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H. R. Butt , W. H. Leake, R. F. Solley, G. C. Griffith, R. W. Huntington (1945)
Studies in Rheumatic Fever: I. The Physiologic Effect of Sodium Salicylate on the Human Being with Particular Reference to the Prothrombin Level of the Blood and the Effect on Hepatic ParenchymaJ. A. M. A., 128
H. Neivert , L. A. Pirk (1946)
Late Secondary Tonsillar HemorrhageArch. Otolaryng., 43
G. Livingston, E. Neary (1948)
The question of prothrombinopenic hemorrhage from post-tonsillectomy use of chewing gum containing acetylsalicylic acid.Archives of otolaryngology, 47 1
S. Fox, G. West (1947)
Vitamin k and late tonsillar hemorrhageThe Laryngoscope, 57
R. Kark (1941)
Hypoprothrombinemia and Avitaminosis K in ManBrit. M. J., 2
C. Higley (1945)
Use of salicylates in rheumatic fever; mixture of aspirin and vitamin K unwarranted.Journal of the American Medical Association, 129
S. Rapoport, M. Wing, G. Guest (1943)
Hypoprothrombinemia After Salicylate Administration in Man and RabbitsProceedings of the Society for Experimental Biology and Medicine, 53
S. L. Fox (1948)
Vitamins and Late Tonsillar HemorrhageBull. School Med. Univ. Maryland, 32
M. Ersner, D. Myers, William Ersner (1934)
X. A Clinical and Experimental Study of the Action of Saliva on Blood Coagulation and Wound Healing in Surgery of the Oral Cavity and ThroatAnnals of Otology, Rhinology & Laryngology, 43
C. S. Higley (1945)
Use of Salicylates in Rheumatic Fever?Mixture of Aspirin and Vitamin K UnwarrantedJ. A. M. A., 129
A. Coombs (1950)
A study of delayed bleeding following removal of the tonsils and adenoids.The Laryngoscope, 60
R. Overman, J. Field, C. Baumann, K. Link (1942)
Studies on the Hemorrhagic Sweet Clover Disease IX. The Effect of Diet and Vitamin K on the Hypopro-Thrombinemia Induced by 3,3???-Methylenebis (4-Hydroxycoumarin) in the RatOne FigureJournal of Nutrition, 23
K. Link, R. Overman, W. Sullivan, C. Huebner, L. Scheel (1943)
STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE XI. HYPOPROTHROMBINEMIA IN THE RAT INDUCED BY SALICYLIC ACIDJournal of Biological Chemistry, 147
R. Singer (1945)
Acetylsalicylic Acid: A Probable Cause for Secondary Post-Tonsillectomy HemorrhageArch. Otolaryng., 42
S. Shapiro , M. H. Redish (1943)
Studies on Prothrombin in ManProc. Soc. Exper. Biol. & Med., 53
O. Meyer, B. Howard (1943)
Production of Hypoprothrombinemia and Hypoeoagulability of the Blood with Salicylates.∗Proceedings of the Society for Experimental Biology and Medicine, 53
F. S. Coombs , H. A. Warren (1945)
Toxicity of SalicylatesJ. Lab. & Clin. Med., 30
H. Preston (1949)
Postoperative tonsil bleeding. Studies of the etiology, prevention and managementThe Laryngoscope, 59
H. Butt, W. Leake, R. Solley, G. Griffith, R. Huntington, H. Montgomery (1945)
STUDIES IN RHEUMATIC FEVER: THE PHYSIOLOGIC EFFECT OF SODIUM SALICYLATE ON THE HUMAN BEING, WITH PARTICULAR REFERENCE TO THE PROTHROMBIN LEVEL OF THE BLOOD AND THE EFFECT ON HEPATIC PARENCHYMAJAMA, 128
K. P. Link , R. S. Overman, W. R. Sullivan, C. F. Huebner (1943)
Studies on the Hemorrhagic Sweet Clover DiseaseJ. Biol. Chem., 147
V. P. Fishman (1947)
Post-Tonsillectomy HemorrhageBull. Pract. Ophth., 17
A. Quick (1944)
SALICYLATES AND HEMORRHAGEJAMA, 126
