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EXPERIMENTAL PERIPHERAL GANGRENE: EFFECT OF ESTROGENIC SUBSTANCE AND ITS RELATION TO THROMBO-ANGIITIS OBLITERANS

EXPERIMENTAL PERIPHERAL GANGRENE: EFFECT OF ESTROGENIC SUBSTANCE AND ITS RELATION TO... Abstract The present studies have their genesis in an effort to open a new avenue of approach to the problem of thrombo-angiitis obliterans. Perusal of the literature adequately demonstrates the confusion surrounding the clinical and experimental aspects of this disturbance. What knowledge one has concerning the malady has been gleaned from purely clinical and statistical research. Experimental investigation,1 directed almost exclusively toward establishing a specific bacterial etiologic agent for the disease, has thus far either failed completely or the results have been so meager as to be altogether inconclusive. It would appear rather facetious to state that in an endeavor to reproduce experimentally a pathologic entity one must first know the pathology. Nevertheless it is here that the first difficulty is encountered. There is no unanimity of opinion among students of the disease regarding the pathology of thrombo-angiitis obliterans. Buerger,2 in his descriptions of the pathogenicity and chronologic pathology, References 1. Rabinowitz, H. M.: Experiments on the Infectious Origin of Thrombo-Angiitis Obliterans and the Isolation of a Specific Organism from the Blood Stream , Surg., Gynec. & Obst. 37:353, 1923. 2. Buerger, Leo: Thrombo-Angiitis Obliterans: Experimental Reproduction of Lesions , Arch. Path. 7:381 ( (March) ) 1929. 3. Horton, B. T., and Dorsey, A. H. E.: Experimental Thrombo-Angiitis Obliterans: Bacteriologic and Pathologic Studies , Arch. Path. 13:910 ( (June) ) 1932. 4. Buerger, Leo: Thrombo-Angiitis Obliterans: A Study of the Vascular Lesions Leading to Presenile Spontaneous Gangrene , Am. J. M. Sc. 136:567, 1908 5. Is Thrombo-Angiitis Obliterans an Infectious Disease? Surg., Gynec. & Obst. 19:582, 1914 6. The Circulatory Disturbances of the Extremities , Philadelphia, W. B. Saunders Company, 1924. 7. Mahorner, H. R., in Brown, G. E.; Allen, E. V., and Mahorner, H. R.: Thrombo-Angiitis Obliterans , Mayo Clinic Monograph, Philadelphia, W. B. Saunders Company, 1928. 8. Telford, E. D., and Stopford, J. S. B.: Thrombo-Angiitis Obliterans , Brit. M. J. 2:1035, 1924. 9. Schmidt-Weyland ( Klin. Wchnschr. 11:2148, 1932). 10. Kaunitz, J.: The Pathologic Similarity of Thrombo-Angiitis Obliterans and Endemic Ergotism , Am. J. Path. 6:299, 1930 11. Chronic Endemic Ergotism: Its Relation to the Vasomotor and Trophic Diseases , Arch. Int. Med. 47:548 ( (April) ) 1931 12. Chronic Endemic Ergotism: Its Relation to Thrombo-Angiitis Obliterans , Arch. Surg. 25:1135 ( (Dec.) ) 1932. 13. Rothlin, E.: Recherches expérimentales sur l'ergotamine, alcalöide spécifique de l'ergot de Seigle , Arch. internat. de pharmacodyn. et de thérap. 27:459, 1923. 14. Polak, E.: Experiments on Ergotism , Časop. lék. ćesk. 63:1409, 1924. 15. The gynergen, sandoz, and theelin, Parke, Davis and Co., used in these studies were the standard products, purchased in the open market. 16. Meyer, W.: Etiology of Thrombo-Angiitis Obliterans , J. A. M. A. 71: 1268 ( (Oct. 19) ) 1918 17. A Further Contribution to the Etiology of Thrombo-Angiitis Obliterans , M. Rec. 97:425, 1920. 18. Silbert, S.: Studies on Thrombo-Angiitis Obliterans (Buerger): II. The Effectiveness of Therapeutic Procedures , J. A. M. A. 89:964 ( (Sept. 17) ) 1927. 19. Samuels, S. S.: Gangrene Due to Thrombo-Angiitis Obliterans: Further Experiences with Treatment , J. A. M. A. 102:436 ( (Feb. 10) ) 1934. 