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Experimental Respiratory Insufficiency: Attempted Correction With Membrane Oxygenator

Experimental Respiratory Insufficiency: Attempted Correction With Membrane Oxygenator Abstract THE RESPIRATORY distress syndrome (RDS) accounts for a large proportion of deaths in the newborn period. Controversy exists over which cases should be included, since the diagnosis cannot be made securely during life. The smaller the baby, the more likelihood of having the syndrome. Thus, according to Usher,1 14% of prematures are affected, the incidence being 50% in those weighing between 1,000 and 1,500 gm (2.2 and 3.3 lb) and 5% between 2,000 and 2,500 gm (4.4 and 5.5 lb). Fifty percent of those affected die and 80% of the deaths are between 12 and 72 hours of age. The mortality rate of babies alive with the disease at 48 hours is 25% and at 72 hours it is 11%. Despite the improved understanding of RDS in recent years, the basic cause remains unknown. Because some infants improve after being critically ill, it is tempting to consider the disease References 1. Spinlab, Knoxville, Tenn. 2. Usher, R.: The Respiratory Distress Syndrome of Prematurity: Clinical and Therapeutic Aspects , Pediat Clin N Amer 8:525, 1961. 3. Dobell, A.R.C., et al: Biologic Evaluation of Blood After Prolonged Recirculation Through Film and Membrane Oxygenator , Ann Surg 161:617, 1965.Crossref 4. Lee, W.H., et al: Denaturation of Plasma Proteins as a Cause of Morbidity and Death After Intracardiac Operations , Surgery 50:29, 1961. 5. Peirce, E.C., II: The Membrane Lung: A New Multiple Point Support for Teflon Film , Surgery 52:777, 1962. 6. Callaghan, J.C., et al: Study of Prepulmonary Bypass in Development of an Artificial Placenta for Prematurity and Respiratory Distress Syndrome of the Newborn , J Thor Cardiov Surg 44:600, 1962. 7. Salisbury, P.F., et al: Comparison of Two Types of Mechanical Assistance in Experimental Heart Failure , Circ Res 8:431, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Experimental Respiratory Insufficiency: Attempted Correction With Membrane Oxygenator

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1965.01320180015004
Publisher site
See Article on Publisher Site

Abstract

Abstract THE RESPIRATORY distress syndrome (RDS) accounts for a large proportion of deaths in the newborn period. Controversy exists over which cases should be included, since the diagnosis cannot be made securely during life. The smaller the baby, the more likelihood of having the syndrome. Thus, according to Usher,1 14% of prematures are affected, the incidence being 50% in those weighing between 1,000 and 1,500 gm (2.2 and 3.3 lb) and 5% between 2,000 and 2,500 gm (4.4 and 5.5 lb). Fifty percent of those affected die and 80% of the deaths are between 12 and 72 hours of age. The mortality rate of babies alive with the disease at 48 hours is 25% and at 72 hours it is 11%. Despite the improved understanding of RDS in recent years, the basic cause remains unknown. Because some infants improve after being critically ill, it is tempting to consider the disease References 1. Spinlab, Knoxville, Tenn. 2. Usher, R.: The Respiratory Distress Syndrome of Prematurity: Clinical and Therapeutic Aspects , Pediat Clin N Amer 8:525, 1961. 3. Dobell, A.R.C., et al: Biologic Evaluation of Blood After Prolonged Recirculation Through Film and Membrane Oxygenator , Ann Surg 161:617, 1965.Crossref 4. Lee, W.H., et al: Denaturation of Plasma Proteins as a Cause of Morbidity and Death After Intracardiac Operations , Surgery 50:29, 1961. 5. Peirce, E.C., II: The Membrane Lung: A New Multiple Point Support for Teflon Film , Surgery 52:777, 1962. 6. Callaghan, J.C., et al: Study of Prepulmonary Bypass in Development of an Artificial Placenta for Prematurity and Respiratory Distress Syndrome of the Newborn , J Thor Cardiov Surg 44:600, 1962. 7. Salisbury, P.F., et al: Comparison of Two Types of Mechanical Assistance in Experimental Heart Failure , Circ Res 8:431, 1960.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1965

References