Abstract PHEOCHROMOCYTOMA, an epinephrine- and arterenol-producing tumor, has now become recognizable and is safely removable by surgery. Graham1 estimates that in the United States more than 800 patients die annually of this disease, and many of these are avoidable deaths. More of these lesions are being reported as removed surgically before irreversible circulatory changes have occurred. This report is based on the experience of a successfully operated extra-adrenal tumor located in the left retroperitoneal para-aortic region. NATURE OF THE TUMOR This tumor has at times been called a chromaffinoma, since it arises from the cells in the chromaffin system but is known better by the term pheochromocytoma—pheo, of Greek derivation, meaning dark; chromo, from the Greek, significant of color staining dark with chrome salts; and cytoma, from the Greek, denoting cell and cell tumor. This tumor is found throughout the chromaffin system distribution; in the medulla of the adrenal References 1. Graham, J. B.: Pheochromocytoma and Hypertension: An Analysis of 207 Cases , Internat. Abstr. Surg., in Surg. Gynec. & Obst. 92:105-121, 1951. 2. Smithwick, R. H.; Greer, W. E. R.; Robertson, C. W., and Wilkins, R. W.: Pheochromocytoma: A Discussion of Symptoms, Signs and Procedure of Diagnostic Value , New England J. Med. 242:252-257, 1950. 3. Snyder, C. H., and Vick, E. H.: Hypertension in Children Caused by Pheochromocytoma , Am. J. Dis. Child. 73:581-601, 1947. 4. (a) Evans, J. A.; Rubitsky, H. J.; Bartels, C. C., and Bartels, E. C.: Re-Evaluation of the Reliability of Pharmacologic and Cold Pressor Studies in Hypertension and Pheochromocytoma , Am. J. Med. 11:448-460, 1951. 5. (b) Shapiro, A. P.; Baker, H. M.; Hoffman, M. S., and Ferris, E. B.: Pharmacologic and Physiologic Studies of a Case of Pheochromocytoma , Am. J. Med. 10:115-130, 1951. 6. (c) Richards, V., and Hatch, F. N.: Surgical Experiences with Pheochromocytoma , Ann. Surg. 134:40-54, 1951. 7. (d) Kositchek, R. J., and Rabwin, M. H.: Pheochromocytoma Successfully Removed with the Aid of Piperoxan (Benodaine) Hydrochloride , J. A. M. A. 144:826-830, 1950. 8. (e) Conley, J. C., and Junkerman, C. L.: Lack of Specificity of Piperoxane Hydrochloride Test for Adrenal Medullary Tumors , J. A. M. A. 147:92-123, 1951. 9. (f) Grimson, K. S.; Emlet, J. R., and Hamblen, E. C. Diagnosis and Management of Tumors of the Adrenal Gland , Ann. Surg. 134:451-463, 1951. 10. Graham.1 Smithwick.3 Richards.4c 11. Bartels, E. C., and Cattell, R. B.: Pheochromocytoma, Its Diagnosis and Treatment , Ann. Surg. 131:903-916, 1950. 12. Litman, N. N., and State, D.: Pheochromocytoma: Use of N,N-Dibenzyl-β-Chloroethylamine (Dibenamine®) and Piperidino-Methyl-Benzodioxane (Benzodioxane®) in Surgical Therapy , Pediatrics 4:735-743, 1949. 13. Decker, H. C.; McDowell, F. W., and Trimble, I. R.: Pheochromocytoma: Case Report with Discussion of Differential Diagnosis and Surgical Treatment , J. A. M. A. 147:642-643, 1951. 14. Grimson, K. S.; Longino, F. H.; Kernodle, C. E., and O'Rear, H. B.: Treatment of a Patient with a Pheochromocytoma , J. A. M. A. 140:1273-1274, 1949.
A.M.A. Archives Surgery – American Medical Association
Published: Jul 1, 1952
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