20. Barker, N. W.: The Tobacco Factor in Thrombo-Angiitis Obliterans , Proc. Staff Meet., Mayo Clin. 6:65, 1931 21. Vasoconstrictor Effects of Tobacco Smoking , Proc. Staff Meet., Mayo Clin. 8:284, 1933. 22. Maddock, W. G., and Coller, F. A.: Peripheral Vasoconstriction by Tobacco and Its Relation to Thrombo-Angiitis Obliterans , Ann. Surg. 97:70, 1933. 23. Harkevy, J.; Hebald, S., and Silbert, S.: Tobacco Sensitiveness in Thrombo-Angiitis Obliterans , Proc. Soc. Exper. Biol. & Med. 30:104, 1932. 24. Sulzberger, M. B.; Scholder, B., and Feit, E.: Studies in Tobacco Hypersensitivity , J. Immunol. 24:85, 1933. 25. Wwedensky, A. A.: Ueber Arteritis Obliterans und ihre Folgen , Arch. f. klin. Chir. 57:98, 1898. 26. Meleny, F. L., and Miller, G. G.: A Contribution to the Study of Thrombo-Angiitis Obliterans , Ann. Surg. 81:976, 1925.Crossref 27. Telford, E. D., and Stopford, J. S. B.: Two Cases of Thrombo-Angiitis Obliterans in Women , Brit. M. J. 1:1140, 1927.Crossref 28. Trabaud, J., and Mredden, I.: Maladie de Léo Buerger chez une jeune fille musulmane , Bull. et mém. Soc. méd. d. hôp. de Paris 47:579, 1931. 29. Horton, B. T., and Brown, G. E.: Thrombo-Angiitis Obliterans Among Women , Arch. Int. Med. 50:884 ( (Dec.) ) 1932.Crossref 30. Chi square for the females of the four series, contrasting the results in those receiving ergotamine alone with the results in those receiving both ergotamine and theelin, on the basis of the development of gangrene of the tail, was 72.380925, the interpolation of which indicates that the possibility that these results were due to the operation of chance alone is less than 1 in 400,000,000,000. 31. Cushny, A. R.: A Textbook of Pharmacology and Therapeutics , ed. 9, Philadelphia, Lea & Febiger, 1928, p. 400. 32. Dale, H. H.: On Some Physiologic Actions of Ergot , J. Physiol. 34:163, 1906. 33. Mendez, R.: Antagonism of Adrenalin by Ergotamine , J. Pharmacol. & Exper. Therap. 32:451, 1928. 34. Bastido, W. A.: Materia Medica , ed. 3, Philadelphia, W. B. Saunders Company, 1933, p. 657. 35. Solis-Cohen, S., and Githens, T. S.: Pharmacotherapeutics , New York, D. Appleton & Company, 1928, p. 1768. 36. Rothlin, E.: Specific Action of Ergot Alkaloids on the Sympathetic Nervous System , J. Pharmacol. & Exper. Therap. 36:657, 1929. 37. Heymans, C., and Regniers, P.: Sur l'action vasculaire et sympathétique de l'ergotamine et de l'ergotinine , Arch. internat. de pharmacodyn. et de thérap. 33:236, 1927. 38. Ganter, G.: Ueber die Ausschaltung des vegetativen Nervensystems am Kreislauf , Arch. f. exper. Path. u. Pharmakol. 113:129, 1926. 39. Alvarez, W. C., and Zimmermann, A.: Blood Pressure in Women as Influenced by the Sexual Organs , Arch. Int. Med. 37:597 ( (May) ) 1926. 40. Daniel, C.; Crainicianu, A., and Mavromati, L.: Recherches cliniques des effets de la folliculine sur la pression artérielle chez l'homme , Compt. rend. Soc. de biol. 106:997, 1931. 41. Crainicianu, A.: Les effets vasculaires de la folliculine , J. de physiol. et de path. gén. 30:305, 1932. 42. Aymen, D.: The Treatment of Arteriolar Hypertension with Crystalline Ovarian Hormone (Theelin) , Am. J. M. Sc. 187:806 ( (June) ) 1934. 43. Baecke, L.: Un cas de maladie de Léo Buerger (thrombo-angéite oblitérante) traité par l'opothérapie ovarienne , Burxelles-m éd. 7:1086, 1927. 44. Sicard, M.: Sur la maladie de Buerger , Bull. et mém. Soc. méd. d. hôp. de Paris 51:443, 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EXPERIMENTAL PERIPHERAL GANGRENE: EFFECT OF ESTROGENIC SUBSTANCE AND ITS RELATION TO THROMBO-ANGIITIS OBLITERANS

Archives of Internal Medicine , Volume 55 (6) – Jun 1, 1935

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American Medical Association
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Copyright © 1935 American Medical Association. All Rights Reserved.
