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Experimental Retinal Detachment: I. Effect of Subretinal Fluid Composition on Reabsorption Rate and Intraocular Pressure

Experimental Retinal Detachment: I. Effect of Subretinal Fluid Composition on Reabsorption Rate... Abstract • Retinal detachments (RDs) were produced in rhesus monkeys by a 1-mL subretinal fluid injection combined with simultaneous vitreous aspiration. Four groups of five eyes each were studied according to type of fluid injected: autologous serum, glutathione-bicarbonate Ringer's solution (GBR), silicone oil, or no fluid (sham operation). Retinal detachments created with GBR reattached within two to seven days; RDs created with serum decreased in volume at a rate ten times slower than that of eyes detached with GBR; RDs created with silicone oil and sham-operation eyes remained unchanged during three weeks of observation. Active transport of fluid out of the subretinal space best explains these findings. Transient hypotony developed in all eyes in association with postoperative inflammation and reduced aqueous humor formation. Eyes with persistent detachment (serum and silicone oil) retained mild hypotony three weeks after operation, suggesting a pressure-lowering effect of the detachment itself. References 1. Robertson DM: Delayed absorption of subretinal fluid and episcleral buckling procedures . Am J Ophthalmol 1979;87:57-64. 2. Hayasaka S, Hara S, Mizuno K: Lysosomal enzymes in subretinal fluid . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1976;200:13-20.Crossref 3. Akhmeteli LM, Kasavina DS, Petropavlovskajaga GA: Biochemical investigation of the subretinal fluid . Br J Ophthalmol 1975;59:70-77.Crossref 4. Himi T: Total protein concentration of subretinal fluid in rhegmatogenous detachment of the retina . Soc Ophthalmol Jpn 1975;79:1865-1878. 5. Chignell AH, Carruthers M, Rahi AHS: Clinical, biochemical, and immunoelectrophoretic study of subretinal fluid . Br J Ophthalmol 1971;55:525-532.Crossref 6. Edmund J: Analysis of the subretinal fluid: Measurement of the oncotic pressure . Acta Ophthalmol 1968;46:1184-1193.Crossref 7. Gortz H: Zur Frage der Behandlung des retroretinalen Ergusses beil Operationen gegen die Netzhautablosung . Mod Probl Ophthalmol 1965;3:55-64. 8. Weber JC, Wilson FM: Biochemical studies of subretinal fluid: II. Total protein and albumin of the subretinal fluid and blood serum in patients with retinal detachment . Arch Ophthalmol 1963;69:363-369.Crossref 9. Heath H, Beck TC, Foulds WS: Chemical composition of subretinal fluid . Br J Ophthalmol 1962;46:385-396.Crossref 10. Leaver PK, Chester GH, Saunders SH: Factors influencing absorption of subretinal fluid . Br J Ophthalmol 1976;60:557-560.Crossref 11. Marmor MF, Abdul-Rahim AS, Cohen DS: The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorbtion . Invest Ophthalmol Vis Sci 1980;19:893-903. 12. Pederson JE, Gaasterland DE, MacLellan HM: Experimental ciliochoroidal detachment . Arch Ophthalmol 1979;97:536-541.Crossref 13. Cevario SJ, Macri FJ: The inhibitory effect of pentobarbital Na on aqueous humor formation . Invest Ophthalmol Vis Sci 1974;13:384-386. 14. O'Connor PR: Absorption of the subretinal fluid after external scleral buckling without drainage . Am J Ophthalmol 1973;76:30-34. 15. Kaufman PL, Podos SM: Subretinal fluid butyrylcholinesterase: I. Source of the enzyme and factors affecting its concentration in subretinal fluid from primary rhegmatogenous retinal detachments . Am J Ophthalmol 1973;75:627-636. 16. Van Alphen GWHM: On emmetropia and ametropia . Ophthalmologica 1961;142( (suppl) ):1-92.Crossref 17. Scott JD: Retinal detachment surgery without drainage . Trans Ophthalmol Soc UK 1970;90:57-77. 18. Foulds WS: Clinical significance of transscleral fluid transfer . Trans Ophthalmol Soc UK 1976;96:290-308. 19. Machemer R, Norton EWD: Experimental retinal detachment in the owl monkey: I. Methods of production and clinical picture . Am J Ophthalmol 1968;66:388-396. 20. Langham ME, Regan CDJ: Circulatory changes associated with onset of primary retinal detachment . Arch Ophthalmol 1969;81:820-829.Crossref 21. Dobbie JG: A study of the intraocular fluid dynamics in retinal detachment . Arch Ophthalmol 1963;69:159-164.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Experimental Retinal Detachment: I. Effect of Subretinal Fluid Composition on Reabsorption Rate and Intraocular Pressure

