Abstract During the period of the last 7 or 8 years, in which operations on the aorta and its branches for atherosclerotic disease have been used extensively, it has been observed repeatedly that atheromatous material tends to be deposited in greatest concentration in the posterior wall of the abdominal aorta and common iliac arteries and at the orifices of branch vessels. The experimental work of Hass, Taylor, and their associates4,8 has suggested the importance of physical factors in atherogenesis. It has occurred to us that anatomical factors which mechanically fix the abdominal aorta and the iliacs to the vertebral column and the bony pelvis may be instrumental in determining these sites of atheromatous predilection by restriction of the amplitude of pulsation of the dorsal arterial wall, impairment of capillary, or lymphatic drainage of lipid material from the area or by some other mechanism. Some degree of mechanical fixation of a References 1. Dr. George Elliott, Assistant Professor of Comparative Pathology, Vanderbilt University School of Medicine. 2. Clatworthy, H. W., Jr.; Sako, Y.; Chisholm, T. C.; Culmer, C., and Varco, R. L.: Thoracic Aortic Coarctation , Surgery 28:245, 1950. 3. Creech, O., Jr.; Jordan, G. L., Jr.; DeBakey, M. E.; Overton, R. C., and Halpert, B.: The Effect of Chronic Hypercholesterolemia on Canine Aortic Transplants , Surg. Gynec. Obstet. 101:607, 1955. 4. Fillios, L. C.; Andrus, S. B.; Mann, G. V., and Stare, F. J.: Experimental Production of Gross Atherosclerosis in the Rat , J. Exp. Med. 104:539, 1956.Crossref 5. Kelly, F. B., Jr., Taylor, C. B., and Hass, G. M.: Experimental Atheroarteriosclerosis: Localization of Lipids in Experimental Lesions of Rabbits with Hypercholesteremia , Arch. Path. 53:419, 1952. 6. Page, I. H., and Brown, H. B.: Induced Hypercholesterolemia and Atherogenesis , Circulation 6:681, 1952.Crossref 7. Sako, Y.: The Effect of Hypertension on Experimental Atherosclerosis , Surg. Forum 11:176, 1960. 8. Steiner, A., and Kendall, F. E.: Atherosclerosis and Arteriosclerosis in Dogs Following Ingestion of Cholesterol and Thiouracil , Arch. Path. 42:433, 1946. 9. Taylor, C. B.: The Reaction of Arteries to Injury by Physical Agents: Symposium on Atherosclerosis , Washington, National Academy of Sciences, National Research Council, 1954, pp. 74-90.
Archives of Surgery – American Medical Association
Published: Jan 1, 1962