Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

EXPERIMENTAL ARSPHENAMINE DERMATITIS: OBSERVATIONS ON ITS ALLERGIC NATURE, WITH SPECIAL ATTENTION TO THE SCHULTZ-DALE PHENOMENON

EXPERIMENTAL ARSPHENAMINE DERMATITIS: OBSERVATIONS ON ITS ALLERGIC NATURE, WITH SPECIAL ATTENTION... Abstract This is the fourth of a series of studies on the nature of cutaneous idiosyncrasy to arsphenamine, as produced in guinea-pigs. In preliminary experiments,1 made with both intradermal and intravenous injections, it seemed that a locally irritating effect following the second injection was a prerequisite, if a cutaneous flare was to result from a subsequent intravenous injection of neoarsphenamine. In a more recent, unpublished work this conclusion has been found to be false. Carefully controlled experiments on a series of twelve guinea-pigs demonstrated that true sensitivity had developed after but one intradermal injection, since a typical cutaneous flare resulted from a subsequent intravenous injection. The explanation of this variation in results was not immediately apparent. Attention was later called2 to the fact that a diet low in vitamin C apparently increased cutaneous susceptibility to arsphenamine in the guinea-pig, while a diet high in vitamin C seemed to inhibit References 1. Cormia, F. E. Experimental Arsphenamine Dermatitis , Canad. M. A. J. 34:272 ( (March) ) 1936. 2. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Vitamin C in the Production of Arsphenamine Sensitiveness , Canad. M. A. J. 36:392 ( (April) ) 1937. 3. Cormia, F. E.: Experimental Arsphenamine Dermatitis: Reaction to Arsphenamine in Normal Guinea-Pigs and in Guinea-Pigs Given Staphylococcus Toxin , Arch. Dermat. & Syph. 34:107 ( (July) ) 1936. 4. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Infection on the Production of Arsphenamine Sensitiveness in the Guinea-Pig, to be published. 5. Cannon, A., and Karelitz, M.: Intradermal Tests in Relation to Arsphenamine Dermatitis: A Study Based on Two Hundred and Fifty-Six Clinical Cases , Arch. Dermat. & Syph. 29:485 ( (April) ) 1934. 6. Moore, J. E.; Woo, S.; Robinson, H., and Gay, S.: Reactions of the Skin Following the Intradermal Injection of Arsphenamine: Post-Arsphenamine Dermatitis , Arch. Dermat. & Syph. 23:74 ( (Jan.) ) 1931. 7. Schoch, A.: Arsphenamine Dermatitis: Attempted Sensitization to Neoarsphenamine and Further Observations on the Patch Test , Arch. Dermat. & Syph. 30:672 ( (Nov.) ) 1934. 8. Nathan, E.; Munk, A., and Grundmann, H.: Ueber experimentelle Sensibilisierungs- und Allergieerscheinungen der Haut gegenüber Myosalvarsan , Klin. Wchnschr. 8:1714 ( (Sept. 10) ) 1929. 9. Schreiner, K., and Ensbruner, G.: Weitere Beiträge zur Frage der allergischen Salvarsanhauterscheinungen , Arch. f. Dermat. u. Syph. 170:61, 1934. 10. Birnbaum, G.: Neuere Untersuchungen über die Salvarsanschädigungen der Haut (Kritischer Ergebnisbericht) , Zentralbl. f. Haut- u. Geschlechtskr. 49:97, 1934. 11. Jadassohn, W., and Schaaf, F.: Untersuchungen über den Mechanismus der anaphylakitsch-urtikariellen Reaktion (Schultz-Dalesche Versuche mit Haptenen) , Arch. f. Dermat. u. Syph. 170:33, 1934. 12. Kallós, P., and Kallós-Deffner, L.: Experimentelle Untersuchungen über Salvarsanallergie , Klin. Wchnschr. 14:1074 ( (July 27) ) 1935. 13. Dale, H. H.: The Anaphylactic Reaction of Plain Muscle in the Guinea-Pig , J. Pharmacol. & Exper. Therap. 13:167, 1912. 14. Schultz, W. H.: Physiological Studies in Anaphylaxis: I. The Reaction of Smooth Muscle of the Guinea Pig Sensitized with Horse Serum , J. Pharmacol. & Exper. Therap. 1:549, 1909-1910. 15. Sulzberger, M.: Hypersensitiveness to Arsphenamine in Guinea-Pigs: I. Experiments in Prevention and in Desensitization , Arch. Dermat. & Syph. 20:669 ( (Nov.) ) 1929. 16. Only the interpretation of the graphs will be given, since the original tracings were lost and cannot be replaced. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

EXPERIMENTAL ARSPHENAMINE DERMATITIS: OBSERVATIONS ON ITS ALLERGIC NATURE, WITH SPECIAL ATTENTION TO THE SCHULTZ-DALE PHENOMENON

Loading next page...
 
