Abstract REPORT OF A CASE A 19-month-old Albanian girl developed yellow-red papules in both eyelids at age 6 months. Over the past year, new lesions developed on her head and upper trunk. She was asymptomatic and otherwise healthy.The examination revealed multiple scattered 2- to 3-mm yellow-red papules over the scalp and face (Figure 1). A few were present on her upper chest. A complete blood cell count, serum protein electrophoresis, and chemistry panels were normal. Bone marrow aspirate, skeletal survey, chest radiograph, and computed tomographic scan were normal.Histologic findings from a typical lesion are shown (Figure 2). Special stains for CD1 and S100 were positive in a few dermal cells; HLA-DR was strongly positive. Electron microscopy was performed (Figure 3 and Figure 4).What is your diagnosis? DIAGNOSIS: Benign cephalic histiocytosis. HISTOPATHOLOGIC FINDINGS The epidermis was slightly atrophic. The dermis contained large histiocytic cells with ground-glass cytoplasm, a few multinucleated giant cells, References 1. Gianotti F, Caputo R, Ermacora E. Singuliére histiocytose infantile á cellules avec porticules vermiformes intracytoplasmiques . Bull Soc Fr Dermatol Syphiligr. 1971;78:232-233. 2. Gianotti F, Caputo R, Ermacora E, et al. Benign cephalic histiocytosis . Arch Dermatol. 1986;122:1038-1043.Crossref 3. Larralde de Luna M, Glikih I. Benign cephalic histiocytosis . Pediatr Dermatol. 1989;6:198-201.Crossref 4. Barsky B, Lao I, Barsky S, et al. Benign cephalic histiocytosis . Arch Dermatol. 1984;120:650-655.Crossref 5. Hashimoto K, Johannessen JV. The skin . In Johannessen JV, ed: Electron Microscopy in Human Medicine . New York, NY: McGraw-Hill International Book Co; 1985;11a:72-74. 6. Eisenberg E, Bronson D, Barsky S. Benign cephalic histiocytosis . J Am Acad Dermatol. 1985;12:328-331.Crossref 7. Winkelmann R, Kossard S, Fraga S. Eruptive histiocytoma of childhood . Arch Dermatol. 1980;116:565-570.Crossref 8. Gianotti F, Caputo R. Histiocytosis syndromes . J Am Acad Dermatol. 1985; 13:383-404.Crossref
Archives of Dermatology – American Medical Association
Published: May 1, 1995
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