Abstract LATE SECONDARY hemorrhage following tonsilloadenoidectomy is an important question to the otolaryngologist. In the last decade it has been the subject of much investigation. Possible factors are acetylsalicylic acid intake, vitamin K and D deficiencies, excessive surgical trauma, infection, menstruation, abnormally large blood supply, liver disease, syphilis, pregnancy and blood dyscrasias. Of these, postoperative use of acetylsalicylic acid has been suspected of being the commonest cause. The ground work for this suspicion was laid by Link and associates,1 Rapoport and associates,2 Meyer and and Howard,3 Shapiro and associates4 and others who showed that a hypoprothrombinemia could be induced in animals and man by oral or intravenous administration of salicylates. This effect could be prevented or cured by vitamin K. Later Neivert5 corroborated these laboratory findings and suggested that this effect might be an important cause of late secondary bleeding after tonsillectomy. He reported that a References 1. Link, K. P.; Overman, R. S.; Sullivan, W. R.; Huebner, C. F., and Scheel, L. D.: Studies on the Hemorrhagic Sweet Clover Disease , J. Biol. Chem. 147:463 ( (Feb.) ) 1943. 2. Rapoport, S.; Wing, M., and Guest, G. M.: Hypoprothrombinemia After Salicylate Administration in Man and Rabbit , Proc. Soc. Exper. Biol. & Med. 53:40 ( (May) ) 1943. 3. Meyer, O. O., and Howard, B.: Production of Hypoprothrombinemia and Hypocoagulability of the Blood with Salicylates , Proc. Soc. Exper. Biol. & Med. 53:234 ( (June) ) 1943. 4. Shapiro, S.; Redish, M. H., and Campbell, H. A.: Studies on Prothrombin in Man , Proc. Soc. Exper. Biol. & Med. 53:251 ( (June) ) 1943. 5. Neivert, H.: Late Secondary Tonsillar Hemorrhage , Arch. Otolaryng. 42:14 ( (July) ) 1945. 6. Singer, R.: Acetylsalicylic Acid: A Probable Cause for Secondary Post-Tonsillectomy Hemorrhage , Arch. Otolaryng. 42:19 ( (July) ) 1945. 7. Neivert, H.; Pirk, L. A., and Engelberg, R.: Late Secondary Tonsillar Hemorrhage , Arch. Otolaryng. 43:568 ( (June) ) 1946. 8. Preston, H. G.: Postoperative Tonsil Bleeding: Studies of the Etiology, Prevention and Management , Laryngoscope 59:251 ( (March) ) 1949. 9. Butt, H. R.; Leake, W. H.; Solley, R. F.; Griffith, G. C.; Huntington, R. W., and Montgomery, H.: Studies in Rheumatic Fever: I. The Physiologic Effect of Sodium Salicylate on the Human Being with Particular Reference to the Prothrombin Level of the Blood and the Effect on Hepatic Parenchyma , J. A. M. A. 128:1195 ( (Aug. 25) ) 1945. 10. Coombs, F. S.; Warren, H. A., and Higley, C. S.: Toxicity of Salicylates , J. Lab. & Clin. Med. 30:378 ( (April) ) 1945. 11. Higley, C. S.: Use of Salicylates in Rheumatic Fever—Mixture of Aspirin and Vitamin K Unwarranted , J. A. M. A. 129:1123 ( (Dec. 15) ) 1945. 12. Livingston, G. S., and Neary, E. R.: The Question of Prothrombinopenic Hemorrhage from Post-Tonsillectomy Use of Chewing Gum Containing Acetylsalicylic Acid , Arch. Otolaryng. 47:1 ( (Jan.) ) 1948. 13. Quick, A. J.: Salicylates and Hemorrhage , J. A. M. A. 126:1167 ( (Dec. 30) ) 1944. 14. Kark, R., and Souter, A. W.: Hypoprothrombinemia and Avitaminosis K in Man , Brit. M. J. 2:190 ( (Aug. 9) ) 1941. 15. Fishman, V. P., and Lebo, C. P.: Post-Tonsillectomy Hemorrhage , Bull. Pract. Ophth. 17:1 ( (July) ) 1947. 16. Fox, S. L., and West, G. W., Jr.: Vitamin K and Late Tonsillar Hemorrhage , Laryngoscope 57:564 ( (Aug.) ) 1947. 17. Fox, S. L., and West, G. W., Jr.: Vitamins and Late Tonsillar Hemorrhage , Bull. School Med. Univ. Maryland 32:215 ( (April) ) 1948. 18. Ersner, M. S.; Myers, D., and Ersner, W.: A Clinical and Experimental Study of the Action of Saliva on Blood Coagulation and Wound Healing in Surgery of the Oral Cavity and Throat , Ann. Otol., Rhin. & Laryng. 43:114 ( (March) ) 1934. 19. Coombs, A. J.: A Study of Delayed Bleeding Following Removal of the Tonsils and Adenoids , Laryngoscope 60:296 ( (March) ) 1950. 20. The vitamin C was furnished through the courtesy of Eli Lilly & Company. 21. These doses are about half those used by Neivert, but these patients were all children; his were adults.
A.M.A. Archives of Otolaryngology – American Medical Association
Published: Mar 1, 1951
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