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EXPERIMENTAL CONCENTRIC AND ECCENTRIC CARDIAC HYPERTROPHY IN RATS

EXPERIMENTAL CONCENTRIC AND ECCENTRIC CARDIAC HYPERTROPHY IN RATS Abstract Chanutin (with Ferris1 and with Barksdale2) has recently shown that in rats deprived of 80 per cent of their renal tissue progressive renal lesions, arterial hypertension and cardiac hypertrophy develop. The width of the myocardial fibers of the right ventricle does not change, while the diameter of the fibers of the left ventricle bears "a substantial relationship" to the ratio of the weight of the heart to the surface area. The comparison of a unidimensional or bidimensional method of measurement with a volumetric method has in the past led to serious misinterpretation of data. In this instance there has been no error in conclusions, but the comparison of width of the fibers (a linear measurement) with the weight of the heart (proportional to the total volume of all the fibers) has concealed an important fact, namely, that when the fibers of the heart of the rat hypertrophy References 1. Chanutin, A., and Ferris, E. B.: Experimental Renal Insufficiency Produced by Partial Nephrectomy: I. Control Diet , Arch. Int. Med. 49:767 ( (May) ) 1932.Crossref 2. Chanutin, A., and Barksdale, E. E.: Experimental Renal Insufficiency Produced by Partial Nephrectomy: II. Relationship of Left Ventricular Hypertrophy, the Width of the Cardiac Muscle Fiber and Hypertension in the Rat , Arch. Int. Med. 52:739 ( (Nov.) ) 1933.Crossref 3. MacKay, L. L., and MacKay, E. M.: Factors Which Determine Renal Weight: I. Methods , Am. J. Physiol. 83:179 ( (Dec.) ) 1927. 4. Herrmann, G. R.: Experimental Heart Disease: I. Methods of Dividing Hearts, with Sectional and Proportional Weights and Ratios for Two Hundred Normal Dogs' Hearts , Am. Heart J. 1:213 ( (Dec.) ) 1925.Crossref 5. Krehl, L.: The Principles of Clinical Pathology , translated by A. W. Hewlett, ed. 2, Philadelphia, J. B. Lippincott Company, 1907, p. 60. 6. Fishberg, A. M.: Hypertension and Nephritis , ed. 2, Philadelphia, Lea & Febiger, 1931, p. 170. 7. Adami, J. G.: Notes upon Cardiac Hypertrophy , Montreal M. J. 23:811 ( (May) ) 1895. 8. Kaufmann, E.: Pathology for Students and Practitioners , translated by S. P. Reimann, Philadelphia, P. Blakiston's Son & Co., 1929, vol. 1, p. 73. 9. Mönckeberg, J. G.: Die Erkrankungen des Myokards und des spezifischen Muskelsystems , in Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1924, vol. 2, p. 350. 10. Dietlen, Hans: Herzgrösse, Herzmessmethoden 11. Anpassung, Hypertrophie. Dilatation, Tonus des Herzens, in Bethe, A. 12. Bergmann, G. 13. Embden, G., and Ellinger, A.: Handbuch der normalen und pathologischen Physiologic , Berlin. Julius Springer, 1926, vol. 7, p. 351. 14. Hales, Stephen: Statical Essays , London, W. Innys and others, 1733. 15. du Castel: Recherches sur l'hypertrophie et la dilatation des ventricules du cœur , Arch. gén. de méd. 145:25, 1880. 16. Widerøe, Sofus: Die Massenverhältnisse des Herzens unter pathologischen Zuständen , Christiania, Jacob Dybwad, 1911. 17. Starling, E. H.: Principles of Human Physiology , ed. 6, revised by C. L. Evans, Philadelphia, Lea & Febiger, 1933, p. 773. 18. Patterson, S. W., and Starling, E. H.: On the Mechanical Factors Which Determine the Output of the Ventricles , J. Physiol. 48:357 ( (Sept. 8) ) 1914. 19. Gesell, Robert A.: Cardiodynamics in Heart Block as Affected by Auricular Systole, Auricular Fibrillation and Stimulation of the Vagus Nerve , Am. J. Physiol. 40:267 ( (April 1) ) 1916. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EXPERIMENTAL CONCENTRIC AND ECCENTRIC CARDIAC HYPERTROPHY IN RATS