/lp/american-medical-association/experimental-arsphenamine-dermatitis-observations-on-its-allergic-CYmAk9UgaL
Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1937.01480050036004
Publisher site
See Article on Publisher Site

Abstract

Abstract This is the fourth of a series of studies on the nature of cutaneous idiosyncrasy to arsphenamine, as produced in guinea-pigs. In preliminary experiments,1 made with both intradermal and intravenous injections, it seemed that a locally irritating effect following the second injection was a prerequisite, if a cutaneous flare was to result from a subsequent intravenous injection of neoarsphenamine. In a more recent, unpublished work this conclusion has been found to be false. Carefully controlled experiments on a series of twelve guinea-pigs demonstrated that true sensitivity had developed after but one intradermal injection, since a typical cutaneous flare resulted from a subsequent intravenous injection. The explanation of this variation in results was not immediately apparent. Attention was later called2 to the fact that a diet low in vitamin C apparently increased cutaneous susceptibility to arsphenamine in the guinea-pig, while a diet high in vitamin C seemed to inhibit References 1. Cormia, F. E. Experimental Arsphenamine Dermatitis , Canad. M. A. J. 34:272 ( (March) ) 1936. 2. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Vitamin C in the Production of Arsphenamine Sensitiveness , Canad. M. A. J. 36:392 ( (April) ) 1937. 3. Cormia, F. E.: Experimental Arsphenamine Dermatitis: Reaction to Arsphenamine in Normal Guinea-Pigs and in Guinea-Pigs Given Staphylococcus Toxin , Arch. Dermat. & Syph. 34:107 ( (July) ) 1936. 4. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Infection on the Production of Arsphenamine Sensitiveness in the Guinea-Pig, to be published. 5. Cannon, A., and Karelitz, M.: Intradermal Tests in Relation to Arsphenamine Dermatitis: A Study Based on Two Hundred and Fifty-Six Clinical Cases , Arch. Dermat. & Syph. 29:485 ( (April) ) 1934. 6. Moore, J. E.; Woo, S.; Robinson, H., and Gay, S.: Reactions of the Skin Following the Intradermal Injection of Arsphenamine: Post-Arsphenamine Dermatitis , Arch. Dermat. & Syph. 23:74 ( (Jan.) ) 1931. 7. Schoch, A.: Arsphenamine Dermatitis: Attempted Sensitization to Neoarsphenamine and Further Observations on the Patch Test , Arch. Dermat. & Syph. 30:672 ( (Nov.) ) 1934. 8. Nathan, E.; Munk, A., and Grundmann, H.: Ueber experimentelle Sensibilisierungs- und Allergieerscheinungen der Haut gegenüber Myosalvarsan , Klin. Wchnschr. 8:1714 ( (Sept. 10) ) 1929. 9. Schreiner, K., and Ensbruner, G.: Weitere Beiträge zur Frage der allergischen Salvarsanhauterscheinungen , Arch. f. Dermat. u. Syph. 170:61, 1934. 10. Birnbaum, G.: Neuere Untersuchungen über die Salvarsanschädigungen der Haut (Kritischer Ergebnisbericht) , Zentralbl. f. Haut- u. Geschlechtskr. 49:97, 1934. 11. Jadassohn, W., and Schaaf, F.: Untersuchungen über den Mechanismus der anaphylakitsch-urtikariellen Reaktion (Schultz-Dalesche Versuche mit Haptenen) , Arch. f. Dermat. u. Syph. 170:33, 1934. 12. Kallós, P., and Kallós-Deffner, L.: Experimentelle Untersuchungen über Salvarsanallergie , Klin. Wchnschr. 14:1074 ( (July 27) ) 1935. 13. Dale, H. H.: The Anaphylactic Reaction of Plain Muscle in the Guinea-Pig , J. Pharmacol. & Exper. Therap. 13:167, 1912. 14. Schultz, W. H.: Physiological Studies in Anaphylaxis: I. The Reaction of Smooth Muscle of the Guinea Pig Sensitized with Horse Serum , J. Pharmacol. & Exper. Therap. 1:549, 1909-1910. 15. Sulzberger, M.: Hypersensitiveness to Arsphenamine in Guinea-Pigs: I. Experiments in Prevention and in Desensitization , Arch. Dermat. & Syph. 20:669 ( (Nov.) ) 1929. 16. Only the interpretation of the graphs will be given, since the original tracings were lost and cannot be replaced.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Nov 1, 1937

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month