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0730-188X
DOI
10.1001/archinte.1935.00160240071004
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Abstract

Abstract The present studies have their genesis in an effort to open a new avenue of approach to the problem of thrombo-angiitis obliterans. Perusal of the literature adequately demonstrates the confusion surrounding the clinical and experimental aspects of this disturbance. What knowledge one has concerning the malady has been gleaned from purely clinical and statistical research. Experimental investigation,1 directed almost exclusively toward establishing a specific bacterial etiologic agent for the disease, has thus far either failed completely or the results have been so meager as to be altogether inconclusive. It would appear rather facetious to state that in an endeavor to reproduce experimentally a pathologic entity one must first know the pathology. Nevertheless it is here that the first difficulty is encountered. There is no unanimity of opinion among students of the disease regarding the pathology of thrombo-angiitis obliterans. Buerger,2 in his descriptions of the pathogenicity and chronologic pathology, References 1. Rabinowitz, H. M.: Experiments on the Infectious Origin of Thrombo-Angiitis Obliterans and the Isolation of a Specific Organism from the Blood Stream , Surg., Gynec. & Obst. 37:353, 1923. 2. Buerger, Leo: Thrombo-Angiitis Obliterans: Experimental Reproduction of Lesions , Arch. Path. 7:381 ( (March) ) 1929. 3. Horton, B. T., and Dorsey, A. H. E.: Experimental Thrombo-Angiitis Obliterans: Bacteriologic and Pathologic Studies , Arch. Path. 13:910 ( (June) ) 1932. 4. Buerger, Leo: Thrombo-Angiitis Obliterans: A Study of the Vascular Lesions Leading to Presenile Spontaneous Gangrene , Am. J. M. Sc. 136:567, 1908 5. Is Thrombo-Angiitis Obliterans an Infectious Disease? Surg., Gynec. & Obst. 19:582, 1914 6. The Circulatory Disturbances of the Extremities , Philadelphia, W. B. Saunders Company, 1924. 7. Mahorner, H. R., in Brown, G. E.; Allen, E. V., and Mahorner, H. R.: Thrombo-Angiitis Obliterans , Mayo Clinic Monograph, Philadelphia, W. B. Saunders Company, 1928. 8. Telford, E. D., and Stopford, J. S. B.: Thrombo-Angiitis Obliterans , Brit. M. J. 2:1035, 1924. 9. Schmidt-Weyland ( Klin. Wchnschr. 11:2148, 1932). 10. Kaunitz, J.: The Pathologic Similarity of Thrombo-Angiitis Obliterans and Endemic Ergotism , Am. J. Path. 6:299, 1930 11. Chronic Endemic Ergotism: Its Relation to the Vasomotor and Trophic Diseases , Arch. Int. Med. 47:548 ( (April) ) 1931 12. Chronic Endemic Ergotism: Its Relation to Thrombo-Angiitis Obliterans , Arch. Surg. 25:1135 ( (Dec.) ) 1932. 13. Rothlin, E.: Recherches expérimentales sur l'ergotamine, alcalöide spécifique de l'ergot de Seigle , Arch. internat. de pharmacodyn. et de thérap. 27:459, 1923. 14. Polak, E.: Experiments on Ergotism , Časop. lék. ćesk. 63:1409, 1924. 15. The gynergen, sandoz, and theelin, Parke, Davis and Co., used in these studies were the standard products, purchased in the open market. 16. Meyer, W.: Etiology of Thrombo-Angiitis Obliterans , J. A. M. A. 71: 1268 ( (Oct. 19) ) 1918 17. A Further Contribution to the Etiology of Thrombo-Angiitis Obliterans , M. Rec. 97:425, 1920. 18. Silbert, S.: Studies on Thrombo-Angiitis Obliterans (Buerger): II. The Effectiveness of Therapeutic Procedures , J. A. M. A. 89:964 ( (Sept. 17) ) 1927. 19. Samuels, S. S.: Gangrene Due to Thrombo-Angiitis Obliterans: Further Experiences with Treatment , J. A. M. A. 102:436 ( (Feb. 10) ) 1934. 