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EXPERIMENTAL CHRONIC CUTANEOUS BLASTOMYCOSIS IN MONKEYS: A STUDY OF THE ETIOLOGIC AGENT

EXPERIMENTAL CHRONIC CUTANEOUS BLASTOMYCOSIS IN MONKEYS: A STUDY OF THE ETIOLOGIC AGENT Abstract The clinical term blastomycosis has been used to designate any disease caused by a yeastlike fungus. At the present time, however, there is a growing tendency to limit this term to those diseases in which the causative fungi occur in the lesions, without associated mycelium, as large, round to oval cells possessing well defined membranes, well marked double contours and granular cytoplasm and multiplying in the tissues by budding, though capable of producing hyphae in more or less abundance in cultures. In line with this conception it is customary to designate those diseases caused by other yeastlike fungi by more specific terms, such as coccidioidal granuloma, sporotrichosis, torulosis and cytomycosis. It is now evident that the term blastomycosis is doubly a misnomer. It was applied under the mistaken impression (1) that the causative organism is a true yeast and (2) that Blastomyces instead of Saccharomyces is the correct scientific name References 1. Ota, M., and Kawatsure, S.: Zur Aetiologie der echten und falschen Blastomycosen, besonders der Gilchristschen Krankheit , Arch. f. Dermat. u. Syph. 169: 173, 1933.Crossref 2. Gilchrist, T. C.: A Case of Blastomycetic Dermatitis in Man , Johns Hopkins Hosp. Rep. 1:269, 1896. 3. Gilchrist, T. C., and Stokes, W. R.: A Case of Pseudo-Lupus Vulgaris Caused by a Blastomyces , J. Exper. Med. 3:53, 1898.Crossref 4. Castellani, A., and Jacono, I.: Observations on Fungi Isolated from Cases of Blastomycosis Cutis and Blastomycosis Pulmonalis in North America and Europe: Remarks on Blastomycetin , J. Trop. Med. 36:297 ( (Oct. 16) ) 1933. 5. Agostini, A.: Observations on Fungi Found in Cases of North American Blastomycosis of the Skin and Lungs , J. Trop. Med. 35:266 ( (Sept. 1) ) 1932. 6. Rewbridge, A. G.: Dodge, C. W., and Ayers, T. T.: A Case of Meningitis Due to Endomyces Capsulatus (New Species) , Am. J. Path. 5:349 ( (July) ) 1929. 7. MacBryde, C. M., and Thompson, E. J.: Meningitis and Dermatitis Caused by a New Variety of Blastomycete (Endomycete) , Arch. Dermat. & Syph. 27:49 ( (Jan.) ) 1933. 8. Moore, M.: Blastomycosis: Report of a Case, with a Study of an Etiologic Factor and a Classification of the Organism , Ann. Missouri Bot. Gard. 20:79 ( (Feb.) ) 1932. 9. Thaxter, R., quoted by Medlar, E. M.: A Cutaneous Infection Caused by a New Fungus, Phialophora Verrucosa, with a Study of the Fungus , J. M. Research 32:507, 1915. 10. Ricketts, H. T.: Oidiomycosis (Blastomycosis) of the Skin and Its Fungi , J. M. Research 1:373 ( (Dec.) ) 1901. 11. Hektoen, L.: Systemic Blastomycosis and Coccidioidal Granuloma , J. A. M. A. 49:1071 ( (Sept. 28) ) 1907. 12. Montgomery, F. H., and Ormsby, O. S.: Systemic Blastomycosis: Its Etiologic, Pathologic and Clinical Features as Established by a Critical Survey and Summary of Twenty-Two Cases, Seven Previously Unpublished. The Relation of Blastomycosis to Coccidioidal Granuloma , Arch. Int. Med. 2:1 ( (Aug.) ) 1908. 13. Wade, H. W., and Bel, G. S.: A Critical Consideration of Systemic Blastomycosis , Arch. Int. Med. 18:103 ( (July) ) 1916. 14. Benham, R. W.: The Fungi of Blastomycosis and Coccidioidal Granuloma , Arch. Dermat. & Syph. 30:385 [ (Sept.) ] 1934 15. DeMonbreun, W. A.: The Cultivation and Cultural Characteristics of Darling's Histoplasma Capsulatum , Am. J. Trop. Med. 14:93 ( (March) ) 1934. 16. Norton, J. F.; Thomas, J. G., and Broom, Norma H.: Laboratory Tests for Tubercle Bacilli by Culture Methods , Am. Rev. Tuberc. 25:378 ( (March) ) 1932. 17. The formula for Schaudinn's fluid is: Saturated mercuric chloride in physiologic solution of sodium chloride, 65 cc.; alcohol, 95 per cent, 33 cc., and glacial acetic acid, 2 cc. 18. Wade, H. W.: A Variation of Gemmation of Blastomyces Dermatitidis in the Tissue Lesion , J. Infect. Dis. 18:618, 1916. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EXPERIMENTAL CHRONIC CUTANEOUS BLASTOMYCOSIS IN MONKEYS: A STUDY OF THE ETIOLOGIC AGENT

