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EXPERIMENTAL STUDIES IN ALCOHOLISM: II. THE ALCOHOL CONTENT OF THE BLOOD AND CEREBROSPINAL FLUID FOLLOWING INTRAVENOUS ADMINISTRATION OF ALCOHOL IN CHRONIC ALCOHOLISM AND THE PSYCHOSES

EXPERIMENTAL STUDIES IN ALCOHOLISM: II. THE ALCOHOL CONTENT OF THE BLOOD AND CEREBROSPINAL FLUID... Abstract In the first part of this investigation,1 based on a study of fifty-two cases, we were able to demonstrate that following the oral ingestion of standard doses of alcohol certain differences exist in the curves for the alcohol content of the blood and spinal fluid, depending on the drinking habits of the subjects. It was found that in the heavy drinkers as a group the alcohol content of the blood after ingestion increases more rapidly, reaches a higher peak and decreases more quickly than in the abstainers; the values for the group of moderate drinkers occupy an intermediate position in all three respects. As far as the curves for the alcohol content of the spinal fluid are concerned, those for the heavy drinkers rise more rapidly, reach a slightly higher peak and decline more quickly than those for the abstainers; for the moderate drinkers, however, the curves for the References 1. Fleming, R., and Stotz, E.: Experimental Studies in Alcoholism: I. Alcohol Content of the Blood and Cerebrospinal Fluid Following Oral Administration in Chronic Alcoholism and the Psychoses , Arch. Neurol. & Psychiat. 33: 492 ( (March) ) 1935. 2. Rothschild, D., and Burke, E. R.: Blood-Cerebrospinal Fluid Barrier in Alcoholic Disorders and in Schizophrenia Complicated by Alcoholism , Arch. Neurol. & Psychiat. 30:141 ( (July) ) 1933. 3. Gabbe, E.: Ueber den Gehalt des Blutes an Alkohol nach intravenöser Injektion desselben beim Menschen , Deutsches Arch. f. klin. Med. 122:81, 1917. 4. Mehrtens, H. G., and Newman, H. W.: Alcohol Injected Intravenously: Its Penetration into the Cerebrospinal Fluid in Man , Arch. Neurol. & Psychiat. 30:1092 ( (Nov.) ) 1933. 5. Emerson, H.: Alcohol and Man , New York, The Macmillan Company, 1932, pp. 5, 10, 130 and 201. 6. Faure, W., and Loewe, S.: Der Alkoholspiegel im Blute gewöhnter und ungewöhnter Kaninchen nach einem Probetrung , Biochem. Ztschr. 143:47, 1923. 7. Dr. Frank Fremont-Smith, we investigated the concentration of alcohol of blood plasma as compared to that of whole blood and were able to confirm the findings of Miles ( J. Pharmacol. & Exper. Therap. 20: 265, 1922) 8. Bull. Soc. chim. biol. 16:330, 1934 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EXPERIMENTAL STUDIES IN ALCOHOLISM: II. THE ALCOHOL CONTENT OF THE BLOOD AND CEREBROSPINAL FLUID FOLLOWING INTRAVENOUS ADMINISTRATION OF ALCOHOL IN CHRONIC ALCOHOLISM AND THE PSYCHOSES

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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1936.02260010127010
Publisher site
See Article on Publisher Site

Abstract

Abstract In the first part of this investigation,1 based on a study of fifty-two cases, we were able to demonstrate that following the oral ingestion of standard doses of alcohol certain differences exist in the curves for the alcohol content of the blood and spinal fluid, depending on the drinking habits of the subjects. It was found that in the heavy drinkers as a group the alcohol content of the blood after ingestion increases more rapidly, reaches a higher peak and decreases more quickly than in the abstainers; the values for the group of moderate drinkers occupy an intermediate position in all three respects. As far as the curves for the alcohol content of the spinal fluid are concerned, those for the heavy drinkers rise more rapidly, reach a slightly higher peak and decline more quickly than those for the abstainers; for the moderate drinkers, however, the curves for the References 1. Fleming, R., and Stotz, E.: Experimental Studies in Alcoholism: I. Alcohol Content of the Blood and Cerebrospinal Fluid Following Oral Administration in Chronic Alcoholism and the Psychoses , Arch. Neurol. & Psychiat. 33: 492 ( (March) ) 1935. 2. Rothschild, D., and Burke, E. R.: Blood-Cerebrospinal Fluid Barrier in Alcoholic Disorders and in Schizophrenia Complicated by Alcoholism , Arch. Neurol. & Psychiat. 30:141 ( (July) ) 1933. 3. Gabbe, E.: Ueber den Gehalt des Blutes an Alkohol nach intravenöser Injektion desselben beim Menschen , Deutsches Arch. f. klin. Med. 122:81, 1917. 4. Mehrtens, H. G., and Newman, H. W.: Alcohol Injected Intravenously: Its Penetration into the Cerebrospinal Fluid in Man , Arch. Neurol. & Psychiat. 30:1092 ( (Nov.) ) 1933. 5. Emerson, H.: Alcohol and Man , New York, The Macmillan Company, 1932, pp. 5, 10, 130 and 201. 6. Faure, W., and Loewe, S.: Der Alkoholspiegel im Blute gewöhnter und ungewöhnter Kaninchen nach einem Probetrung , Biochem. Ztschr. 143:47, 1923. 7. Dr. Frank Fremont-Smith, we investigated the concentration of alcohol of blood plasma as compared to that of whole blood and were able to confirm the findings of Miles ( J. Pharmacol. & Exper. Therap. 20: 265, 1922) 8. Bull. Soc. chim. biol. 16:330, 1934

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jan 1, 1936

References