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W. Boothby (1935)
MYASTHENIA GRAVIS: (SIXTH REPORT)Annals of Internal Medicine, 9
M. Harris, E. Brand (1933)
METABOLIC AND THERAPEUTIC STUDIES IN THE MYOPATHIES: WITH SPECIAL REFERENCE TO GLYCINE ADMINISTRATIONJAMA, 101
W. Rose (1933)
The Metabolism of Creatine and CreatinineAnnual Review of Biochemistry, 2
A. Chaikelis (1941)
THE EFFECT OF GLYCOCOLL (GLYCINE) INGESTION UPON THE GROWTH, STRENGTH AND CREATININE-CREATINE EXCRETION IN MANAmerican Journal of Physiology, 132
K. Bloch, R. Schoenheimer, D. Rittenberg (1941)
Bate of formation and disappearance of body creatine in normal animals.Journal of Biological Chemistry, 138
W. Boothby (1934)
MYASTHENIA GRAVIS: THE EFFECT OF TREATMENT WITH GLYCINE AND EPHEDRINE; THIRD REPORTJAMA Internal Medicine, 53
P. Karpovich, K. Pestrecov (1941)
EFFECT OF GELATIN UPON MUSCULAR WORK IN MANAmerican Journal of Physiology, 134
R. Kaczmarek (1940)
Effect of Gelatin on the Work Output of Male Athletes and Non-Athletes and Girl SubjectsResearch Quarterly. American Association for Health, Physical Education and Recreation, 11
S. Robinson, P. Harmon (1941)
The effects of training and of gelatin upon certain factors which limit muscular work.American Journal of Physiology, 133
K. Bloch, R. Schoenheimer (1941)
THE BIOLOGICAL PRECURSORS OF CREATINEJournal of Biological Chemistry, 138
F. Hellebrandt, Rozelle Rork, Elizabeth Brogdon (1940)
Effect of Gelatin on Power of Women to Perform Maximal Anaerobic Work.∗Proceedings of the Society for Experimental Biology and Medicine, 43
G. Maison (1940)
FAILURE OF GELATIN OR AMINO-ACETIC ACID TO INCREASE THE WORK ABILITY: OF INDIVIDUAL NORMAL HUMAN MUSCLESJAMA, 115
N. Weissman, R. Schoenheimer (1941)
THE RELATIVE STABILITY OF l(+)-LYSINE IN RATS STUDIED WITH DEUTERIUM AND HEAVY NITROGENJournal of Biological Chemistry, 140
R. Fisher, A. Wilhelmi (1940)
OBSERVATIONS ON THE RELATION OF UREA AND GLYCINE TO CREATINE SYNTHESISJournal of Biological Chemistry, 132
C. Schmidt, C. Thomas (1939)
The Chemistry of the Amino Acids and ProteinsSoil Science, 47
A. Quick (1931)
The conjugation of benzoic acid in man.Journal of Biological Chemistry, 92
During the past decade aminoacetic acid has been used in the treatment of various myopathies and currently is the subject of debate relative to its value in the treatment of fatigue and in increasing endurance. Aminoacetic acid is also known as glycine and glycocoll. It is present in most of the common proteins, and by chemical analyses1 one fourth of the protein, gelatin, has been shown to be aminoacetic acid. From 1927 to 1929 Brand, Harris, Sandberg and Ringer2 in their search for the precursor of creatine first gave aminoacetic acid to patients with progressive muscular dystrophy. Thomas, Milhorat and Techner3 in 1932 reported clinical improvement in certain patients with this disease after prolonged treatment with this amino acid. Brand and his co-workers4 in their original work, and later in 1933, and Boothby5 in 1934 failed to find such beneficial effect in patients with progressive
JAMA – American Medical Association
Published: Feb 21, 1942
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