Abstract • This study investigated the histogenesis of the Kaposi's sarcomas occurring in young homosexual men. Paraffin sections of seven tumors were stained for factor VIII-related antigen by the unlabeled peroxidase antiperoxidase method. Both the spindle cell component and the cells lining vascular channels contained factor VIII-related antigen, a marker for endothelial cells. Our study supports the hypothesis that both components of Kaposi's sarcoma are of endothelial cell origin. (Arch Dermatol 1984;120:180-182) References 1. Kaposi M: Idiopathisches multiples pigment sarkom der Haut . Arch Dermatol 1872;4:265-273.Crossref 2. Laor Y, Schwartz RA: Epidemiologic aspects of American Kaposi's sarcoma . J Surg Oncol 1979;12:299-303.Crossref 3. Taylor JF, Templeton AC, Vogel CL, et al: Kaposi's sarcoma in Uganda: A clinicopathologic study . Int J Cancer 1971;8:125-135.Crossref 4. Harwood AR, Osoba D, Hofstader SL, et al: Kaposi's sarcoma in recipients of renal transplants . Am J Med 1979;67:759-765.Crossref 5. Penn I: Kaposi's sarcoma in organ transplant recipients: Report of 20 cases . Transplantation 1979;27:8-11.Crossref 6. Klepp 0, Dahl O, Stenwig JT: Association of Kaposi's sarcoma and prior immunosuppressive therapy: A five-year material of Kaposi's sarcoma in Norway . Cancer 1978;42:2626-2630.Crossref 7. Leung F, Fam AG, Osaba D: Kaposi's sarcoma complicating corticosteroid therapy for temporal arteritis . Am J Med 1981; 71:320-322.Crossref 8. Friedman-Kien AE, Laubenstein L, Marmor M, et al: Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men: New York and California . MMWR 1981;30:305-308. 9. Hymes K, Cheung T, Greene JB, et al: Kaposi's sarcoma in homosexual men: A report of eight cases . Lancet 1981;2:598-600.Crossref 10. Centers for Disease Control Task Force on Kaposi's sarcoma and Opportunistic Infections: Epidemiologic aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections . N Engl J Med 1982;306:248-252. 11. Fannin S, Gottlieb MS, Weisman JD, et al: A cluster of Kaposi's sarcoma and Pneumocystis carinii pneumonia among homosexual male residents of Los Angeles and Orange Counties, California . MMWR 1982;31:305-307. 12. Gottlieb GJ, Ragaz A, Vogel JV, et al: A preliminary communication on extensively disseminated Kaposi's sarcoma in young homosexual men . Am J Dermatopathol 1981;3:111-114.Crossref 13. Hymes KB, Greene JB, Marcus A, et al: Kaposi's sarcoma in homosexual men: A report of eight cases . Lancet 1981;2:598-600.Crossref 14. Stahl R, Friedman-Kien AE, Dubin R, et al: Immune abnormalities in homosexual men with Kaposi's sarcoma . Am J Med 1982;73:171-178.Crossref 15. Gottlieb MS, Schroff R, Schanken HM, et al: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men . N Engl J Med 1981;305:1425-1431.Crossref 16. Mildvan D, Mathur U, Enlow RW, et al: Opportunistic infections and immune deficiency in homosexual men . Ann Intern Med 1982;96:700-704.Crossref 17. Friedman-Kien AE, Laubenstein LJ, Rubinstein P, et al: Disseminated Kaposi's sarcoma in homosexual men . Ann Intern Med 1982;96:693-700.Crossref 18. Centers for Disease Control: Update on acquired immune deficiency syndrome (AIDS): United States . MMWR 1982;31:507-514. 19. Mukai K, Rosai J, Burgdorf WH: Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxidase method . Am J Surg Pathol 1980;4:273-276.Crossref 20. Bell DA, Flotte TJ: Factor VIII-related antigen in adenomatoid tumors: Implications for histogenesis . Cancer 1982;50:932-938.Crossref 21. Burgdorf WHC, Mukai K, Rosia J: Immunohistochemical identification of factor VIII-related antigen in endothelial cells of cutaneous lesions of alleged vascular nature . Am J Clin Pathol 1981;75:167-171. 22. Guarda JG, Silva EG, Ordonez NG, et al: Factor VIII in Kaposi's sarcoma . Am J Clin Pathol 1981;76:197-200. 23. Nadji M, Morales AR, Ziegles-Weissman J, et al: Kaposi's sarcoma . Arch Pathol Lab Med 1981;105:274-275. 24. Ackerman AB: Subtle clues to diagnosis by conventional microscopy: The patch stage of Kaposi's sarcoma . Am J Dermatopathol 1979;1:165-172.Crossref
Archives of Dermatology – American Medical Association
Published: Feb 1, 1984
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