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040128023
Publisher site
See Article on Publisher Site

Abstract

Abstract • Retinal detachments (RDs) were produced in rhesus monkeys by a 1-mL subretinal fluid injection combined with simultaneous vitreous aspiration. Four groups of five eyes each were studied according to type of fluid injected: autologous serum, glutathione-bicarbonate Ringer's solution (GBR), silicone oil, or no fluid (sham operation). Retinal detachments created with GBR reattached within two to seven days; RDs created with serum decreased in volume at a rate ten times slower than that of eyes detached with GBR; RDs created with silicone oil and sham-operation eyes remained unchanged during three weeks of observation. Active transport of fluid out of the subretinal space best explains these findings. Transient hypotony developed in all eyes in association with postoperative inflammation and reduced aqueous humor formation. Eyes with persistent detachment (serum and silicone oil) retained mild hypotony three weeks after operation, suggesting a pressure-lowering effect of the detachment itself. References 1. Robertson DM: Delayed absorption of subretinal fluid and episcleral buckling procedures . Am J Ophthalmol 1979;87:57-64. 2. Hayasaka S, Hara S, Mizuno K: Lysosomal enzymes in subretinal fluid . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1976;200:13-20.Crossref 3. Akhmeteli LM, Kasavina DS, Petropavlovskajaga GA: Biochemical investigation of the subretinal fluid . Br J Ophthalmol 1975;59:70-77.Crossref 4. Himi T: Total protein concentration of subretinal fluid in rhegmatogenous detachment of the retina . Soc Ophthalmol Jpn 1975;79:1865-1878. 5. Chignell AH, Carruthers M, Rahi AHS: Clinical, biochemical, and immunoelectrophoretic study of subretinal fluid . Br J Ophthalmol 1971;55:525-532.Crossref 6. Edmund J: Analysis of the subretinal fluid: Measurement of the oncotic pressure . Acta Ophthalmol 1968;46:1184-1193.Crossref 7. Gortz H: Zur Frage der Behandlung des retroretinalen Ergusses beil Operationen gegen die Netzhautablosung . Mod Probl Ophthalmol 1965;3:55-64. 8. Weber JC, Wilson FM: Biochemical studies of subretinal fluid: II. Total protein and albumin of the subretinal fluid and blood serum in patients with retinal detachment . Arch Ophthalmol 1963;69:363-369.Crossref 9. Heath H, Beck TC, Foulds WS: Chemical composition of subretinal fluid . Br J Ophthalmol 1962;46:385-396.Crossref 10. Leaver PK, Chester GH, Saunders SH: Factors influencing absorption of subretinal fluid . Br J Ophthalmol 1976;60:557-560.Crossref 11. Marmor MF, Abdul-Rahim AS, Cohen DS: The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorbtion . Invest Ophthalmol Vis Sci 1980;19:893-903. 12. Pederson JE, Gaasterland DE, MacLellan HM: Experimental ciliochoroidal detachment . Arch Ophthalmol 1979;97:536-541.Crossref 13. Cevario SJ, Macri FJ: The inhibitory effect of pentobarbital Na on aqueous humor formation . Invest Ophthalmol Vis Sci 1974;13:384-386. 14. O'Connor PR: Absorption of the subretinal fluid after external scleral buckling without drainage . Am J Ophthalmol 1973;76:30-34. 15. Kaufman PL, Podos SM: Subretinal fluid butyrylcholinesterase: I. Source of the enzyme and factors affecting its concentration in subretinal fluid from primary rhegmatogenous retinal detachments . Am J Ophthalmol 1973;75:627-636. 16. Van Alphen GWHM: On emmetropia and ametropia . Ophthalmologica 1961;142( (suppl) ):1-92.Crossref 17. Scott JD: Retinal detachment surgery without drainage . Trans Ophthalmol Soc UK 1970;90:57-77. 18. Foulds WS: Clinical significance of transscleral fluid transfer . Trans Ophthalmol Soc UK 1976;96:290-308. 19. Machemer R, Norton EWD: Experimental retinal detachment in the owl monkey: I. Methods of production and clinical picture . Am J Ophthalmol 1968;66:388-396. 20. Langham ME, Regan CDJ: Circulatory changes associated with onset of primary retinal detachment . Arch Ophthalmol 1969;81:820-829.Crossref 21. Dobbie JG: A study of the intraocular fluid dynamics in retinal detachment . Arch Ophthalmol 1963;69:159-164.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1982

References