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Experimental Production of Acne by Progesterone

Experimental Production of Acne by Progesterone Abstract There is general recognition today that there may be many factors in the etiology of acne vulgaris. Thus there are hereditary, nutritional, climatic, emotional, bacterial, and, particularly, endocrinal influences. Sebaceous glands, relatively small during childhood, start to grow rapidly with the onset of puberty. At the same time there is a considerable increase in the amount of sebum excreted to the skin surface. This sebaceous hyperfunction is the cause of seborrhea in adolescence and is considered to be a major component of acne vulgaris.1 In males the role of testicular androgens in sebaceous hyperfunction has long been recognized.2 In females, adrenal androgens have been held responsible for pubertal seborrhea, but recent studies have called attention to the part played here by another hormone. Progesterone, the active principle produced by the corpus luteum, has been shown to have the same effects as testosterone in causing References 1. Courtesy, Schering Corporation, Bloomfield, N. J., which supplied Proluton 50 mg/cc. 2. Margaret Merrell, Sc.D., Department of Biostatistics, School of Hygiene and Public Health, The Johns Hopkins University: Personal communication to the authors. 3. Rothman, S.: Physiology and Pathology of Sebaceous Gland Secretion , Tr. St. Johns' Hospital Dermat. Soc. 33:1-6 ( (Oct.) ) 1954. 4. Hamilton, J. B.: Male Hormone Substance: A Prime Factor in Acne , J. Clin. Endocrinol. 1:570-592 ( (July) ) 1941.Crossref 5. Haskin, D.; Lasher, N., and Rothman, S.: Some Effects of ACTH, Cortisone, Progesterone and Testosterone on Sebaceous Glands in the White Rat , J. Invest. Dermat. 20:207-212 ( (March) ) 1953. 6. Malkinson, F. D.: Acne Vulgaris , J. A. M. A. 159:1117-1119 ( (Nov. 12) ) 1955.Crossref 7. Shelley, W. B., and Cahn, M. M.: Experimental Studies on the Effect of Hormones on the Human Skin with Reference to the Axillary Apocrine Sweat Gland , J. Invest. Dermat. 25:127-131 ( (Aug.) ) 1955.Crossref 8. Rony, H. R., and Zakon, S. J.: Effect of Androgen on the Sebaceous Glands of Human Skin , Arch. Dermat. & Syph. 48:601-604 ( (Dec.) ) 1943. 9. DeGraaf, H. J.: Endocrine Influences on Sebaceous Glands , Acta Brev. Neerl. 12:67-68, 1942. 10. Ebling, F. J.: Sebaceous Glands: 1. The Effect of Sex Hormones on the Sebaceous Glands of the Female Albino Rat , J. Endocrinol. 5:297-302 ( (June) ) 1948. 11. Hamilton, J. B., and Montagna, W.: The Sebaceous Glands of the Hamster: I. Morphological Effects of Androgens on Integumentary Structures , Am. J. Anat. 86:191-234, 1950. 12. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954. 13. Sullivan, M., and Zeligman, I.: Acneform Eruption Due to Corticotropin , A. M. A. Arch. Dermat. 73:133-141 ( (Feb.) ) 1956. 14. Baker, B. L.; Ingle, D. J.; Li, C. H., and Evans, H. M.: Growth Inhibition in the Skin Induced by Parenteral Administration of Adrenocorticotropin , Anat. Rec. 102:313-331 ( (Nov.) ) 1948. 15. Aron-Brunetière, R.: An Attempt at a Physiopathological Explanation of Seborrhea and Acne Vulgaris: Therapeutic Results , Brit. J. Dermat. 65:157-164 ( (May) ) 1953. 16. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in The White Rat: II. The Effect of the Pituitary-Adrenal Axis , J. Invest. Dermat. 22:25-31 ( (Jan.) ) 1954. 17. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in The White Rat. III. Evidence for the Presence of a Pituitary Sebaceous Gland Tropic Factor , J. Invest. Dermat. 24:499-505 ( (May) ) 1955. 18. Hambrick, G. W., Jr. and Blank, H.: A Microanalytical Study of the Response of the Pilosebaceous Apparatus of the Rabbit's Ear Canal , J. Invest. Dermat. 26:185-200 ( (March) ) 1956. 19. Hooker, C. W., and Pfeiffer, C. A.: Effects of Sex Hormones upon Body Growth, Skin, Hair and Sebaceous Glands in the Rat , Endocrinology 32:69-76 ( (Jan.) ) 1943. 20. Reiss, F., and Gellis, S.: Effects Produced on the Pilosebaceous System and the Adrenals of the Rabbit by Inunction of Sex Hormones , J. Invest. Dermat. 12:159-172 ( (March) ) 1949. 21. Way, S. C., and Andrews, G. C.: Hormones and Acne: A Clinical Evaluation of Hormonal Therapy in Adolescent Girls with Acne , Arch. Dermat. & Syph. 61:575-588 ( (April) ) 1950. 22. Andrews, G. C.; Domonkos, A. N., and Post, C. F.: Treatment of Acne Vulgaris , J. A. M. A. 146:1107-1113 ( (July 21) ) 1951. 23. Johnson, O. R.: Treatment of Acne in the Female with a Hormone , J. Maine M. A. 42:258 ( (Aug.) ) 1951. 24. Newman, B. A., and Feldman, F. F.: Adult Premenstrual Acne , A. M. A. Arch. Dermat. & Syph. 69:356-363 ( (March) ) 1954. 25. Lewis, H. M.; Frumess, G. M., and Henschel, E. J.: Progesterone Therapy of Acne: A Clinical Evaluation , A. M. A. Arch. Dermat. & Syph. 64:562-564 ( (Nov.) ) 1951. 26. Miescher, G. and Schönberg, A.: Untersuchungen über die Funktion der Talgdrüsen , Bull. schweiz. Akad. med. Wissensch. 1:101-114, 1944. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Experimental Production of Acne by Progesterone

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550230118017
Publisher site
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Abstract

Abstract There is general recognition today that there may be many factors in the etiology of acne vulgaris. Thus there are hereditary, nutritional, climatic, emotional, bacterial, and, particularly, endocrinal influences. Sebaceous glands, relatively small during childhood, start to grow rapidly with the onset of puberty. At the same time there is a considerable increase in the amount of sebum excreted to the skin surface. This sebaceous hyperfunction is the cause of seborrhea in adolescence and is considered to be a major component of acne vulgaris.1 In males the role of testicular androgens in sebaceous hyperfunction has long been recognized.2 In females, adrenal androgens have been held responsible for pubertal seborrhea, but recent studies have called attention to the part played here by another hormone. Progesterone, the active principle produced by the corpus luteum, has been shown to have the same effects as testosterone in causing References 1. Courtesy, Schering Corporation, Bloomfield, N. J., which supplied Proluton 50 mg/cc. 2. Margaret Merrell, Sc.D., Department of Biostatistics, School of Hygiene and Public Health, The Johns Hopkins University: Personal communication to the authors. 3. Rothman, S.: Physiology and Pathology of Sebaceous Gland Secretion , Tr. St. Johns' Hospital Dermat. Soc. 33:1-6 ( (Oct.) ) 1954. 4. Hamilton, J. B.: Male Hormone Substance: A Prime Factor in Acne , J. Clin. Endocrinol. 1:570-592 ( (July) ) 1941.Crossref 5. Haskin, D.; Lasher, N., and Rothman, S.: Some Effects of ACTH, Cortisone, Progesterone and Testosterone on Sebaceous Glands in the White Rat , J. Invest. Dermat. 