dermatophytosis in guinea pigs, this therapeutic agent has had remarkably prompt, thorough, and eminently successful clinical trials. It is an ideal specific treatment for dermatophytosis because it is nontoxic at therapeutic doses, is administered orally, and it accumulates in fungistatic concentrations in the keratinized tissues which are attacked by the dermatophytes.3 Although griseofulvin is less active in vitro against the fungi which cause systemic mycoses than against the dermatophytes, tests of its therapeutic effect upon experimental systemic mycoses were obviously indicated. Materials and Methods General purpose, female, Swiss, white mice weighing 17-20 gm. were infected by injection into a tail vein of cell or spore suspensions of fungi, using the type of mouse holder designed by Feber4 in this References 1. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature 182:476-477, 1958.Crossref 2. Oxford, A. E.; Raistrick, H., and Simonart, P.: Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin C17H17O6Cl, a Metabolic Product of Penicillium Griseofulvum Dierckx , Biochem. J. 33:240-248, 1939. 3. Blank, H., and Roth, F. J., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259-266, 1959.Crossref 4. Feder, N.: A Method of Holding Mice for Intravenous Injection , J. Lab. & Clin. Med. 51: 662-663 ( (April) ) 1958. 5. Emmons, C. W., and Ashburn, L. L.: Histoplasmosis in Wild Rats: Occurrence and Histopathology , Public Health Rep. 63:1416-1422, 1948. 6. Latapi, F.; Lavalle, P.; Novales, J., and Ortiz, Y.: Griseofulvina en micosis cutaneas profundas , Dermatologia (Méx.) 3:34-41, 1959.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1960

References