Abstract This is the fourth of a series of studies on the nature of cutaneous idiosyncrasy to arsphenamine, as produced in guinea-pigs. In preliminary experiments,1 made with both intradermal and intravenous injections, it seemed that a locally irritating effect following the second injection was a prerequisite, if a cutaneous flare was to result from a subsequent intravenous injection of neoarsphenamine. In a more recent, unpublished work this conclusion has been found to be false. Carefully controlled experiments on a series of twelve guinea-pigs demonstrated that true sensitivity had developed after but one intradermal injection, since a typical cutaneous flare resulted from a subsequent intravenous injection. The explanation of this variation in results was not immediately apparent. Attention was later called2 to the fact that a diet low in vitamin C apparently increased cutaneous susceptibility to arsphenamine in the guinea-pig, while a diet high in vitamin C seemed to inhibit References 1. Cormia, F. E. Experimental Arsphenamine Dermatitis , Canad. M. A. J. 34:272 ( (March) ) 1936. 2. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Vitamin C in the Production of Arsphenamine Sensitiveness , Canad. M. A. J. 36:392 ( (April) ) 1937. 3. Cormia, F. E.: Experimental Arsphenamine Dermatitis: Reaction to Arsphenamine in Normal Guinea-Pigs and in Guinea-Pigs Given Staphylococcus Toxin , Arch. Dermat. & Syph. 34:107 ( (July) ) 1936. 4. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Infection on the Production of Arsphenamine Sensitiveness in the Guinea-Pig, to be published. 5. Cannon, A., and Karelitz, M.: Intradermal Tests in Relation to Arsphenamine Dermatitis: A Study Based on Two Hundred and Fifty-Six Clinical Cases , Arch. Dermat. & Syph. 29:485 ( (April) ) 1934. 6. Moore, J. E.; Woo, S.; Robinson, H., and Gay, S.: Reactions of the Skin Following the Intradermal Injection of Arsphenamine: Post-Arsphenamine Dermatitis , Arch. Dermat. & Syph. 23:74 ( (Jan.) ) 1931. 7. Schoch, A.: Arsphenamine Dermatitis: Attempted Sensitization to Neoarsphenamine and Further Observations on the Patch Test , Arch. Dermat. & Syph. 30:672 ( (Nov.) ) 1934. 8. Nathan, E.; Munk, A., and Grundmann, H.: Ueber experimentelle Sensibilisierungs- und Allergieerscheinungen der Haut gegenüber Myosalvarsan , Klin. Wchnschr. 8:1714 ( (Sept. 10) ) 1929. 9. Schreiner, K., and Ensbruner, G.: Weitere Beiträge zur Frage der allergischen Salvarsanhauterscheinungen , Arch. f. Dermat. u. Syph. 170:61, 1934. 10. Birnbaum, G.: Neuere Untersuchungen über die Salvarsanschädigungen der Haut (Kritischer Ergebnisbericht) , Zentralbl. f. Haut- u. Geschlechtskr. 49:97, 1934. 11. Jadassohn, W., and Schaaf, F.: Untersuchungen über den Mechanismus der anaphylakitsch-urtikariellen Reaktion (Schultz-Dalesche Versuche mit Haptenen) , Arch. f. Dermat. u. Syph. 170:33, 1934. 12. Kallós, P., and Kallós-Deffner, L.: Experimentelle Untersuchungen über Salvarsanallergie , Klin. Wchnschr. 14:1074 ( (July 27) ) 1935. 13. Dale, H. H.: The Anaphylactic Reaction of Plain Muscle in the Guinea-Pig , J. Pharmacol. & Exper. Therap. 13:167, 1912. 14. Schultz, W. H.: Physiological Studies in Anaphylaxis: I. The Reaction of Smooth Muscle of the Guinea Pig Sensitized with Horse Serum , J. Pharmacol. & Exper. Therap. 1:549, 1909-1910. 15. Sulzberger, M.: Hypersensitiveness to Arsphenamine in Guinea-Pigs: I. Experiments in Prevention and in Desensitization , Arch. Dermat. & Syph. 20:669 ( (Nov.) ) 1929. 16. Only the interpretation of the graphs will be given, since the original tracings were lost and cannot be replaced.
Archives of Dermatology and Syphilology – American Medical Association
Published: Nov 1, 1937
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