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EXPERIMENTAL SHOCK: THE EFFECTS OF EXTRACTS FROM TRAUMATIZED LIMBS ON THE BLOOD PRESSURE

EXPERIMENTAL SHOCK: THE EFFECTS OF EXTRACTS FROM TRAUMATIZED LIMBS ON THE BLOOD PRESSURE Abstract Of the various theories suggested as to the mechanism of traumatic shock, two have recently received most attention, viz: (1) that of the absorption of metabolic toxins from the traumatized area with secondary generalized vasodilatation and increased permeability of the capillaries, a theory advocated by Cannon,1 Cannon and Bayliss,2 and others, and (2) that of the local loss of blood or plasma, or both, resulting in a serious decrease in the volume of circulating blood, as supported by the work of Blalock,3 Phemister and co-workers,4 Freedlander and Lenhart5 and others. Various investigators (Mason and Lemon,6 Carlson, Woelfel and Powell,7 Popielski8 and Bayliss9) have shown that extracts of many tissues contain substances which depress the blood pressure, and this fact has been frequently cited10 in support of the "toxic theory" of traumatic shock. Carlson, Woelfel and Powell,7 however, after examining References 1. Cannon, W. B.: Traumatic Shock , New York, D. Appleton & Company, 1923. 2. Cannon, W. B., and Bayliss, W. M.: Note on Muscle Injury in Relation to Shock , Medical Research Council, Spec. Res. Ser. no. 26, London, His Majesty's Stationery Office, 1919, p. 19. 3. Blalock, A.: The Cause of the Low Blood Pressure Produced by Muscle Injury in Dogs , Arch. Surg. 20:959 ( (June) ) 1930.Crossref 4. Parsons, E., and Phemister, D. B.: Haemorrhage and Shock in Traumatized Limbs , Surg., Gynec. & Obst. 51:196 ( (Aug.) ) 1930. 5. Roome, N. W.; Keith, W. S., and Phemister, D. B.: The Effect of Bleeding After Reduction of the Blood Pressure by Various Methods , Surg., Gynec. & Obst. 56:161 ( (Feb.) ) 1933. 6. Freedlander, S. O., and Lenhart, C. H.: Traumatic Shock , Arch. Surg. 25:693 ( (Oct.) ) 1932. 7. Mason, E. C., and Lemon, C. W.: Autointoxication and Shock , Surg., Gynec. & Obst. 53:60 ( (July) ) 1931. 8. Carlson, A. J.; Woelfel, A., and Powell, W. H.: A Possible Hormone Vasomotor Mechanism , Proc. Am. Physiol. Soc. , 1908, p. 23. 9. Popielski, L.: Ueber die physiologische Wirkung von Extrakten aus sämtlichen Teilen des Verdauungskanales , Arch. f. d. ges. Physiol. 128:191, 1909. 10. Bayliss, W. M.: Principles of General Physiology , ed. 4, New York, Longmans, Green & Co., 1924, p. 701. 11. Moon, V. H., and Kennedy, P. J.: Pathology of Shock , Arch. Path. 14:360 ( (Sept.) ) 1932. 12. Tigerstedt and Bergman: Skandinav. Arch. f. Physiol. 8:223, 1898 13. Collip, J. B.: A Non-Specific Pressor Principle Derived from a Variety of Tissues , J. Physiol. 66:416 ( (Dec.) ) 1928. 14. Phemister, D. B., and Handy, J.: Vascular Properties of Traumatized and Laked Bloods , J. Physiol. 64:155 ( (Nov.) ) 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EXPERIMENTAL SHOCK: THE EFFECTS OF EXTRACTS FROM TRAUMATIZED LIMBS ON THE BLOOD PRESSURE

Archives of Surgery , Volume 31 (3) – Sep 1, 1935

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1935.01180150018002
Publisher site
See Article on Publisher Site

Abstract

Abstract Of the various theories suggested as to the mechanism of traumatic shock, two have recently received most attention, viz: (1) that of the absorption of metabolic toxins from the traumatized area with secondary generalized vasodilatation and increased permeability of the capillaries, a theory advocated by Cannon,1 Cannon and Bayliss,2 and others, and (2) that of the local loss of blood or plasma, or both, resulting in a serious decrease in the volume of circulating blood, as supported by the work of Blalock,3 Phemister and co-workers,4 Freedlander and Lenhart5 and others. Various investigators (Mason and Lemon,6 Carlson, Woelfel and Powell,7 Popielski8 and Bayliss9) have shown that extracts of many tissues contain substances which depress the blood pressure, and this fact has been frequently cited10 in support of the "toxic theory" of traumatic shock. Carlson, Woelfel and Powell,7 however, after examining References 1. Cannon, W. B.: Traumatic Shock , New York, D. Appleton & Company, 1923. 2. Cannon, W. B., and Bayliss, W. M.: Note on Muscle Injury in Relation to Shock , Medical Research Council, Spec. Res. Ser. no. 26, London, His Majesty's Stationery Office, 1919, p. 19. 3. Blalock, A.: The Cause of the Low Blood Pressure Produced by Muscle Injury in Dogs , Arch. Surg. 20:959 ( (June) ) 1930.Crossref 4. Parsons, E., and Phemister, D. B.: Haemorrhage and Shock in Traumatized Limbs , Surg., Gynec. & Obst. 51:196 ( (Aug.) ) 1930. 5. Roome, N. W.; Keith, W. S., and Phemister, D. B.: The Effect of Bleeding After Reduction of the Blood Pressure by Various Methods , Surg., Gynec. & Obst. 56:161 ( (Feb.) ) 1933. 6. Freedlander, S. O., and Lenhart, C. H.: Traumatic Shock , Arch. Surg. 25:693 ( (Oct.) ) 1932. 7. Mason, E. C., and Lemon, C. W.: Autointoxication and Shock , Surg., Gynec. & Obst. 53:60 ( (July) ) 1931. 8. Carlson, A. J.; Woelfel, A., and Powell, W. H.: A Possible Hormone Vasomotor Mechanism , Proc. Am. Physiol. Soc. , 1908, p. 23. 9. Popielski, L.: Ueber die physiologische Wirkung von Extrakten aus sämtlichen Teilen des Verdauungskanales , Arch. f. d. ges. Physiol. 128:191, 1909. 10. Bayliss, W. M.: Principles of General Physiology , ed. 4, New York, Longmans, Green & Co., 1924, p. 701. 11. Moon, V. H., and Kennedy, P. J.: Pathology of Shock , Arch. Path. 14:360 ( (Sept.) ) 1932. 12. Tigerstedt and Bergman: Skandinav. Arch. f. Physiol. 8:223, 1898 13. Collip, J. B.: A Non-Specific Pressor Principle Derived from a Variety of Tissues , J. Physiol. 66:416 ( (Dec.) ) 1928. 14. Phemister, D. B., and Handy, J.: Vascular Properties of Traumatized and Laked Bloods , J. Physiol. 64:155 ( (Nov.) ) 1927.

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1935

References