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Extending the Ear-Kidney Association to Presbycusis

Extending the Ear-Kidney Association to Presbycusis Cystatin C and 20-Year Incidence of Hearing Impairment Original Investigation Research Invited Commentary Edwin M. Monsell, MD, PhD Understanding the causes of presbycusis is a major goal of both the age- and sex-adjusted model (hazard ratio [HR], 1.70; health research because it is such a common human condi- 95% CI, 1.16-2.48; <60 vs ≥60 mL/min/1.73 m ) and the mul- tion. The ear-kidney association has been known at least since tivariable adjusted model (HR, 1.50; 95% CI, 1.02-2.22; <60 vs the early 20th century, when the Alport and branchio-oto- ≥60 mL/min/1.73 m ).” Other analyses are described in their renal syndromes were described. It was also noted that the article. The variables used in the multivariable models in- cochlea and kidney share the cluded educational level, waist circumference, current smok- presence of pericytes and ing, glycated hemoglobin greater than 12%, and other poten- Related article page 469 podocytes in the glomeruli tial confounders. The risk of HL increased as eGFR CysC and inner ear, indicating simi- decreased toward greater degrees of renal impairment in the larities in microcirculation. The ear and kidney have in com- adjusted models. This may be some of the first evidence of the mon some http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Extending the Ear-Kidney Association to Presbycusis

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/jamaoto.2018.0275
Publisher site
See Article on Publisher Site

Abstract

Cystatin C and 20-Year Incidence of Hearing Impairment Original Investigation Research Invited Commentary Edwin M. Monsell, MD, PhD Understanding the causes of presbycusis is a major goal of both the age- and sex-adjusted model (hazard ratio [HR], 1.70; health research because it is such a common human condi- 95% CI, 1.16-2.48; <60 vs ≥60 mL/min/1.73 m ) and the mul- tion. The ear-kidney association has been known at least since tivariable adjusted model (HR, 1.50; 95% CI, 1.02-2.22; <60 vs the early 20th century, when the Alport and branchio-oto- ≥60 mL/min/1.73 m ).” Other analyses are described in their renal syndromes were described. It was also noted that the article. The variables used in the multivariable models in- cochlea and kidney share the cluded educational level, waist circumference, current smok- presence of pericytes and ing, glycated hemoglobin greater than 12%, and other poten- Related article page 469 podocytes in the glomeruli tial confounders. The risk of HL increased as eGFR CysC and inner ear, indicating simi- decreased toward greater degrees of renal impairment in the larities in microcirculation. The ear and kidney have in com- adjusted models. This may be some of the first evidence of the mon some

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jun 26, 2018

References