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Experimental Double-Perforating Injury of the Posterior Segment in Rabbit Eyes: The Natural History of Intraocular Proliferation

Experimental Double-Perforating Injury of the Posterior Segment in Rabbit Eyes: The Natural... Abstract • A reproducible model of double perforating injury of the posterior segment of the rabbit eye was developed. Immediately after injury, a vitreous condensation was visible between wounds. The scleral exit wound was sealed by fibroblastic proliferation of probable episcleral origin by the fourth day and the entrance similarly by the seventh day. Cellular proliferations originating in the wounds crossed the vitreous cavity following the vitreous injury tract or condensed vitreous to the disc or to the vitreous base. The earliest intraocular proliferations, composed of spindle-shaped, fibroblast-like cells, were seen at day 4. Occasional pigment epithelia were present in and on these proliferations. Other proliferations occurred directly on the retinal surface adjacent to the wounds. The transvitreous proliferations employed the vitreous as a scaffold, while the surface proliferations used the retinal surface for contact guidance. References 1. Edmund J: The prognosis of perforating eye injuries . Acta Ophthalmol 46:1165-1174, 1968.Crossref 2. Johnston S: Perforating eye injuries: A five year study . Trans Ophthalmol Soc UK 91:895-921, 1971. 3. Coles WH, Haik GM: Vitrectomy in intraocular trauma . Arch Ophthalmol 87:621-628, 1972.Crossref 4. Jensen OA: Enucleated injured eyes in Denmark 1958-1967 . Acta Ophthalmol 46:1194-1206, 1968.Crossref 5. Benson WE, Machemer R: Severe perforating injuries treated with pars plana vitrectomy . Am J Ophthalmol 81:728-732, 1976. 6. Hutton WL, Snyder WB, Vaiser A: Vitrectomy in the treatment of ocular perforating injuries . Am J Ophthalmol 81:733-739, 1976. 7. Peacock EE, Van Winkle W Jr: Wound Repair , ed 2. Philadelphia, WB Saunders Co, 1976. 8. Frayer W: Reactivity of retinal pigment epithelium: An experimental and histopathologic study . Trans Am Ophthalmol Soc 64:586-643, 1966. 9. Laqua H, Machemer R: Repair and adhesion mechanisms of the cryotherapy lesion in experimental retinal detachment . Am J Ophthalmol 81:833-846, 1976. 10. Wallow IHL, Tso MOM: Repair after xenon arc photocoagulation: II. A clinical and light microscopic study of the evolution of retinal lesions in the rhesus monkey . Am J Ophthalmol 75:610-626, 1973. 11. Powell JO, Bresnick GH, Yanoff M: Ocular effects of argon laser radiation: Histopathology of chorioretinal lesions . Am J Ophthalmol 71:1267-1276, 1971. 12. Machemer R, van Horn D, Aaberg T: Pigment epithelial proliferation in human retinal detachment with massive periretinal proliferation . Am J Ophthalmol 85:181-191, 1978. 13. Mandelcorn MS, Machemer R, Feinberg E, et al: Proliferation and metaplasia of intravitreal retinal pigment epithelium cell autotransplants . Am J Ophthalmol 80:227-237, 1975. 14. Mueller-Jensen K, Machemer R, Azarnia R: Autotransplantation of retinal pigment epithelium in intravitreal diffusion chambers . Am J Ophthalmol 80:530-537, 1975. 15. Newsome DA, Kenyon KR: Collagen production in vitro by the retinal pigmented epithelium of the chick embryo . Dev Biol 32:387-400, 1973.Crossref 16. Sipperley J, Quigley HA, Gass JDM: The experimental histology of traumatic retinopathy in primates: The explanation of commotio retinae. Presented at Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 25, 1977. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Experimental Double-Perforating Injury of the Posterior Segment in Rabbit Eyes: The Natural History of Intraocular Proliferation

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1979.01020010387024
Publisher site
See Article on Publisher Site

Abstract

Abstract • A reproducible model of double perforating injury of the posterior segment of the rabbit eye was developed. Immediately after injury, a vitreous condensation was visible between wounds. The scleral exit wound was sealed by fibroblastic proliferation of probable episcleral origin by the fourth day and the entrance similarly by the seventh day. Cellular proliferations originating in the wounds crossed the vitreous cavity following the vitreous injury tract or condensed vitreous to the disc or to the vitreous base. The earliest intraocular proliferations, composed of spindle-shaped, fibroblast-like cells, were seen at day 4. Occasional pigment epithelia were present in and on these proliferations. Other proliferations occurred directly on the retinal surface adjacent to the wounds. The transvitreous proliferations employed the vitreous as a scaffold, while the surface proliferations used the retinal surface for contact guidance. References 1. Edmund J: The prognosis of perforating eye injuries . Acta Ophthalmol 46:1165-1174, 1968.Crossref 2. Johnston S: Perforating eye injuries: A five year study . Trans Ophthalmol Soc UK 91:895-921, 1971. 3. Coles WH, Haik GM: Vitrectomy in intraocular trauma . Arch Ophthalmol 87:621-628, 1972.Crossref 4. Jensen OA: Enucleated injured eyes in Denmark 1958-1967 . Acta Ophthalmol 46:1194-1206, 1968.Crossref 5. Benson WE, Machemer R: Severe perforating injuries treated with pars plana vitrectomy . Am J Ophthalmol 81:728-732, 1976. 6. Hutton WL, Snyder WB, Vaiser A: Vitrectomy in the treatment of ocular perforating injuries . Am J Ophthalmol 81:733-739, 1976. 7. Peacock EE, Van Winkle W Jr: Wound Repair , ed 2. Philadelphia, WB Saunders Co, 1976. 8. Frayer W: Reactivity of retinal pigment epithelium: An experimental and histopathologic study . Trans Am Ophthalmol Soc 64:586-643, 1966. 9. Laqua H, Machemer R: Repair and adhesion mechanisms of the cryotherapy lesion in experimental retinal detachment . Am J Ophthalmol 81:833-846, 1976. 10. Wallow IHL, Tso MOM: Repair after xenon arc photocoagulation: II. A clinical and light microscopic study of the evolution of retinal lesions in the rhesus monkey . Am J Ophthalmol 75:610-626, 1973. 11. Powell JO, Bresnick GH, Yanoff M: Ocular effects of argon laser radiation: Histopathology of chorioretinal lesions . Am J Ophthalmol 71:1267-1276, 1971. 12. Machemer R, van Horn D, Aaberg T: Pigment epithelial proliferation in human retinal detachment with massive periretinal proliferation . Am J Ophthalmol 85:181-191, 1978. 13. Mandelcorn MS, Machemer R, Feinberg E, et al: Proliferation and metaplasia of intravitreal retinal pigment epithelium cell autotransplants . Am J Ophthalmol 80:227-237, 1975. 14. Mueller-Jensen K, Machemer R, Azarnia R: Autotransplantation of retinal pigment epithelium in intravitreal diffusion chambers . Am J Ophthalmol 80:530-537, 1975. 15. Newsome DA, Kenyon KR: Collagen production in vitro by the retinal pigmented epithelium of the chick embryo . Dev Biol 32:387-400, 1973.Crossref 16. Sipperley J, Quigley HA, Gass JDM: The experimental histology of traumatic retinopathy in primates: The explanation of commotio retinae. Presented at Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 25, 1977.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1979

References