Archives of Internal Medicine , Volume 56 (3) – Sep 1, 1935

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1935.00170010099005
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Abstract

Abstract Chanutin (with Ferris1 and with Barksdale2) has recently shown that in rats deprived of 80 per cent of their renal tissue progressive renal lesions, arterial hypertension and cardiac hypertrophy develop. The width of the myocardial fibers of the right ventricle does not change, while the diameter of the fibers of the left ventricle bears "a substantial relationship" to the ratio of the weight of the heart to the surface area. The comparison of a unidimensional or bidimensional method of measurement with a volumetric method has in the past led to serious misinterpretation of data. In this instance there has been no error in conclusions, but the comparison of width of the fibers (a linear measurement) with the weight of the heart (proportional to the total volume of all the fibers) has concealed an important fact, namely, that when the fibers of the heart of the rat hypertrophy References 1. Chanutin, A., and Ferris, E. B.: Experimental Renal Insufficiency Produced by Partial Nephrectomy: I. Control Diet , Arch. Int. Med. 49:767 ( (May) ) 1932.Crossref 2. Chanutin, A., and Barksdale, E. E.: Experimental Renal Insufficiency Produced by Partial Nephrectomy: II. Relationship of Left Ventricular Hypertrophy, the Width of the Cardiac Muscle Fiber and Hypertension in the Rat , Arch. Int. Med. 52:739 ( (Nov.) ) 1933.Crossref 3. MacKay, L. L., and MacKay, E. M.: Factors Which Determine Renal Weight: I. Methods , Am. J. Physiol. 83:179 ( (Dec.) ) 1927. 4. Herrmann, G. R.: Experimental Heart Disease: I. Methods of Dividing Hearts, with Sectional and Proportional Weights and Ratios for Two Hundred Normal Dogs' Hearts , Am. Heart J. 1:213 ( (Dec.) ) 1925.Crossref 5. Krehl, L.: The Principles of Clinical Pathology , translated by A. W. Hewlett, ed. 2, Philadelphia, J. B. Lippincott Company, 1907, p. 60. 6. Fishberg, A. M.: Hypertension and Nephritis , ed. 2, Philadelphia, Lea & Febiger, 1931, p. 170. 7. Adami, J. G.: Notes upon Cardiac Hypertrophy , Montreal M. J. 23:811 ( (May) ) 1895. 8. Kaufmann, E.: Pathology for Students and Practitioners , translated by S. P. Reimann, Philadelphia, P. Blakiston's Son & Co., 1929, vol. 1, p. 73. 9. Mönckeberg, J. G.: Die Erkrankungen des Myokards und des spezifischen Muskelsystems , in Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1924, vol. 2, p. 350. 10. Dietlen, Hans: Herzgrösse, Herzmessmethoden 11. Anpassung, Hypertrophie. Dilatation, Tonus des Herzens, in Bethe, A. 12. Bergmann, G. 13. Embden, G., and Ellinger, A.: Handbuch der normalen und pathologischen Physiologic , Berlin. Julius Springer, 1926, vol. 7, p. 351. 14. Hales, Stephen: Statical Essays , London, W. Innys and others, 1733. 15. du Castel: Recherches sur l'hypertrophie et la dilatation des ventricules du cœur , Arch. gén. de méd. 145:25, 1880. 16. Widerøe, Sofus: Die Massenverhältnisse des Herzens unter pathologischen Zuständen , Christiania, Jacob Dybwad, 1911. 17. Starling, E. H.: Principles of Human Physiology , ed. 6, revised by C. L. Evans, Philadelphia, Lea & Febiger, 1933, p. 773. 18. Patterson, S. W., and Starling, E. H.: On the Mechanical Factors Which Determine the Output of the Ventricles , J. Physiol. 48:357 ( (Sept. 8) ) 1914. 19. Gesell, Robert A.: Cardiodynamics in Heart Block as Affected by Auricular Systole, Auricular Fibrillation and Stimulation of the Vagus Nerve , Am. J. Physiol. 40:267 ( (April 1) ) 1916.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1935

References

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