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1935.01460240056006
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Abstract

Abstract The clinical term blastomycosis has been used to designate any disease caused by a yeastlike fungus. At the present time, however, there is a growing tendency to limit this term to those diseases in which the causative fungi occur in the lesions, without associated mycelium, as large, round to oval cells possessing well defined membranes, well marked double contours and granular cytoplasm and multiplying in the tissues by budding, though capable of producing hyphae in more or less abundance in cultures. In line with this conception it is customary to designate those diseases caused by other yeastlike fungi by more specific terms, such as coccidioidal granuloma, sporotrichosis, torulosis and cytomycosis. It is now evident that the term blastomycosis is doubly a misnomer. It was applied under the mistaken impression (1) that the causative organism is a true yeast and (2) that Blastomyces instead of Saccharomyces is the correct scientific name References 1. Ota, M., and Kawatsure, S.: Zur Aetiologie der echten und falschen Blastomycosen, besonders der Gilchristschen Krankheit , Arch. f. Dermat. u. Syph. 169: 173, 1933.Crossref 2. Gilchrist, T. C.: A Case of Blastomycetic Dermatitis in Man , Johns Hopkins Hosp. Rep. 1:269, 1896. 3. Gilchrist, T. C., and Stokes, W. R.: A Case of Pseudo-Lupus Vulgaris Caused by a Blastomyces , J. Exper. Med. 3:53, 1898.Crossref 4. Castellani, A., and Jacono, I.: Observations on Fungi Isolated from Cases of Blastomycosis Cutis and Blastomycosis Pulmonalis in North America and Europe: Remarks on Blastomycetin , J. Trop. Med. 36:297 ( (Oct. 16) ) 1933. 5. Agostini, A.: Observations on Fungi Found in Cases of North American Blastomycosis of the Skin and Lungs , J. Trop. Med. 35:266 ( (Sept. 1) ) 1932. 6. Rewbridge, A. G.: Dodge, C. W., and Ayers, T. T.: A Case of Meningitis Due to Endomyces Capsulatus (New Species) , Am. J. Path. 5:349 ( (July) ) 1929. 7. MacBryde, C. M., and Thompson, E. J.: Meningitis and Dermatitis Caused by a New Variety of Blastomycete (Endomycete) , Arch. Dermat. & Syph. 27:49 ( (Jan.) ) 1933. 8. Moore, M.: Blastomycosis: Report of a Case, with a Study of an Etiologic Factor and a Classification of the Organism , Ann. Missouri Bot. Gard. 20:79 ( (Feb.) ) 1932. 9. Thaxter, R., quoted by Medlar, E. M.: A Cutaneous Infection Caused by a New Fungus, Phialophora Verrucosa, with a Study of the Fungus , J. M. Research 32:507, 1915. 10. Ricketts, H. T.: Oidiomycosis (Blastomycosis) of the Skin and Its Fungi , J. M. Research 1:373 ( (Dec.) ) 1901. 11. Hektoen, L.: Systemic Blastomycosis and Coccidioidal Granuloma , J. A. M. A. 49:1071 ( (Sept. 28) ) 1907. 12. Montgomery, F. H., and Ormsby, O. S.: Systemic Blastomycosis: Its Etiologic, Pathologic and Clinical Features as Established by a Critical Survey and Summary of Twenty-Two Cases, Seven Previously Unpublished. The Relation of Blastomycosis to Coccidioidal Granuloma , Arch. Int. Med. 2:1 ( (Aug.) ) 1908. 13. Wade, H. W., and Bel, G. S.: A Critical Consideration of Systemic Blastomycosis , Arch. Int. Med. 18:103 ( (July) ) 1916. 14. Benham, R. W.: The Fungi of Blastomycosis and Coccidioidal Granuloma , Arch. Dermat. & Syph. 30:385 [ (Sept.) ] 1934 15. DeMonbreun, W. A.: The Cultivation and Cultural Characteristics of Darling's Histoplasma Capsulatum , Am. J. Trop. Med. 14:93 ( (March) ) 1934. 16. Norton, J. F.; Thomas, J. G., and Broom, Norma H.: Laboratory Tests for Tubercle Bacilli by Culture Methods , Am. Rev. Tuberc. 25:378 ( (March) ) 1932. 17. The formula for Schaudinn's fluid is: Saturated mercuric chloride in physiologic solution of sodium chloride, 65 cc.; alcohol, 95 per cent, 33 cc., and glacial acetic acid, 2 cc. 18. Wade, H. W.: A Variation of Gemmation of Blastomyces Dermatitidis in the Tissue Lesion , J. Infect. Dis. 18:618, 1916.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jun 1, 1935

References