20:207-212 ( (March) ) 1953. 6. Malkinson, F. D.: Acne Vulgaris , J. A. M. A. 159:1117-1119 ( (Nov. 12) ) 1955.Crossref 7. Shelley, W. B., and Cahn, M. M.: Experimental Studies on the Effect of Hormones on the Human Skin with Reference to the Axillary Apocrine Sweat Gland , J. Invest. Dermat. 25:127-131 ( (Aug.) ) 1955.Crossref 8. Rony, H. R., and Zakon, S. J.: Effect of Androgen on the Sebaceous Glands of Human Skin , Arch. Dermat. & Syph. 48:601-604 ( (Dec.) ) 1943. 9. DeGraaf, H. J.: Endocrine Influences on Sebaceous Glands , Acta Brev. Neerl. 12:67-68, 1942. 10. Ebling, F. J.: Sebaceous Glands: 1. The Effect of Sex Hormones on the Sebaceous Glands of the Female Albino Rat , J. Endocrinol. 5:297-302 ( (June) ) 1948. 11. Hamilton, J. B., and Montagna, W.: The Sebaceous Glands of the Hamster: I. Morphological Effects of Androgens on Integumentary Structures , Am. J. Anat. 86:191-234, 1950. 12. Rothman, S.: Physiology and Biochemistry of the Skin , Chicago, University of Chicago Press, 1954. 13. Sullivan, M., and Zeligman, I.: Acneform Eruption Due to Corticotropin , A. M. A. Arch. Dermat. 73:133-141 ( (Feb.) ) 1956. 14. Baker, B. L.; Ingle, D. J.; Li, C. H., and Evans, H. M.: Growth Inhibition in the Skin Induced by Parenteral Administration of Adrenocorticotropin , Anat. Rec. 102:313-331 ( (Nov.) ) 1948. 15. Aron-Brunetière, R.: An Attempt at a Physiopathological Explanation of Seborrhea and Acne Vulgaris: Therapeutic Results , Brit. J. Dermat. 65:157-164 ( (May) ) 1953. 16. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in The White Rat: II. The Effect of the Pituitary-Adrenal Axis , J. Invest. Dermat. 22:25-31 ( (Jan.) ) 1954. 17. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in The White Rat. III. Evidence for the Presence of a Pituitary Sebaceous Gland Tropic Factor , J. Invest. Dermat. 24:499-505 ( (May) ) 1955. 18. Hambrick, G. W., Jr. and Blank, H.: A Microanalytical Study of the Response of the Pilosebaceous Apparatus of the Rabbit's Ear Canal , J. Invest. Dermat. 26:185-200 ( (March) ) 1956. 19. Hooker, C. W., and Pfeiffer, C. A.: Effects of Sex Hormones upon Body Growth, Skin, Hair and Sebaceous Glands in the Rat , Endocrinology 32:69-76 ( (Jan.) ) 1943. 20. Reiss, F., and Gellis, S.: Effects Produced on the Pilosebaceous System and the Adrenals of the Rabbit by Inunction of Sex Hormones , J. Invest. Dermat. 12:159-172 ( (March) ) 1949. 21. Way, S. C., and Andrews, G. C.: Hormones and Acne: A Clinical Evaluation of Hormonal Therapy in Adolescent Girls with Acne , Arch. Dermat. & Syph. 61:575-588 ( (April) ) 1950. 22. Andrews, G. C.; Domonkos, A. N., and Post, C. F.: Treatment of Acne Vulgaris , J. A. M. A. 146:1107-1113 ( (July 21) ) 1951. 23. Johnson, O. R.: Treatment of Acne in the Female with a Hormone , J. Maine M. A. 42:258 ( (Aug.) ) 1951. 24. Newman, B. A., and Feldman, F. F.: Adult Premenstrual Acne , A. M. A. Arch. Dermat. & Syph. 69:356-363 ( (March) ) 1954. 25. Lewis, H. M.; Frumess, G. M., and Henschel, E. J.: Progesterone Therapy of Acne: A Clinical Evaluation , A. M. A. Arch. Dermat. & Syph. 64:562-564 ( (Nov.) ) 1951. 26. Miescher, G. and Schönberg, A.: Untersuchungen über die Funktion der Talgdrüsen , Bull. schweiz. Akad. med. Wissensch. 1:101-114, 1944.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1957

References