Abstract • The ocular changes following the introduction of a copper foreign body in the eye of rabbits were studied by histological, histochemical, and quantitative analysis. The findings are compared with previously reported changes observed in vivo. The efficacy of ophthalmoscopy and electroretinography in the early detection of chalcosis is compared with the efficacy of a new method, diagnostic X-ray spectrometry. References 1. Duke-Elder S, MacFaul PA: Injuries: Mechanical injuries , in Duke-Elder S (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1972, vol 14, pp 512-525. 2. Knave B: Electroretinography in eyes with retained intraocular foreign bodies: A clinical study . Acta Ophthalmol , (suppl 100) , 1969, pp 1-63. 3. Schmidt JGHS, Stute A: Electroretinogram and ophthalmoscopic findings in intra-vitreous iron, copper and lead particles . Proceedings, 10th ISCERG Symposium , Los Angeles, 1972, W Junk Publishers, pp 85-90. 4. Rao NA, Tso MOM, Rosenthal AR: Chalcosis in the human eye . Arch Ophthalmol 94:1379-1384, 1976.Crossref 5. Yassur Y, Zauberman H, Zidon M: Identification of copper ions in aqueous and vitreous of eyes containing copper and iron foreign bodies . Br J Ophthalmol 59:590-592, 1975.Crossref 6. Rosenthal AR, Hopkins JL, Appleton B et al: Studies on intraocular copper foreign bodies: Atomic absorption spectrometry . Arch Ophthalmol 92:431-436, 1974.Crossref 7. Zeimer R, Weinreb A, Loewinger E, et al: Detection and analysis of metals in the eye by x-ray spectrometry . Med Phys 1:251-256, 1974.Crossref 8. Belkin M, Loewinger E, Weinreb A, et al: A non-invasive method for the detection and analysis of metals in the eye . Invest Ophthalmol 15:770-773, 1976. 9. Gorodetsky R, Weinreb A, Zeimer R, et al: Non-invasive copper measurement in chalcosis: Comparison with electroretinography and ophthalmoscopy . Arch Ophthalmol 95:1059-1064, 1977.Crossref 10. Bertin EP: Principles and Practice of X-ray Spectrometric Analysis . New York, Plenum Press, 1970, pp 379-421. 11. Borchard U, Schneider KU: Intoxication, detoxication and copper storage of central nervous tissue at different external Cu (II) concentrations . Arch Toxicol 33:17-30, 1974. 12. Uzman LL, Jakus MA: The Kayser-Fleischer ring: A histochemical and electron microscope study . Neurology 7:341-355, 1957.Crossref 13. Del Castillo-Nicolau J, Hufschmidt HJ: Reversible poisoning of nerve fibres by heavy metal ions . Nature 167:146-147, 1951.Crossref 14. Delaney WV: Presumed ocular chalcosis: A reversible maculopathy . Ann Ophthalmol 7:378-380, 1975. 15. Cordes FC, Harrington DO: Bilateral absorption of intraocular copper with chalcosis in one eye: Report of a case . Am J Ophthalmol 18:348-352, 1935. 16. Beckerman BL: Intraocular foreign body extraction in early chalcosis . Arch Ophthalmol 87:444-446, 1972.Crossref 17. Kjerrumgaard E: A case of ocular chalcosis . Acta Ophthalmol 19:261-266, 1941.Crossref 18. Oster GK: Clinical reaction of the copper intrauterine device . Fertil Steril 23:18-23, 1972.
Archives of Ophthalmology – American Medical Association
Published: Jan 1, 1978
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