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External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients

External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized... Key PointsQuestionHow accurately does the Epic Sepsis Model, a proprietary sepsis prediction model implemented at hundreds of US hospitals, predict the onset of sepsis? FindingsIn this cohort study of 27 697 patients undergoing 38 455 hospitalizations, sepsis occurred in 7% of the hosptalizations. The Epic Sepsis Model predicted the onset of sepsis with an area under the curve of 0.63, which is substantially worse than the performance reported by its developer. MeaningThis study suggests that the Epic Sepsis Model poorly predicts sepsis; its widespread adoption despite poor performance raises fundamental concerns about sepsis management on a national level. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/jamainternmed.2021.2626
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionHow accurately does the Epic Sepsis Model, a proprietary sepsis prediction model implemented at hundreds of US hospitals, predict the onset of sepsis? FindingsIn this cohort study of 27 697 patients undergoing 38 455 hospitalizations, sepsis occurred in 7% of the hosptalizations. The Epic Sepsis Model predicted the onset of sepsis with an area under the curve of 0.63, which is substantially worse than the performance reported by its developer. MeaningThis study suggests that the Epic Sepsis Model poorly predicts sepsis; its widespread adoption despite poor performance raises fundamental concerns about sepsis management on a national level.

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Aug 21, 2021

References