Abstract It is known that an experimental tumor on transplantation invariably reproduces the same kind of tumor as to cell type. For instance, the Rous sarcoma always produces a fibrosarcoma whether it is injected into muscle, bone, connective tissue or an internal organ, such as the liver. When, therefore, an opportunity came to work with an endothelioma, I seized the chance to observe its behavior when injected into the bonemarrow of chickens. The purpose of such a procedure was several fold. First, it was desired to see to what extent it might produce a tumor resembling the much disputed tumor described by Ewing as an endothelioma of bone. Second, it seemed important to watch the development of tumor of the bone-marrow from its inception, a thing impossible to do in man, since in the latter it usually has advanced considerably before it is discovered. Third, the reaction of the bone itself References 1. Connor, C. L.: Endothelial Myeloma, Ewing , Arch. Surg. 12:789 ( (April) ) 1926.Crossref 2. Codman, E. A.: The Nomenclature Used by the Registry of Bone Sarcoma , Am. J. Roentgenol. 13:105, 1925. 3. Eising, E. H.: Bone Formation in Osteogenic Sarcoma: Teleologic Considerations , Arch. Surg. 12:867 ( (April) ) 1926.Crossref 4. Keibel and Mall: Human Embryology , Philadelphia, J. B. Lippincott Company, 1910, vol. 1, p. 303. 5. Moschcowitz, E.: The Relation of Angiogenesis to Ossification , Bull. Johns Hopkins Hosp. 27:71, 1916. 6. Maximow, A. A.: Relation of Blood Cells to Connective Tissue and Endothelium , Physiol. Rev. 4:533, 1924. 7. Fischer, A.: Sur la transformation in vitro des gros leucocytes mononucléaires en fibroblasts , Compt. rend. Soc. de biol. 92:109, 1925. 8. Carrel, A., and Ebeling, A. H.: Pure Cultures of Large Mononuclear Leucocytes , J. Exper. Med. 36:365, 1922.Crossref 9. Maximow, A. A.: Development of Nongranular Leucocytes (Lymphocytes and Monocytes) into Polyblasts (Macrophages) and Fibroblasts in Vitro , Proc. Soc. Exper. Biol. & Med. 24:570, 1927.
Archives of Surgery – American Medical Association
Published: Nov 1, 1929