Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

EXPERIMENTAL PHARMACOLOGY OF POSTENCEPHALITIC PARKINSON'S DISEASE

EXPERIMENTAL PHARMACOLOGY OF POSTENCEPHALITIC PARKINSON'S DISEASE Abstract Despite the wide use of drugs in the treatment of Parkinson's syndrome, there is on the whole a lack of specific and objective data with regard to their effect on the two outstanding symptoms of the disease, namely, rigidity and tremor. The object of the present study was (1) to compare the effects of the drugs commonly used in management of the disease with those of a number of relatively new drugs and (2) to attempt better to understand the site of action of these drugs. METHOD AND MATERIAL Many pharmacologic observations were made on a number of patients with Parkinson's syndrome showing varying degrees of rigidity and tremor. Of these, 2 were finally selected as the most suitable subjects for intensive and prolonged study.The first patient (S. I.), a woman aged 25, exhibited moderately marked rigidity of the right arm and leg, with mild tremor of these parts. References 1. Myerson, A.; Loman, J.; Rinkel, M., and Lesses, M. F.: Human Autonomic Pharmacology: XVIII. Effects of the Intra-Arterial Injection of Acetylcholine, Acetyl-Beta-Methylcholine Chloride, Epinephrine, and Benzedrine Sulfate , Am. Heart J. 16:329-335 ( (Sept.) ) 1938.Crossref 2. Paredrine was used in a concentration of 20 mg. per cubic centimeter of solution. 3. Morita, S.: Untersuchungen auf grosshirnlosen Kaninchen: III. Die Einwirkungen zentraler Erregungsmittel auf den Chloralschlal , Arch. f. exper. Path. u. Pharmakol. 78:218-222, 1915.Crossref 4. Rioch, D. M., and Brenner, C.: Experiments on Corpus Striatum and Rhinencephalon , J. Comp. Neurol. 68:491-507 ( (June) ) 1938.Crossref 5. Dusser de Barenne, J. G., and McCulloch, W. S.: Sensorimotor Cortex, Nucleus Caudatus and Thalamus Opticus , J. Neurophysiol. 1:364-377 ( (July) ) 1938 6. Suppression of Motor Response upon Stimulation of Area 4-F of the Cerebral Cortex , Am. J. Physiol. 126:P482 ( (July) ) 1939. 7. Mettler, F. A.; Ades, H. W.; Lipman, E., and Culler, E. A.: The Extrapyramidal System: An Extrapyramidal Demonstration of Function , Arch. Neurol. & Psychiat. 41:984-995 ( (May) ) 1939. 8. Klemme, R. M.: A. Research Nerv. & Ment. Dis., Proc. , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EXPERIMENTAL PHARMACOLOGY OF POSTENCEPHALITIC PARKINSON'S DISEASE

Loading next page...
 
/lp/american-medical-association/experimental-pharmacology-of-postencephalitic-parkinson-s-disease-w4GbYjFitO
Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290030057004
Publisher site
See Article on Publisher Site

Abstract

Abstract Despite the wide use of drugs in the treatment of Parkinson's syndrome, there is on the whole a lack of specific and objective data with regard to their effect on the two outstanding symptoms of the disease, namely, rigidity and tremor. The object of the present study was (1) to compare the effects of the drugs commonly used in management of the disease with those of a number of relatively new drugs and (2) to attempt better to understand the site of action of these drugs. METHOD AND MATERIAL Many pharmacologic observations were made on a number of patients with Parkinson's syndrome showing varying degrees of rigidity and tremor. Of these, 2 were finally selected as the most suitable subjects for intensive and prolonged study.The first patient (S. I.), a woman aged 25, exhibited moderately marked rigidity of the right arm and leg, with mild tremor of these parts. References 1. Myerson, A.; Loman, J.; Rinkel, M., and Lesses, M. F.: Human Autonomic Pharmacology: XVIII. Effects of the Intra-Arterial Injection of Acetylcholine, Acetyl-Beta-Methylcholine Chloride, Epinephrine, and Benzedrine Sulfate , Am. Heart J. 16:329-335 ( (Sept.) ) 1938.Crossref 2. Paredrine was used in a concentration of 20 mg. per cubic centimeter of solution. 3. Morita, S.: Untersuchungen auf grosshirnlosen Kaninchen: III. Die Einwirkungen zentraler Erregungsmittel auf den Chloralschlal , Arch. f. exper. Path. u. Pharmakol. 78:218-222, 1915.Crossref 4. Rioch, D. M., and Brenner, C.: Experiments on Corpus Striatum and Rhinencephalon , J. Comp. Neurol. 68:491-507 ( (June) ) 1938.Crossref 5. Dusser de Barenne, J. G., and McCulloch, W. S.: Sensorimotor Cortex, Nucleus Caudatus and Thalamus Opticus , J. Neurophysiol. 1:364-377 ( (July) ) 1938 6. Suppression of Motor Response upon Stimulation of Area 4-F of the Cerebral Cortex , Am. J. Physiol. 126:P482 ( (July) ) 1939. 7. Mettler, F. A.; Ades, H. W.; Lipman, E., and Culler, E. A.: The Extrapyramidal System: An Extrapyramidal Demonstration of Function , Arch. Neurol. & Psychiat. 41:984-995 ( (May) ) 1939. 8. Klemme, R. M.: A. Research Nerv. & Ment. Dis., Proc. , to be published.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1942

References