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EXPERIMENTAL DIABETES.

EXPERIMENTAL DIABETES. MM. Germain SEE and E. Gley have recently made a report on this subject to the Académie des Sciences. Thus far all attempts to produce diabetes in animals have failed—at least such forms of diabetes as are seen in the human subject. It is well known that irritation of the central end of the vagus nerve gives rise to hyperglycæmia and glycosuria. The experimenters have succeeded in producing permanent irritation of the central end of the right pneumogastric in dogs, and several of the animals have presented not only glycosuria, but true azoturia with notable and rapid emaciation. But this is only one of the elements of diabetes. Dogs have been made glycosuric also by being given daily a quantity of phloridzin. After the first day the urine of these dogs contained, for twenty-four hours, from 10 to 12 per cent, of glucose. The glycosuria ceased with the stoppage of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

EXPERIMENTAL DIABETES.

JAMA , Volume XII (8) – Feb 23, 1889

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Publisher
American Medical Association
Copyright
Copyright © 1889 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1889.02400850021005
Publisher site
See Article on Publisher Site

Abstract

MM. Germain SEE and E. Gley have recently made a report on this subject to the Académie des Sciences. Thus far all attempts to produce diabetes in animals have failed—at least such forms of diabetes as are seen in the human subject. It is well known that irritation of the central end of the vagus nerve gives rise to hyperglycæmia and glycosuria. The experimenters have succeeded in producing permanent irritation of the central end of the right pneumogastric in dogs, and several of the animals have presented not only glycosuria, but true azoturia with notable and rapid emaciation. But this is only one of the elements of diabetes. Dogs have been made glycosuric also by being given daily a quantity of phloridzin. After the first day the urine of these dogs contained, for twenty-four hours, from 10 to 12 per cent, of glucose. The glycosuria ceased with the stoppage of

Journal

JAMAAmerican Medical Association

Published: Feb 23, 1889

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