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Experimental Pulmonary Fat Embolism: Effects on Pulmonary Function by Reserpine Pretreatment

Experimental Pulmonary Fat Embolism: Effects on Pulmonary Function by Reserpine Pretreatment Abstract Two groups of eight dogs each received injections of olive oil (1.5 ml/kg) after control measurements were taken. One group was pretreated with reserpine (0.25 mg/kg) for two days. Both groups had the same initial changes in hemodynamics and pulmonary function. However, by three to five hours the reserpine-treated group clearly had less arterial hypoxia (oxygen pressure [PAO2] 77.1 vs 55 mm Hg) on the basis of a smaller calculated pulmonary shunt (9.92% vs 14.9%), and on the basis of a higher cardiac output (63% vs 55% of initial value). References 1. Peltier LF: An appraisal of the problem of fat embolism . Surg Gynec Obstet 104:313-324, 1957. 2. Bruecke P, Burke JF, Lam KW, et al: The pathophysiology of pulmonary fat embolism . J Thorac Cardiovasc Surg 61:949-955, 1971. 3. Bergentz SE: Studies on the genesis of post traumatic fat embolism . Acta Chir Scand , (suppl 282) , pp 1-72, 1961. 4. Liljedahl SO, Westermark L: Aetiology and treatment of fat embolism . Acta Anaesth Scand 11:177-194, 1967.Crossref 5. Peltier LF: Fat embolism: A pulmonary disease . Surgery 62:756-758, 1967. 6. Smith G, Smith AN: The role of serotonin in experimental pulmonary embolism . Surg Gynec Obstet 101:691-700, 1955. 7. Haverback BJ, Dutcher TF, Shore PA, et al: Serotonin changes in platelets and brain induced by small daily doses of reserpine . New Eng J Med 256:343-345, 1957.Crossref 8. Rosoff CB, Salzman EW, Gurewich V, et al: Reduction of platelet serotonin and the response to pulmonary emboli . Surgery 70:12-19, 1971. 9. Waud DR, Kottegoda SR, Krayer O: Threshold dose and time course of norepinephrine depletion of the mammalian heart by reserpine . J Pharmacol Exp Ther 124:340-346, 1958. 10. McLaughlin JS, Buckley MJ, Berry WB, et al: Pulmonary vascular dynamics during acute hypoxia: Modification by reserpine pretreatment or adrenalectomy . Surgery 59:1031-1036, 1966. 11. Massion CG, Seligson D: Serum lipase: A rapid photometric method . Amer J Clin Path 48:307-313, 1967. 12. Daicoff GR, Chavez FR, Anton AH, et al: Serotonin-induced pulmonary venous hypertension in pulmonary embolism . J Thorac Cardiovasc Surg 56:810-816, 1968. 13. Sukhnandan R, Thai AP: The effect of endotoxin and vasoactive agents on Dibenzyline-pretreated lungs . Surgery 58:185-196, 1965. 14. Carlson LA, Liljedahl SO: Lipid metabolism and trauma . Acta Med Scand 173:787-793, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Experimental Pulmonary Fat Embolism: Effects on Pulmonary Function by Reserpine Pretreatment

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1972.04180080127021
Publisher site
See Article on Publisher Site

Abstract

Abstract Two groups of eight dogs each received injections of olive oil (1.5 ml/kg) after control measurements were taken. One group was pretreated with reserpine (0.25 mg/kg) for two days. Both groups had the same initial changes in hemodynamics and pulmonary function. However, by three to five hours the reserpine-treated group clearly had less arterial hypoxia (oxygen pressure [PAO2] 77.1 vs 55 mm Hg) on the basis of a smaller calculated pulmonary shunt (9.92% vs 14.9%), and on the basis of a higher cardiac output (63% vs 55% of initial value). References 1. Peltier LF: An appraisal of the problem of fat embolism . Surg Gynec Obstet 104:313-324, 1957. 2. Bruecke P, Burke JF, Lam KW, et al: The pathophysiology of pulmonary fat embolism . J Thorac Cardiovasc Surg 61:949-955, 1971. 3. Bergentz SE: Studies on the genesis of post traumatic fat embolism . Acta Chir Scand , (suppl 282) , pp 1-72, 1961. 4. Liljedahl SO, Westermark L: Aetiology and treatment of fat embolism . Acta Anaesth Scand 11:177-194, 1967.Crossref 5. Peltier LF: Fat embolism: A pulmonary disease . Surgery 62:756-758, 1967. 6. Smith G, Smith AN: The role of serotonin in experimental pulmonary embolism . Surg Gynec Obstet 101:691-700, 1955. 7. Haverback BJ, Dutcher TF, Shore PA, et al: Serotonin changes in platelets and brain induced by small daily doses of reserpine . New Eng J Med 256:343-345, 1957.Crossref 8. Rosoff CB, Salzman EW, Gurewich V, et al: Reduction of platelet serotonin and the response to pulmonary emboli . Surgery 70:12-19, 1971. 9. Waud DR, Kottegoda SR, Krayer O: Threshold dose and time course of norepinephrine depletion of the mammalian heart by reserpine . J Pharmacol Exp Ther 124:340-346, 1958. 10. McLaughlin JS, Buckley MJ, Berry WB, et al: Pulmonary vascular dynamics during acute hypoxia: Modification by reserpine pretreatment or adrenalectomy . Surgery 59:1031-1036, 1966. 11. Massion CG, Seligson D: Serum lipase: A rapid photometric method . Amer J Clin Path 48:307-313, 1967. 12. Daicoff GR, Chavez FR, Anton AH, et al: Serotonin-induced pulmonary venous hypertension in pulmonary embolism . J Thorac Cardiovasc Surg 56:810-816, 1968. 13. Sukhnandan R, Thai AP: The effect of endotoxin and vasoactive agents on Dibenzyline-pretreated lungs . Surgery 58:185-196, 1965. 14. Carlson LA, Liljedahl SO: Lipid metabolism and trauma . Acta Med Scand 173:787-793, 1963.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1972

References