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Failure of Clinical Dextran to Prevent Infusion Phlebitis

Failure of Clinical Dextran to Prevent Infusion Phlebitis Abstract Alternate intravenously administered infusions in 127 surgical patients had 500 ml of clinical dextran 75 added per day. The degree of phlebitis at the site of infusion was evaluated at the time of its discontinuation. The incidence of infusion phlebitis was found to be 30% in both treated and control groups, volume and duration of infusion being comparable. These results are discussed in relation to the value of dextran in the prevention and treatment of thrombophlebitis. References 1. Sawyer RB, Moncrief JA, Canizaro PC: Dextran therapy in thrombophlebitis . JAMA 191:740-742, 1965.Crossref 2. Ernst CB, Fry WJ, Kraft RO, et al: The role of low molecular weight dextran in the management of venous thrombosis . Surg Gynec Obstet 119:1243-1247, 1964. 3. Cox EF, Flotte CT, Buxton RW: Dextran in the treatment of thrombophlebitis . Surgery 57:225-229, 1965. 4. Gray TC: Annual meeting of the Royal College of Surgeons . Brit Med J 1:107, 1967.Crossref 5. Vere DW, Sykes CH, Armitage P: Venous thrombosis during dextrose infusion . 2:627-630, 1966. 6. Elfving G, Silvonen E, Tammisto T: Letter in correspondence . Lancet 2:226, 1966.Crossref 7. Fonkalsrud EW, Pederson BM, Murphy J, et al: Reduction of infusion thrombophlebitis with buffered glucose solutions . Surgery 63:280-284, 1968. 8. Elfving G, Saikku K: Effect of pH on the incidence of infusion thrombophlebitis . Lancet 1:953, 1966.Crossref 9. Jones PF: Thrombophlebitis following intravenous infusions . Postgrad Med J 33:444-447, 1957.Crossref 10. Just-Viera JE, Yeager GH: Protection from thrombosis in large veins . Surg Gynec Obstet 118:354-360, 1964. 11. Moncrief JA, Darin JC, Canizaro PC, et al: Use of dextran to prevent arterial and venous thrombosis . Ann Surg 158:553-560, 1963.Crossref 12. Johnson DC, Reeve TS: The effect and clinical significance of low molecular weight and clinical dextran on an experimental venous thrombus in sheep . Ann Surg 168:123-127, 1968.Crossref 13. Pelner L, Vamvas G: Phlegmasia cerulea dolens . JAMA 196:913-915, 1966.Crossref 14. Levy JS, Trippel OH, Bergan JJ: Successful use of dextran in phlegmasia cerulea dolens . Arch Surg 93:33-39, 1966.Crossref 15. Bennett PN, Dhall DP, McKenzie FN, et al: Effects of dextran infusion on the adhesiveness of human blood-platelets . Lancet 2:1001-1003, 1966.Crossref 16. Putnam TC, Kevy SV, Replogle RL: Factors influencing the viscosity of blood . Surg Gynec Obstet 124:547-552, 1967. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Failure of Clinical Dextran to Prevent Infusion Phlebitis

Archives of Surgery , Volume 101 (4) – Oct 1, 1970

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1970.01340280068017
Publisher site
See Article on Publisher Site

Abstract

Abstract Alternate intravenously administered infusions in 127 surgical patients had 500 ml of clinical dextran 75 added per day. The degree of phlebitis at the site of infusion was evaluated at the time of its discontinuation. The incidence of infusion phlebitis was found to be 30% in both treated and control groups, volume and duration of infusion being comparable. These results are discussed in relation to the value of dextran in the prevention and treatment of thrombophlebitis. References 1. Sawyer RB, Moncrief JA, Canizaro PC: Dextran therapy in thrombophlebitis . JAMA 191:740-742, 1965.Crossref 2. Ernst CB, Fry WJ, Kraft RO, et al: The role of low molecular weight dextran in the management of venous thrombosis . Surg Gynec Obstet 119:1243-1247, 1964. 3. Cox EF, Flotte CT, Buxton RW: Dextran in the treatment of thrombophlebitis . Surgery 57:225-229, 1965. 4. Gray TC: Annual meeting of the Royal College of Surgeons . Brit Med J 1:107, 1967.Crossref 5. Vere DW, Sykes CH, Armitage P: Venous thrombosis during dextrose infusion . 2:627-630, 1966. 6. Elfving G, Silvonen E, Tammisto T: Letter in correspondence . Lancet 2:226, 1966.Crossref 7. Fonkalsrud EW, Pederson BM, Murphy J, et al: Reduction of infusion thrombophlebitis with buffered glucose solutions . Surgery 63:280-284, 1968. 8. Elfving G, Saikku K: Effect of pH on the incidence of infusion thrombophlebitis . Lancet 1:953, 1966.Crossref 9. Jones PF: Thrombophlebitis following intravenous infusions . Postgrad Med J 33:444-447, 1957.Crossref 10. Just-Viera JE, Yeager GH: Protection from thrombosis in large veins . Surg Gynec Obstet 118:354-360, 1964. 11. Moncrief JA, Darin JC, Canizaro PC, et al: Use of dextran to prevent arterial and venous thrombosis . Ann Surg 158:553-560, 1963.Crossref 12. Johnson DC, Reeve TS: The effect and clinical significance of low molecular weight and clinical dextran on an experimental venous thrombus in sheep . Ann Surg 168:123-127, 1968.Crossref 13. Pelner L, Vamvas G: Phlegmasia cerulea dolens . JAMA 196:913-915, 1966.Crossref 14. Levy JS, Trippel OH, Bergan JJ: Successful use of dextran in phlegmasia cerulea dolens . Arch Surg 93:33-39, 1966.Crossref 15. Bennett PN, Dhall DP, McKenzie FN, et al: Effects of dextran infusion on the adhesiveness of human blood-platelets . Lancet 2:1001-1003, 1966.Crossref 16. Putnam TC, Kevy SV, Replogle RL: Factors influencing the viscosity of blood . Surg Gynec Obstet 124:547-552, 1967.

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1970

References