20. Barker, N. W.: The Tobacco Factor in Thrombo-Angiitis Obliterans , Proc. Staff Meet., Mayo Clin. 6:65, 1931 21. Vasoconstrictor Effects of Tobacco Smoking , Proc. Staff Meet., Mayo Clin. 8:284, 1933. 22. Maddock, W. G., and Coller, F. A.: Peripheral Vasoconstriction by Tobacco and Its Relation to Thrombo-Angiitis Obliterans , Ann. Surg. 97:70, 1933. 23. Harkevy, J.; Hebald, S., and Silbert, S.: Tobacco Sensitiveness in Thrombo-Angiitis Obliterans , Proc. Soc. Exper. Biol. & Med. 30:104, 1932. 24. Sulzberger, M. B.; Scholder, B., and Feit, E.: Studies in Tobacco Hypersensitivity , J. Immunol. 24:85, 1933. 25. Wwedensky, A. A.: Ueber Arteritis Obliterans und ihre Folgen , Arch. f. klin. Chir. 57:98, 1898. 26. Meleny, F. L., and Miller, G. G.: A Contribution to the Study of Thrombo-Angiitis Obliterans , Ann. Surg. 81:976, 1925.Crossref 27. Telford, E. D., and Stopford, J. S. B.: Two Cases of Thrombo-Angiitis Obliterans in Women , Brit. M. J. 1:1140, 1927.Crossref 28. Trabaud, J., and Mredden, I.: Maladie de Léo Buerger chez une jeune fille musulmane , Bull. et mém. Soc. méd. d. hôp. de Paris 47:579, 1931. 29. Horton, B. T., and Brown, G. E.: Thrombo-Angiitis Obliterans Among Women , Arch. Int. Med. 50:884 ( (Dec.) ) 1932.Crossref 30. Chi square for the females of the four series, contrasting the results in those receiving ergotamine alone with the results in those receiving both ergotamine and theelin, on the basis of the development of gangrene of the tail, was 72.380925, the interpolation of which indicates that the possibility that these results were due to the operation of chance alone is less than 1 in 400,000,000,000. 31. Cushny, A. R.: A Textbook of Pharmacology and Therapeutics , ed. 9, Philadelphia, Lea & Febiger, 1928, p. 400. 32. Dale, H. H.: On Some Physiologic Actions of Ergot , J. Physiol. 34:163, 1906. 33. Mendez, R.: Antagonism of Adrenalin by Ergotamine , J. Pharmacol. & Exper. Therap. 32:451, 1928. 34. Bastido, W. A.: Materia Medica , ed. 3, Philadelphia, W. B. Saunders Company, 1933, p. 657. 35. Solis-Cohen, S., and Githens, T. S.: Pharmacotherapeutics , New York, D. Appleton & Company, 1928, p. 1768. 36. Rothlin, E.: Specific Action of Ergot Alkaloids on the Sympathetic Nervous System , J. Pharmacol. & Exper. Therap. 36:657, 1929. 37. Heymans, C., and Regniers, P.: Sur l'action vasculaire et sympathétique de l'ergotamine et de l'ergotinine , Arch. internat. de pharmacodyn. et de thérap. 33:236, 1927. 38. Ganter, G.: Ueber die Ausschaltung des vegetativen Nervensystems am Kreislauf , Arch. f. exper. Path. u. Pharmakol. 113:129, 1926. 39. Alvarez, W. C., and Zimmermann, A.: Blood Pressure in Women as Influenced by the Sexual Organs , Arch. Int. Med. 37:597 ( (May) ) 1926. 40. Daniel, C.; Crainicianu, A., and Mavromati, L.: Recherches cliniques des effets de la folliculine sur la pression artérielle chez l'homme , Compt. rend. Soc. de biol. 106:997, 1931. 41. Crainicianu, A.: Les effets vasculaires de la folliculine , J. de physiol. et de path. gén. 30:305, 1932. 42. Aymen, D.: The Treatment of Arteriolar Hypertension with Crystalline Ovarian Hormone (Theelin) , Am. J. M. Sc. 187:806 ( (June) ) 1934. 43. Baecke, L.: Un cas de maladie de Léo Buerger (thrombo-angéite oblitérante) traité par l'opothérapie ovarienne , Burxelles-m éd. 7:1086, 1927. 44. Sicard, M.: Sur la maladie de Buerger , Bull. et mém. Soc. méd. d. hôp. de Paris 51:443, 1927.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1935

References