Abstract Introduction Investigations of the pathogenesis and treatment of diabetic retinopathy have been handicapped by the lack of an acceptable model of the retinopathy in animals made diabetic experimentally. Although various retinal disorders have been reported in such animals, the lesions have remained unconfirmed or of uncertain relationship to the retinopathy of human diabetes. Retinal capillary aneurysms have been clearly demonstrated by Patz and Maumenee1 in a spontaneously diabetic dog, and recently by Hausler and coworkers2 in an experimentally diabetic dog having a complex history. Their work has established that man is not uniquely susceptible to the retinopathy, but whether the lesions are a result of diabetes, or of some genetic or other disorder attending diabetes has not been clarified. In the following study, retinopathy comparable to that of diabetes in man has been found to develop in three dogs as a result of either alloxan or metasomatotropin diabetes. References 1. Bovine somatotropin (Armour) supplied by Endocrine Study Section, National Institutes of Health; potency 106±15.9% of Armour Standard, 1957. 2. Ames Co., Inc., Elkhart, Ind. 3. Ames Co., Inc. 4. Patz, A., and Maumenee, A. E.: Studies on Diabetic Retinopathy, I. Retinopathy in Dog With Spontaneous Diabetes Mellitus , Amer J Ophthal 54:532-541, 1962. 5. Hausler, H. R.; Sibay, T. M.; and Campbell, J.: Retinopathy in Dog Following Diabetes Induced by Growth Hormone , Diabetes 13:122-126, 1964. 6. Engerman, R., and Bloodworth, J. M. B., Jr.: Experimental Diabetic Retinopathy, Read before Midwestern Section, Assn Res Ophthal, April, 1964, to be published in Invest Ophthal. 7. Hawk, P. B.; Oser, B. L.; and Summerson, W. H.: Practical Physiological Chemistry , ed 13, New York: Blakiston Co. (Division of McGrawHill Book Co.), 1954, p 929. 8. Kuwabara, T., and Cogan, D. G.: Studies of Retinal Vascular Patterns, I. Normal Architecture , Arch Ophthal 64:904-911, 1960.Crossref 9. Engerman, R.; Buesseler, J. A.; and Meyer, R. K.: Periodic Acid-Schiff Staining of Retinal Whole Mounts , Arch Ophthal 68:62-65, 1962.Crossref 10. Cogan, D. G.; Toussaint, D.; and Kuwabara, T.: Retinal Vascular Patterns, IV. Diabetic Retinopathy , Arch Ophthal 66:366-378, 1961.Crossref 11. Ashton, N.: Studies of the Retinal Capillaries in Relation to Diabetic and Other Retinopathies , Brit J Ophthal 47:521-537, 1963.Crossref 12. Toussaint, D.; Cogan, D. G.; and Kuwabara, T.: Extravascular Lesions of Diabetic Retinopathy , Arch Ophthal 67:42-47, 1962.Crossref 13. Bloodworth, J. M. B., Jr.: Experimental Diabetic Glomerulosclerosis, II, The Dog, Arch Path, to be published. 14. Miller, M.: " Diabetes Associated with Acromegaly, Hyperadrenocorticism, Hemochromatosis, Pancreatitis, Pancreatectomy, and Cancer ," in Diabetes , R. H. Williams, ed., New York: Hoeber, (Med Div Harper & Rowe) 1960, p 708-722. 15. Burton, T. Y.; Kearns, T. P.; and Rynearson, E. H.: Diabetic Retinopathy Following Total Pancreatectomy , Proc Mayo Clinic 32:735-739, 1957. 16. Marble, A., and Steinke, J.: Hämochromatose, Bericht über 42 Fälle mit Diabetes , Medizinische 1:19-23, 1959.
Archives of Ophthalmology – American Medical Association
Published: Feb 1, 1965