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EXPERIMENTAL CHRONIC DUODENAL OBSTRUCTION: CHANGES IN THE BLOOD AND OTHER PATHOLOGIC CHANGES

EXPERIMENTAL CHRONIC DUODENAL OBSTRUCTION: CHANGES IN THE BLOOD AND OTHER PATHOLOGIC CHANGES Abstract Our primary object in the experimental production of chronic stenosis of the duodenum was to determine whether there was any relationship between intestinal stasis and alterations in the blood. Clinically, Löwenberg1 and Olivet2 found an increase in the bacterial content of the duodenum in cases of pernicious anemia. Experimentally, Seyderhelm3 claimed to have produced a pernicious anemialike picture in dogs with chronic obstructions of the small intestine. Brown and his co-workers4 reported the occurrence of "toxic nephritis" in a series of cases of chronic duodenal obstruction. Functional studies of the kidneys indicated renal insufficiency. Chemical examination of the blood revealed an increase in the urea nitrogen and creatinine, a high carbon dioxide carrying capacity and a low chloride content. In previous papers,5 a new technic for producing chronic stenosis of the duodenum was described. The duodenum was chosen as the site of the obstruction because, References 1. Löwenberg, W.: Pathologische Bacterienansiedlung im Duodenum und ihre ursächlichen Faktoren , Klin. Wchnschr. 5:548 ( (March 26) ) 1926.Crossref 2. Olivet, J.: Bakteriologie des Duodenums , Klin. Wchnschr. 5:307 ( (Feb. 19) ) 1926.Crossref 3. Seyderhelm, R.: Die Bedeutung des Dünndarms für die Genese der perniziösen Anämie , Klin. Wchnschr. 3:568 ( (April 1) ) 1924.Crossref 4. Seyderhelm, R.; Lehman, W., and Wichels, P.: Experimentelle Intestinale perniziöse Anämie beim Hund , Klin. Wchnschr. 3:1439 ( (Aug. 5) ) 1924.Crossref 5. Brown, G. E.; Eusterman, G. B.; Hartman, H. R., and Rowntree, L. G.: Toxic Nephritis in Pyloric and Duodenal Obstruction , Arch. Int. Med. 32:425 ( (Sept.) ) 1923.Crossref 6. Berg, B. N.; Meleney, F. L., and Jobling, J. W.: Experimental Chronic Duodenal Obstruction , Arch. Surg. 14:752 ( (March) ) 1927.Crossref 7. Meleney, F. L.; Berg, B. N., and Jobling, J. W.: Experimental Chronic Duodenal Obstruction , Arch. Surg. 14:762 ( (March) ) 1927.Crossref 8. McKinley, E. B.: To be published. 9. Nothnagel, H.: Diseases of the Intestines and Peritoneum , Philadelphia, W. B. Saunders Company, 1907, p. 355. 10. Herczel, E.: Experimentelle und histologische Untersuchungen über compensatorische Muskelhypertrophie bei Darmstenosen , Ztschr. f. klin. Med. 11:321, 1886. 11. Patel, M.: Remarques sur l'état du segment intestinal situé en amont d'une sténose , Lyon méd. 93:73, 1900. 12. MacNider, W. de B.: A Pathological Study of the Acquired Chronic Nephropathy of the Dog , J. M. Research 34:177 ( (May) ) 1916. 13. Berg, B. N.; Zau, Z. D., and Jobling, J. W.: Bactericidal Function of the Liver , Proc. Soc. Exper. Biol. & Med. 24:433, 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

EXPERIMENTAL CHRONIC DUODENAL OBSTRUCTION: CHANGES IN THE BLOOD AND OTHER PATHOLOGIC CHANGES

Archives of Surgery , Volume 16 (2) – Feb 1, 1928

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Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1928.01140020144008
Publisher site
See Article on Publisher Site

Abstract

Abstract Our primary object in the experimental production of chronic stenosis of the duodenum was to determine whether there was any relationship between intestinal stasis and alterations in the blood. Clinically, Löwenberg1 and Olivet2 found an increase in the bacterial content of the duodenum in cases of pernicious anemia. Experimentally, Seyderhelm3 claimed to have produced a pernicious anemialike picture in dogs with chronic obstructions of the small intestine. Brown and his co-workers4 reported the occurrence of "toxic nephritis" in a series of cases of chronic duodenal obstruction. Functional studies of the kidneys indicated renal insufficiency. Chemical examination of the blood revealed an increase in the urea nitrogen and creatinine, a high carbon dioxide carrying capacity and a low chloride content. In previous papers,5 a new technic for producing chronic stenosis of the duodenum was described. The duodenum was chosen as the site of the obstruction because, References 1. Löwenberg, W.: Pathologische Bacterienansiedlung im Duodenum und ihre ursächlichen Faktoren , Klin. Wchnschr. 5:548 ( (March 26) ) 1926.Crossref 2. Olivet, J.: Bakteriologie des Duodenums , Klin. Wchnschr. 5:307 ( (Feb. 19) ) 1926.Crossref 3. Seyderhelm, R.: Die Bedeutung des Dünndarms für die Genese der perniziösen Anämie , Klin. Wchnschr. 3:568 ( (April 1) ) 1924.Crossref 4. Seyderhelm, R.; Lehman, W., and Wichels, P.: Experimentelle Intestinale perniziöse Anämie beim Hund , Klin. Wchnschr. 3:1439 ( (Aug. 5) ) 1924.Crossref 5. Brown, G. E.; Eusterman, G. B.; Hartman, H. R., and Rowntree, L. G.: Toxic Nephritis in Pyloric and Duodenal Obstruction , Arch. Int. Med. 32:425 ( (Sept.) ) 1923.Crossref 6. Berg, B. N.; Meleney, F. L., and Jobling, J. W.: Experimental Chronic Duodenal Obstruction , Arch. Surg. 14:752 ( (March) ) 1927.Crossref 7. Meleney, F. L.; Berg, B. N., and Jobling, J. W.: Experimental Chronic Duodenal Obstruction , Arch. Surg. 14:762 ( (March) ) 1927.Crossref 8. McKinley, E. B.: To be published. 9. Nothnagel, H.: Diseases of the Intestines and Peritoneum , Philadelphia, W. B. Saunders Company, 1907, p. 355. 10. Herczel, E.: Experimentelle und histologische Untersuchungen über compensatorische Muskelhypertrophie bei Darmstenosen , Ztschr. f. klin. Med. 11:321, 1886. 11. Patel, M.: Remarques sur l'état du segment intestinal situé en amont d'une sténose , Lyon méd. 93:73, 1900. 12. MacNider, W. de B.: A Pathological Study of the Acquired Chronic Nephropathy of the Dog , J. M. Research 34:177 ( (May) ) 1916. 13. Berg, B. N.; Zau, Z. D., and Jobling, J. W.: Bactericidal Function of the Liver , Proc. Soc. Exper. Biol. & Med. 24:433, 1927.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1928

References