Abstract In an earlier study dealing with the effect of α-chymotrypsin on the electroretinogram of monkeys, severe pathological cupping of the optic disc and atrophy of the optic nerve were noted in routine histological sections (Hamasaki and Ellerman).1 These changes were associated with a rise in the intraocular pressure, abolition of the ERG, and damage to the retina. The cupping occurred within seven days after the injection of as little as 75 units of the enzyme. The rise in intraocular pressure confirmed the extensive and well-controlled clinical observations of Kirsch2 who reported a significant increase in the incidence of transient glaucoma following the use of α-chymotrypsin during cataract surgery. The present report is concerned with the optic nerve changes associated with an elevation of intraocular pressure induced by the injection of α-chymotrypsin, talcum powder, and dental molding cement into the eye of monkeys. Part I describes the relationship between References 1. Hamasaki, D.I., and Ellerman, N.: Abolition of the Electroretinogram Following Injection of α-Chymotrypsin Into the Vitreous and Anterior Chamber of Monkey , Arch Ophthal 73:843-850, 1965.Crossref 2. Kirsch, R.E.: Use of α-Chymotrypsin in Cataract Extraction Followed by Transient Glaucoma , Arch Ophthal 72:612-620, 1964.Crossref 3. Kalvin, N.; Hamasaki, D.I.; and Gass, J.D.: Experimental Glaucomatous Cupping and Ischemic Optic Neuropathy in Primates, Presented at the 24th Wilmer Residents Association Meeting, Wilmer Ophthalmologic Institute, Baltimore, 1965. 4. Voronina, E.C.: Production of Experimental Glaucoma and Its Clinical Aspects , Biull Eksp Biol Med 37:30-32, 1954. 5. Skotnicki, H.: Experimental Glaucoma , Klin Oczna 27:27-36, 1957. 6. Flocks, M.; Tsukahara, M.D.; and Miller, J.: Mechanically Induced Glaucoma in Animals , Amer J Ophthal 48:11-18, 1959. 7. Kupfer, C.: Studies of Intraocular Pressure: II. The Histopathology of Experimentally Increased Intraocular Pressure in the Rabbit , Invest Ophthal 1:474-479, 1962. 8. Samis, W.D.: An Experimental Method to Produce Angle Block in Rabbits and the Use of Phospholine Iodide After Angle Block , Amer J Ophthal 54:1089-1091, 1962. 9. Kazdan, J.J.: Experimental Angle Block Avoiding Paracentesis Reflex , Amer J Ophthal 56:836, 1964. 10. Huggert, A.: Obstruction of the Outflow of Aqueous Humor Produced Experimentally , Acta Ophthal 35:1-10, 1957.Crossref 11. de Carvalho, C.A.: Histopathology of Retina and Optic Nerve With Experimental Glaucoma , Arch Ophthal 67:483-487, 1962.Crossref 12. Smith, J.L., et al: The Fundus Oculi in the Squirrel, Owl and Marmoset Monkey: A Study With Fluorescein Angiography , Amer J Ophthal 57:431-435, 1964. 13. Radnót, M., and Pajor, R.: Histological Investigations on Effect Exerted by Alpha-Chymotrypsin on the Retina , Acta Ophthal 38:583-586, 1960.Crossref 14. O'Malley, C.; Moskovitz, M.; and Straatsma, B.R.: Experimentally Induced Adverse Effects of Alpha-Chymotrypsin , Arch Ophthal 66:539-544, 1961.Crossref 15. Hogan, M.J., and Zimmerman, L.E.: Ophthalmic Pathology , ed 2, Philadelphia: W. B. Saunders Co., 1962. 16. Wolff, E.: Schnabel's Cavernous Atrophy , Trans Ophthal Soc UK 68:133-139, 1947.
Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1966
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